River Tapi Rejuvenation: Elevating the Ecological Corridor of Surat City

With rapid urban sprawl, comes new challenges to the trends in urbanization. The recent trends in urban development bring urban systems and urban experiences into daily contact with natural habitats. So, it is extremely important to consider natural systems in play while designing for an Urban ecosystem, which is one of the principles of Landscape Urbanism. It is a design practice that intervenes Natural landscape and habitation to form an integrative systems approach. This thesis is built upon approaching an urban riverfront development project through the perspective of Landscape Urbanism. It aims at developing design strategies for the ecological restoration of River Tapi and an environmentally efficient riverfront. The site context is carefully studied and analyzed through literature review, history, mapping analysis, public survey, on-site observation, and activity mapping. The complex concerns that emerge out of context study are strategically organized as a system of categories. Building upon these categories is design interventions to combat those. These interventions are then validated through a prototype site design which can be used as a module to further rejuvenate River Tapi and develop the riverfront

STABILITY STUDY: REGULATORY REQUIRENMENT

Stability is an essential factor of quality, safety and efficacy of a drug product. The objective of stability study is to determine the shelf life, the time period of storage at a specified condition within which the drug product still meets its established specifications. Stability study is of three types that is physical, chemical and microbial stability. Various factors like oxygen, water, temperature, pH, moisture, light and concentration affect the stability. Present work aims to represent the stability testing (ST) requirements of International Conference on Harmonization (ICH), different regulatory agencies like, World Health Organization (WHO), Association of South East Asian Nations (ASEAN) and European Agency for Evaluation of Medicinal and Health Products (EMEA) and difference of those agencies with respect to ICH guideline. Most of the stability requirements for WHO, ASEAN, and EMEA are similar to the ICH guideline, except for the parameters like selection of batches and storage conditions

STABILITY STUDY: REGULATORY REQUIREMENT

Stability is an essential factor of quality, safety and efficacy of a drug product. The objective of stability study is to determine the shelf life, the time period of storage at a specified condition within which the drug product still meets its established specifications. Stability study is of three types that is physical, chemical and microbial stability. Various factors like oxygen, water, temperature, pH, moisture, light and concentration affect the stability. Present work aims to represent the stability testing (ST) requirements of International Conference on Harmonization (ICH), different regulatory agencies like, World Health Organization (WHO), Association of South East Asian Nations (ASEAN) and European Agency for Evaluation of Medicinal and Health Products (EMEA) and difference of those agencies with respect to ICH guideline. Most of the stability requirements for WHO, ASEAN, and EMEA are similar to the ICH guideline, except for the parameters like selection of batches and storage conditions

Springfield\u27s Legacy: A Vision for A Transformative Transit-Oriented Union Station District

This urban design studio developed concepts around equitable transportation Union Station in Springfield, Massachusetts. The work creates a vision for the Union Station District, a revitalized mixed-use walkable neighborhood adjacent to the restored transportation center. It emphasizes reusing the city’s historic street grid in new, forward thinking ways that enhance neighborhood connectivity. The plan creates physical and social networks that bring together diverse groups of residents and visitors. The Union Station District will be a place that offers a range of non-automobile transportation options to residents and visitors and will help transforming an area characterized by vacant lots and empty buildings into a vibrant, well-connected TOD neighborhood. The Union Station District is envisioned as an active, vibrant place that is accessible and inviting to all. KEY GOAL AND MISSION OF THE PROJECT: • Creating a vibrant, connected, equitable neighborhood that reflects Springfield’s diversity KEY DESIGN AND PLANNING OBJECTIVES AND OUTCOMES: Creating places that welcome people of color and traditionally underrepresented communities Promoting public health and community well-being Encouraging bicycling, walking, public transportation and micro-mobility options for all ages including the youth Fostering arts/culture and innovation economy for placemaking/economic development Creating connectivity and mobility for persons with disabilities Provide better connectivity, reusing the existing street grid, and historic infrastructure Include strategies that limit impervious surfaces/stormwater to improve local climat

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84-0.87; P=1.7 × 10(-43)) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

This corrects the article DOI: 10.1038/ncomms5999

Differential expression of antioxidant enzymes under arsenic stress in Enterobacter sp.

Arsenic is a major contaminating heavy metal due to its frequent occurrence and toxicity. Out of different remediation approaches, bioremediation using bacteria has been extensively studied. In this study, 29 bacterial isolates were screened for their arsenic tolerance capacity. One of the isolate, MUM2 showed maximum arsenic tolerance (10mM). Antioxidant enzymes were assayed in this isolate under arsenic stress. Although, the CAT activity was found to increase significantly, the SOD activity showed a significant decrease under 9mM arsenic stress. The results obtained suggest a possible role of CAT in combating arsenic stress. Further studies at genetic level would help in developing highly tolerant strains for remediation of arsenic