Nuclear Track Detectors. Searches for Exotic Particles

We used Nuclear Track Detectors (NTD) CR39 and Makrofol for many purposes: i) Exposures at the SPS and at lower energy accelerator heavy ion beams for calibration purposes and for fragmentation studies. ii) Searches for GUT and Intermediate Mass Magnetic Monopoles (IMM), nuclearites, Q-balls and strangelets in the cosmic radiation. The MACRO experiment in the Gran Sasso underground lab, with ~1000 m^2 of CR39 detectors (plus scintillators and streamer tubes), established an upper limit for superheavy GUT poles at the level of 1.4x10^-16 cm^-2 s^-1 sr^-1 for 4x10^-5 <beta<1. The SLIM experiment at the high altitude Chacaltaya lab (5230 m a.s.l.), using 427 m^2 of CR39 detectors exposed for 4.22 y, gave an upper limit for IMMs of ~1.3x10^-15 cm^-2 s^-1 sr^-1. The experiments yielded interesting upper limits also on the fluxes of the other mentioned exotic particles. iii) Environmental studies, radiation monitoring, neutron dosimetry.Comment: Talk given at "New Trends In High-Energy Physics" (experiment, phenomenology, theory) Yalta, Crimea, Ukraine, September 27-October 4, 200

Magnetic properties and interlayer coupling in Co/V multilayers

The magnetic properties of evaporated Co/V multilayer films have been studied by superconducting quantum interference device magnetometer and ferromagnetic-resonance (FMR). FMR has been used to study the interlayer exchange coupling and the FMR linewidth in Co/V multilayers at room temperature. Spin-waves resonance modes were observed in some Co/V multilayers and the relation of resonant field Hres with the mode number n obeys the so-called n2 law. The interlayer coupling constant was determined. The FMR linewidth, in parallel geometry, of the uniform mode was found to increase with decreasing Co thickness (10Å £ tCo £ 45Å) indicating that it corresponds to an interfacial effect

Time variations in the deep underground muon flux measured by MACRO

More than 30 million of high-energy muons collected with the MACRO detector at the underground Gran Sasso Laboratory have been used to search for flux variations of different natures. Two kinds of studies were carried out: search for periodic variations and for the occurrence of clusters of events. Different analysis methods, including Lomb-Scargle spectral analysis and Scan Test statistics have been applied to the data.Comment: 6 pages, 4 EPS figures. Talk given at the 29th ICRC, Pune, India, 3-10 August 200

A NEW APPROACH TO SYNTHESIS METHACRYLIC MONOMERS N-ALKYLMETHACRYLAMIDE USING AN ECOLOGIC AND FRIENDLY CATALYST MAGHNITE H+

In this paper, we have developed a novel procedure to synthesize four monomers formulated as 1,4-bis(Methacryloyl)Piperazine, N-Methacryloylmorpholine, N-Phenylmethacrylamide and N-Formyldimethacrylamide. N-Alkylmethacrylamide monomers are synthesized by the condensation of primary amine aniline and formamide or heterocyclic secondary amines such as piperazine and morpholine with methacrylic anhydride using an ecologic and friendly catalyst “Maghnite H+”, a proton exchanged montmorillonite clay by replacing a toxic reactant acryloyl chloride and triethylamine which are using in previously published studies. This new approach is even more interesting since this synthesis is carried out in bulk (without solvent) and at 0 °C for 2 hours, obtaining a better yield around 70% and selectivity to the product 100%. These monomers are characterized and confirmed by Infrared Spectroscopy (FTIR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopy

Time variations in the deep underground muon flux

More than 35 million high-energy muons collected with the MACRO detector at the underground Gran Sasso Laboratory have been used to search for flux variations of different nature. Two kinds of studies were carried out: a search for the occurrence of clusters of events and a search for periodic variations. Different analysis methods, including the Scan Statistics test and the Lomb-Scargle spectral analysis have been applied to the data.Comment: 7 pages, 5 figures, accepted by EP

Bulk Etch Rate Measurements and Calibrations of Plastic Nuclear Track Detectors

New calibrations of CR39 and Makrofol nuclear track detectors have been obtained using 158 A GeV Pb (82+) and In (49+) ions; a new method for the bulk etch rate determination, using both cone height and base diameter measurements was developed. The CR39 charge resolution based on the etch-pit base area measurement is adequate to identify nuclear fragments in the interval 7 <= Z/beta <= 49. For CR39 the detection threshold is at REL~50 MeV cm^2/g, corresponding to a nuclear fragment with Z/beta~7. Base cone area distributions for Makrofol foils exposed to Pb (82+) ions have shown for the first time all peaks due to nuclear fragments with Z > 50; the distribution of the etched cone heights shows well separated individual peaks for Z/beta = 78 - 83 (charge pickup). The Makrofol detection threshold is at REL 2700 MeV cm^2/g, corresponding to a nuclear fragment with Z/beta~50.Comment: 11 pages, 5 EPS figures. Submitted to Nucl. Instr. Meth.

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels

Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of this tumour. However, this assumption has yet to be formally tested at a global level. Therefore a genome wide analysis of chromosome copy number and gene expression was performed in tumour cells micro-dissected from the same NPC biopsies. Cellular tumour suppressor and tumour-promoting genes (TSG, TPG) and Epstein-Barr Virus (EBV)-encoded oncogenes were examined. The EBV-encoded genome maintenance protein EBNA1, along with the putative oncogenes LMP1, LMP2 and BARF1 were expressed in the majority of NPCs that were analysed. Significant downregulation of expression in an average of 76 cellular TSGs per tumour was found, whilst a per-tumour average of 88 significantly upregulated, TPGs occurred. The expression of around 60% of putative TPGs and TSGs was both up-and down-regulated in different types of cancer, suggesting that the simplistic classification of genes as TSGs or TPGs may not be entirely appropriate and that the concept of context-dependent onco-suppressors may be more extensive than previously recognised. No significant enrichment of TPGs within regions of frequent genomic gain was seen but TSGs were significantly enriched within regions of frequent genomic loss. It is suggested that loss of the FHIT gene may be a driver of NPC tumourigenesis. Notwithstanding the association of TSGs with regions of genomic loss, on a gene by gene basis and excepting homozygous deletions and high-level amplification, there is very little correlation between chromosomal copy number aberrations and expression levels of TSGs and TPGs in NPC

Experimental Bounds on Masses and Fluxes of Nontopological Solitons

We have re-analyzed the results of various experiments which were not originally interested as searches for the Q-ball or the Fermi-ball. Based on these analyses, in addition to the available data on Q-balls, we obtained rather stringent bounds on flux, mass and typical energy scale of Q-balls as well as Fermi-balls. In case these nontopological solitons are the main component of the dark matter of the Galaxy, we found that only such solitons with very large quantum numbers are allowed. We also estimate how sensitive future experiments will be in the search for Q-balls and Fermi-balls.Comment: 19 pages, 7 eps figures, RevTeX, psfig.st