CONTAINER PATCHING AUTOMATION

The present disclosure relates to a method and an automation system for automatically patching a software container. In an embodiment, the present disclosure discloses the aspect of performing pre-validations from Operating System (OS) perspective, and pre-validating cluster/node from Kubernetes perspective and a drain node. Further, the present disclosure discloses patching the node and rebooting the node and performing post-validation from the OS perspective. Additionally, the present disclosure discloses the aspect of post-validating the cluster/node and re-establishing the cluster

PREPARATION, SOLID STATE CHARACTERISATION OF PACLITAXEL AND NARINGEN COCRYSTALS WITH IMPROVED SOLUBILITY

Objective: The objective of the present study is to prepare a better form of paclitaxel cocrystal with improved solubility. Paclitaxel (PTX) is a class-4 drug; this drug has low aqueous solubility and high affinity for P-gp. Available formulation are IV based and using our research work with advantages of co-crystal technology towards the enhancement of paclitaxel solubility and thereby its bioavailability (1) and also to improve the patient compliance. Methods: Naringen was selected based on their chemical nature and its ability to inhibit P-gp, solvent assisted grinding method used to prepare the cocrystals, and prepared cocrystals were subjected to solid state characterization to determine the crystal structure of the cocrystals, as this can provide significant new insights into how the drug and coformer interact, and thereby provide an excellent crystal engineering guide to new cocrystals, potentially with improved properties. Instruments like Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry, X-ray powder diffraction will be used to determine their stability and any phase transformations (including decomposition) which they might undergo as a function of temperature. Results: Principle involved in the formation of cocrystal is hydrogen bonding between C=O and N-H group of drug and COOH groups of coformers, which is confirmed by FTIR data and DSC experiments were carried out to study the melting point and heat of enthalpy of the cocrystals. Results clearly shows that the melting point of the cocrystals was increased which confirms the formation of cocrystals. The drug and formation of cocrystals are explained by the X-ray powder diffraction patterns. The PXRD patterns of the pure drug showed sharp, well-defined peaks(spectrum attached) and cocrystals PXRD patterns shows that there is a significant difference in the entire diffraction pattern, changes in peak locations with respect to pure drug indicates a change in the arrangement of molecules, hence confirms the development of new crystalline phase. Conclusion: The results obtained from the above experiments clearly shows the formation of cocrystals with improved solubility

SYSTEM AND METHOD FOR BUILDING CONTAINER CLUSTER

The present disclosure provides a method and container management system for building container cluster. The container management system based on user requirement may automate hardening of operating system and configure network and storage for adding new container. The container management system obtains and configures load balancer VIP without any manual intervention. Thereafter, the container management system performs end-to-end validation by deploying test application and validating the test application. Thus, the present disclosure reduces time consumption for building container clusters based on the user requirement

A METHOD FOR ADDING IMAGE CLUSTER NODE APIS

The present disclosure discloses a method for adding image cluster node APIs. The objective of the present disclosure is to initiate cluster add node to a Jenkins pipeline by calling the Jenkins APIs. The present disclosure focuses to automatically update the status of the job to the MongoDB. In some embodiments, the present disclosure focuses on adding one or more nodes to the image cluster by initiating Jenkins APIs. Further, the present disclosure includes configuring the cluster files and validating the input data related to new node and initiating capacity add playbook and updating status back to the image cluster

Physio-chemical characterization of three-component co-amorphous systems generated by a melt-quench method

The purpose of this work was to evaluate the possibility of creating a ternary co-amorphous system and to determine how the properties of a co-amorphous material are altered by the addition of a selected third component. Piroxicam and indomethacin form a stable co-amorphous with the Tg above room temperature. The third component added was selected based on tendency to crystallise (benzamide, caffeine) or form amorphous (acetaminophen, clotrimazole) on cooling. Generated co-amorphous systems were characterised with TGA, HSM, DSC, FTIR, and XRD. Stable ternary co-amorphous systems were successfully generated, which was confirmed using XRD, DSC and FTIR analysis. In all cases, Tg of the ternary system was lower than the Tg of the binary system, although higher than that of the individual third compound. Upon storage for 4 weeks all created ternary systems showed significantly smaller variation in Tg compared to the binary system. Stable three-component co-amorphous systems can be generated via melt quench method using either a crystalline or amorphous third component. Addition of third component can alter the Tg of co-amorphous system and in all cases created more stable co-amorphous system upon storage. Physical parameters may not be sufficient in predicting the resulting Tg, therefore knowledge of chemical interaction must be brought into equation as well

Sustainable Secondary Packaging for Life Science Industry : A case study with Cytiva

Sustainable development has become preeminent for government and corporations as the awareness of environmental impact of human activities increases. Integration of sustainability in supply chains requires companies to look at all three pillars of sustainability. Yet, environmental sustainability remains the most prominent and it has popularized terms like carbon footprint and carbon emissions between academics and professionals. Under supply chain, logistics remain a key strategic factor for companies to gain competitive advantage. Packaging fulfills the functional requirements of logistics, marketing, and the environment. This case study, based on active research is conducted using field notes, interviews, participant observation and corporate documents, aims to contribute to the academic field of packaging and sustainability in packaging process, by revealing the relationship between the secondary packaging and transportation emissions, as well as criteria for assessing secondary packaging material for sustainability. This topic is hence relevant and adds on to the current research conducted on packaging logistics and sustainability in secondary packaging. The research is based on existing literature and is supplemented with an empirical case study of a global life science company. The empirical setup enables to explore the relationship between secondary packaging and transportation emissions with a real-life example and enables to create a framework for sustainable assessment of secondary packaging process that focusses on volume optimization and a circular approach.

Sustainable Secondary Packaging for Life Science Industry : A case study with Cytiva

Sustainable development has become preeminent for government and corporations as the awareness of environmental impact of human activities increases. Integration of sustainability in supply chains requires companies to look at all three pillars of sustainability. Yet, environmental sustainability remains the most prominent and it has popularized terms like carbon footprint and carbon emissions between academics and professionals. Under supply chain, logistics remain a key strategic factor for companies to gain competitive advantage. Packaging fulfills the functional requirements of logistics, marketing, and the environment. This case study, based on active research is conducted using field notes, interviews, participant observation and corporate documents, aims to contribute to the academic field of packaging and sustainability in packaging process, by revealing the relationship between the secondary packaging and transportation emissions, as well as criteria for assessing secondary packaging material for sustainability. This topic is hence relevant and adds on to the current research conducted on packaging logistics and sustainability in secondary packaging. The research is based on existing literature and is supplemented with an empirical case study of a global life science company. The empirical setup enables to explore the relationship between secondary packaging and transportation emissions with a real-life example and enables to create a framework for sustainable assessment of secondary packaging process that focusses on volume optimization and a circular approach.