PAN AIR summary document (version 1.0)

The capabilities and limitations of the panel aerodynamics (PAN AIR) computer program system are summarized. This program uses a higher order panel method to solve boundary value problems involving the Prandtl-Glauert equation for subsonic and supersonic potential flows. Both aerodynamic and hydrodynamic problems can be solved using this modular software which is written for the CDC 6600 and 7600, and the CYBER 170 series computers

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance

Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses. The balance between these two opposing effects is critical in the context of transplantation. Here, we report that female mice deficient in C1q (C1qa(−/−)) or C3 (C3(−/−)) reject male syngeneic grafts (HY incompatible) at an accelerated rate compared with WT mice. Intranasal HY peptide administration, which induces tolerance to syngeneic male grafts in WT mice, fails to induce tolerance in C1qa(−/−) or C3(−/−) mice. The rejection of the male grafts correlated with the presence of HY D(b)Uty-specific CD8(+) T cells. Consistent with this, peptide-treated C1qa(−/−) and C3(−/−) female mice rejecting male grafts exhibited more antigen-specific CD8(+)IFN-γ(+) and CD8(+)IL-10(+) cells compared with WT females. This suggests that accumulation of IFN-γ- and IL-10-producing T cells may play a key role in mediating the ongoing inflammatory process and graft rejection. Interestingly, within the tolerized male skin grafts of peptide-treated WT mice, IFN-γ, C1q and C3 mRNA levels were higher compared to control female grafts. These results suggest that C1q and C3 facilitate the induction of intranasal tolerance

Nurses' implicit and explicit attitudes towards transgender people and the need for trans-affirming care

This is the final version. Available on open access from Elsevier via the DOI in this recordData Availability: The data used in this study can be obtained from the Project Implicit repository on Open Science Framework available at https://osf.io/fb29q/. The codes used for analysis are available from the author's OSF repository at https://osf.io/hscya.BACKGROUND: The primary objective of this study is to investigate the implicit and explicit attitudes of healthcare professionals - in particular nurses - towards transgender people. This is especially important in light of recent calls for improved trans-affirming care provision by healthcare professionals to generate quality healthcare access and outcomes for transgender people. METHODS: We use publicly available data from the transgender version of the Implicit Association Test from 2020 to 2022. We focus on differences between three subsets of participant: (1) non-healthcare professionals (N = 177,810), (2) non-nursing healthcare professionals (N = 22,443) and (3) nursing healthcare professionals (N = 11,996). We present the results of parametric statistical tests (t-tests) and an ordinary least squares regression, to analyse the robustness of our results when controlling for a host of sociodemographic characteristics. RESULTS: We find that non-healthcare professionals have significantly lower implicit bias towards transgender people compared to healthcare professionals. Further, within healthcare professionals, we find nurses have significantly higher implicit bias towards transgender people compared to non-nurses. We show how implicit bias and explicit attitudes are highly correlated. Further, we provide evidence that healthcare professionals - but in particular nurses - conflate sex and gender identity. CONCLUSION: Whilst nurses continue to have higher levels of implicit and explicit bias towards transgender people there remains a need to globally establish additional enhanced trans-affirming care training provision for nursing and medical students

V/STOL lift fan commercial short haul transports: Continuing conceptual design study

A design study of commercial V/STOL transport airplanes for a 1985 operational time period has been made. The baseline mission considered was 400 nmi at a cruise speed of M = 0.75 and a 100-passenger payload with VTOL. Variations from the baseline included mission distance, payload, cruise speed, and propulsion system failure philosophy. All designs used propulsion systems consisting of multiple gas generators driving remote tip turbine lift and lift/cruise fans. By considering the fan to be designed for operational reliability, significant simplication of the airplane systems and reduction in airplane size and cost can be achieved

Notes on the use and interpretation of radiostereometric analysis

ABSTRACT With increasing numbers of research groups carrying out radiostereometric analysis (RSA), it is important to reach a consensus on how the main aspects of the technique should be carried out and how the results should be presented in an appropriate and consistent way

Damage function for historic paper. Part I: Fitness for use

Background In heritage science literature and in preventive conservation practice, damage functions are used to model material behaviour and specifically damage (unacceptable change), as a result of the presence of a stressor over time. For such functions to be of use in the context of collection management, it is important to define a range of parameters, such as who the stakeholders are (e.g. the public, curators, researchers), the mode of use (e.g. display, storage, manual handling), the long-term planning horizon (i.e. when in the future it is deemed acceptable for an item to become damaged or unfit for use), and what the threshold of damage is, i.e. extent of physical change assessed as damage. Results In this paper, we explore the threshold of fitness for use for archival and library paper documents used for display or reading in the context of access in reading rooms by the general public. Change is considered in the context of discolouration and mechanical deterioration such as tears and missing pieces: forms of physical deterioration that accumulate with time in libraries and archives. We also explore whether the threshold fitness for use is defined differently for objects perceived to be of different value, and for different modes of use. The data were collected in a series of fitness-for-use workshops carried out with readers/visitors in heritage institutions using principles of Design of Experiments. Conclusions The results show that when no particular value is pre-assigned to an archival or library document, missing pieces influenced readers/visitors’ subjective judgements of fitness-for-use to a greater extent than did discolouration and tears (which had little or no influence). This finding was most apparent in the display context in comparison to the reading room context. The finding also best applied when readers/visitors were not given a value scenario (in comparison to when they were asked to think about the document having personal or historic value). It can be estimated that, in general, items become unfit when text is evidently missing. However, if the visitor/reader is prompted to think of a document in terms of its historic value, then change in a document has little impact on fitness for use

Near-Field Pressure Signature Splicing for Low-Fidelity Design Space Exploration of Supersonic Aircraft

As interest in supersonic overland flight intensifies, new ways to meet government restrictions on sonic boom loudness must be implemented. Low-fidelity aerodynamic tools, such as PANAIR, can estimate the near-field pressure signature that ultimately determines the loudness of the sonic boom at the ground. These tools can greatly benefit the exploration of large design spaces due to their computational efficiency. One of the limitations of low-fidelity tools is the accuracy of the solution produced, which is dependent on the fundamental physical assumptions made in the development of the governing equations. If flow patterns are produced that severely violate these fundamental assumptions, the validity of the near-field pressure signature is compromised. A method is proposed that splices together near-field pressure signatures from a low-fidelity and a higher-fidelity tool by cutting each pressure signature at a critical point and then blending the low-fidelity signature into the higher-fidelity signature. By splicing the signatures together, sections of the low-fidelity signature that represent fundamental violations of the governing equation are removed. This method allows for the exploration of the design space corresponding to areas on the geometry that produce accurate results in a low-fidelity signature. The method is tested on the JAXA Wing Body geometry from the Second AIAA Sonic Boom Prediction Workshop and shows that perturbations to this geometry can produce loudness results that match the high-fidelity results to within 0.4 PLdB

Caracterização de acessos de pimenta-do-reino com base em sistemas enzimáticos.

Setenta e oito acessos de pimenta-do-reino, incluindo algumas espécies silvestres foram submetidos à análise eletroforética de isoenzimas em gel de poliacrilamida, visando distinguir diferenças fenotípicas que auxiliem na discriminação e seleção dos acessos. Foram utilizados os sistemas enzimáticos SKDH, GOT, ACP, ACO, PGI, FUM, 6PGDH e G6PDH. O polimorfismo de isoenzimas foi avaliado pelo número de alozimas com diferentes mobilidades por sistema enzimático, pelas freqüências de alozimas dentro de cada sistema enzimático em relação ao total de bandas do sistema e pela análise da similaridade genética, com base na ausência e presença de bandas. Todos os sistemas enzimáticos utilizados tiveram boa resolução e definição de bandas, com ênfase para SKDH, 6PGDH, PGI e ACP. Em sua totalidade, os sistemas apresentaram polimorfismo capaz de caracterizar e identificar acessos ou grupos de pequeno número de acessos, sendo que o sistema GOT foi o que apresentou maior variabilidade de alozimas e de perfis; e o que apresentou menor variabilidade foi o sistema FUM, com três alozimas e quatro perfis. Cinqüenta e sete por cento das alozimas podem ser usadas para caracterizar e identificar clones ou grupos de clones. Cerca de 64% dos acessos analisados podem ser identificados por um a seis fenótipos individuais de sistemas enzimáticos. A análise da similaridade indicou os grupos G1, G2 e G3 como os mais divergentes da coleção, os quais são indicados para cruzamentos intraespecíficos e interespecíficos visando a obtenção de clones superiores.Título em inglês: Characterization of black pepper accessions using isozymes. Publicado também on-line

Emerging dietary patterns: impact on child health

What we eat today and how we decide to produce sufficient food to meet both demand and nutritional requirements will determine the availability, diversity and quality of diets for future generations. Acceptability and normalisation of new dietary patterns must be prioritised to the same extent as education on environmental sustainability and health, because these are important social levers. They can help to reduce the psychosocial barriers and anxieties often connected to the behaviour changes that are needed to transition away from the traditional Western eating habits that are now increasingly subject to critical scrutiny. Without understanding the motivations and facilitators to change eating habits (and then designing and amplifying solutions which make those changes attractive and compelling in the modern world) positive changes to young people’s health and their environment through better food will not come quickly enough to halt potentially catastrophic consequences for people and planet. Changing consumption is seen by experts as the most powerful lever compared to food waste reduction or more efficient food production methods and technological solutions. There is simply not enough on Earth to sustain the increase of intensification required to continue feeding a global population on its current trajectory with a diet so rich in animal produce. However, radical behaviour modification is challenging and therefore cross-sector, bold and perhaps unorthodox leadership is necessary to inspire alteration in the food system, which will have a knock-on effect in terms of changing food environments and therefore food perceptions, narratives and behaviours. There are no ‘quick fix’ solutions, but what is undeniable is that populations can only make effective shifts in dietary patterns if government and the food industry help them to make those changes. This requires budgetary investment in public health information and the implementation of policies that promote ways to eat healthily that are also affordable and environmentally sustainable. The aim is to offer food that tastes as good as it can be made to look so that uptake is maximised and the benefits are cumulative. The inevitable upheaval incurred by making any alteration to entrenched patterns of consumption that have been centuries in the making should not be underestimated, but carrying on as before is no longer credible nor desirable. The aim is to offer ‘nutritious’ food. ‘If we don’t take action, the collapse of our civilisations and the extinction of much of the natural world is on the horizon’ Sir David Attenborough. This Report is our initial contribution to a conversation that has only just begun.It is unlikely to be the last