Efficient hardware prototype of ECDSA modules for blockchain applications

This paper concentrates on the hardware implementation of efficient and re- configurable elliptic curve digital signature algorithm (ECDSA) that is suitable for verifying transactions in Blockchain related applications. Despite ECDSA architecture being computationally expensive, the usage of a dedicated stand-alone circuit enables speedy execution of arithmetic operations. The prototype put forth supports N-bit elliptic curve cryptography (ECC) group operations, signature generation and verification over a prime field for any elliptic curve. The research proposes new hardware framework for modular multiplication and modular multiplicative inverse which is adopted for group operations involved in ECDSA. Every hardware design offered are simulated using modelsim register transfer logic (RTL) simulator. Field programmable gate array (FPGA) implementation of var- ious modules within ECDSA circuit is compared with equivalent existing techniques that is both hardware and software based to highlight the superiority of the suggested work. The results showcased prove that the designs implemented are both area and speed efficient with faster execution and less resource utilization while maintaining the same level of security. The suggested ECDSA structure could replace the software equivalent of digital signatures in hardware blockchain to thwart software attacks and to provide better data protection

INFLUENCE OF PHARMACEUTICAL CARE ACTIVITIES ON KNOWLEDGE ATTITUDE AND PRACTICE (KAP) AMONG DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL

Objective: To assess the influence of pharmaceutical care activities on Knowledge, Attitude and Practice (KAP) among type 2 diabetic patients. Methods: A total of about 301 patients with type 2 Diabetes Mellitus were recruited from a tertiary care hospital. Patients were educated about their disease condition, lifestyle modifications and diet regimen to be followed and were given instructions for improving medication adherence. In the initial session, no pharmaceutical care was given, in the second session patient counseling was given verbally and in the last session patient counseling was given both verbally and non-verbally by means of pamphlet distribution. KAP questionnaire and glycemic levels (glycated hemoglobin, fasting blood sugar and post-prandial blood sugar) of participants were obtained at baseline and at follow up. Results: The baseline values of FBS in patients before intervention was found to be 176.5±74.46 mg/dL and it was reduced to 140.7±43.9 mg/dL after 3 mo. Henceforth, there was also an improvement in the PPBS values which was found to be 254±77.3 mg/dL at the baseline and was 212.9±54.2 mg/dL after intervention. The baseline values of HbA1c is 8.144±1.727% and after intervention, value reduced to about 7.173±2.768%. After the intervention, it was found to be that 30%, 16% and 12% reduction in FBS, PPBS and HbA1c values and the P-value (<0.0001) found to be statistically significant. KAP scores also found to be improved after the intervention and statistically significant. The results clearly indicate that through proper guidance and educating the patients by the pharmacist is beneficial in managing the glycemic levels and reduce further complications. Conclusion: The study concluded that the pharmaceutical care by the pharmacist is highly essentially and useful for the patients to manage the glycemic index and prevent further diabetic complications

Objective assessment of progressive increase in bite force post surgical correction of mandibular fractures using Nupai bite scan analyser

Background: Fracture of mandible is a common condition which is increasing in incidence in the trauma centers due to increasing motor vehicles and failure to abide by traffic regulations. Patients undergo surgical open reduction and internal fixation where post-operative occlusion and normal masticatory functions are targeted. Bite force can be taken as a guide of normal masticatory function of an individual which is dependent upon craniomandibular biomechanics. The aim of the study was to analyse bite force measurements post-operatively in patients who underwent open reduction and internal fixation for mandible fractures at different sites.Methods: Molar bite force was recorded in 31 post-operative patients who underwent open surgical procedure for fracture mandible in the department of plastic surgery from January 2018 to June 2019 by a pre-scale bite force recorder-Nupai bite force prescale system (FujiTM). Various parameters were recorded pre and post-operatively including age, gender, history, comorbidities, requirement of MMF, site and number of fractures and age of injury. Bite force were compared and improvement of bite force every 2 weeks was noted and analyzed upto 6 weeks postoperatively.Results: Bite force improvement was seen in all types of mandible fractures irrespective of the site and type of fractures over a period of 6 weeks post-operatively. This improvement was however not statistically significant. Decreased time interval form injury to surgery resulted in improved bite force measurements though not statistically significant.Conclusions: Although objective improvement in bite force could be demonstrated but extensive study involving more subjects and more patient variables would have statistical significance

Towards a fundamental astrometric reference system behind the Malleganic clouds : spectroscopic confirmation of new quasar candidates selected in the near-infrared

Quasi-stellar objects (quasars) located behind nearby galaxies provide an excellent absolute reference system for astrometric studies, but they are difficult to identify because of fore- and background contamination. We have embarked on a programme to expand the quasar reference system behind the Large and Small Magellanic Clouds, the Magellanic Bridge and Magellanic Stream. Hundreds of quasar candidates were selected, based on their near-infrared colours and variability properties from the ESO VISTA Magellanic Clouds (VMC) Public Survey. A subset of 49 objects was followed up with optical spectroscopy with FORS2. We confirmed the quasar nature of 37 objects (34 new identifications) that span a redshift range from z ~ 0.5 to 4.1

Enhanced Wastewater Remediation Using Mesoporous Activated Wheat Straw Biochars: A Dye Removal Perspective

The escalating contamination of water bodies by synthetic dyes necessitates innovative and ecoconscious strategies for wastewater treatment. In this study, activated biochars BC-800 (1:0.25), BC-800 (1:0.5), and BC-800 (1:1) from wheat straw were synthesized. Here, ratios denote the mass relationship between wheat straw and potassium hydroxide; “800” represents the pyrolysis temperature. These activated biochars were rigorously characterized revealing the most efficient material, BC-800 (1:1), presenting a surface area of 2578.82 m2/g and average pore diameter of 5.51 nm. Across parallel batch experiments, it effectively extracted synthetic dyes (rhodamine B (RhB), methylene blue (MB), and methyl orange (MO)) from wastewater within 15–20 min, primarily through chemisorption pathways. Increased surface area and porosity resulted in a greater dispersion of adsorption sites including C═C linkages (π–π interactions) and H-bonding via surface carbonyl groups (C═O). To understand the adsorption mechanism, Langmuir, Freundlich, and Temkin isotherm models were employed to investigate the equilibrium adsorption behavior. Results show that BC-800 (1:1) followed the Freundlich isotherm (R2: 0.9659 for RhB, 0.9927 for MB, and 0.9979 for MO, respectively), showing dye molecules form multilayers on the surface of the biochar (π-stacking). Biochar recycling through chemical regeneration demonstrated sustained dye removal efficiency >90% for BC-800 (1:1) over multiple cycles

Detailed abundance study of four s-process enriched post-AGB stars in the Large Magellanic Cloud

Context. The photospheric abundances of evolved solar-type stars of different metallicities serve as probes into stellar evolution theory. Aims. Stellar photospheres of post-asymptotic giant branch (post-AGB) stars bear witness to the internal chemical e

Bubble continuous positive airway pressure as a primary modality of respiratory support in meconium aspiration syndrome

Background: Approximately 3–4% of neonates with meconium-stained amniotic fluid (MSAF) develop meconium aspiration syndrome (MAS), of which nearly 30–50% need continuous positive airway pressure (CPAP) or mechanical ventilation (MV). Objective: The objective of the study was to evaluate the usefulness of bubble CPAP as a respiratory support in neonates admitted with MAS and to enumerate factors affecting the CPAP failure. Materials and Methods: A prospective study was conducted, involving all the neonates born with a history of MSAF with respiratory distress within 6 h of life (Downe’s score 4–7), SpO2 <90% with chest X-ray suggestive of MAS. Bubble CPAP was started with pressure and FiO2 adjusted to maintain a SpO2 between 89% and 95%, maximum pressure limit of 6 cm, and FiO2 of 100%, respectively. CPAP was removed when SpO2 was >90% with FiO2 requirement <25% and when respiratory distress was passive (Respiatory rate <60/min, no or mild retractions and no grunt). The primary outcome was measured in terms of improvement in Downe’s score and clinical condition of neonates. CPAP failure was defined as the need for MV, pulmonary leak syndrome, persistent pulmonary hypertension, and progression of Downe’s score. Results: Downe’s score at the start of CPAP was 6 which decreased to 4, 6 h post-CPAP. There was an improvement in FiO2, RR, and heart rate from 68%, 76/min, and 181/min to 84%, 48/min, and 123/min post-CPAP, respectively. The success rate of CPAP was 77% and failure rate was 23%. Conclusion: Early initiation of CPAP in MAS neonates decreases the need for MV and improves outcomes