Ethical values of academic nurses: A pilot study

PMID = 2979207

Cultural Validation of the “Use of Intuition by Nursing Students Scale - Turkish version”

PubMed ID: 22865202Purpose: It is well known that intuition ability directly affects patient care quality and outcomes in nursing practice and is therefore an important aspect of nursing education. This study tests the validity and reliability of the Turkish version of the Scale of Use of Intuition by Nursing Students. Design and Methods: The sample for this methodological study was composed of 250 nursing students. Each item of the scale was translated into Turkish by the researchers and validated for Turkish use. Results: The item–total correlation was between.30 and.56 and its Cronbach ? coefficient was.86. There was a statistically significant positive relationship between the level of clinical experience and the total points scored on the physical awareness, emotional awareness, and physical sensations subscales and from the total scale. Conclusions: Based on these results, the Turkish version of the Scale of Use of Intuition by Nursing Students is valid and reliable. © 2012, SAGE Publications. All rights reserved

Factors affecting self-regulated learning in nursing students in turkey

© 2017, Scibulcom Ltd. All rights reserved.This study determined the views of nursing students on the factors affecting self-regulated learning. This study was carried out in the nursing department of Adnan Menderes University in Aydin, Turkey. The sampling consisted of 524 students who agreed to participate in the research. The data were obtained by Student Introduction Form and Self-regulated Learning Skills Scale developed by Turan (2009) in Turkey. Two-way (ANOVA) variance analysis and Independent T test were used in the analysis of the data. Total score average of the students were determined as 149.34 ± 18.92. The meaningful difference between academic success perception and score average of scale total and the whole sub-dimension was found and generally as success level comes down the scale scores decreases. The findings obtained from this study revealed that self-regulated learning skills in nursing students were at medium-level

PREVALENCE OF COMPASSION FATIGUE IN EMERGENCY AND INTENSIVE CARE NURSES IN TURKEY

The aim of this study is to research the prevalence of compassion fatigue among intensive care nurses in a public hospital located in northwestern Turkey. The sample of the study consisted of 111 nurses who worked at adult intensive care units and volunteered for the study. In the collection of research data, demographic questionnaire which includes socio-demographic features and compassion fatigue (CF) sub-scale of Professional Quality of Life Scale (ProQOLR-IV) were used. In the examination, numbers, percentages, mean values, and standard deviations from among descriptive statistics, the Mann Whitney U test, the Kruskal Wallis test, and the Binary logistic regression model were used. In this study, 60.1% of the nurses were found to be in the high risk category with regard to compassion fatigue. Additionally, nurses with high education levels, less occupational experience, and excessive weekly working hours who were single were found to experience higher compassion fatigue risk (p < 0.05). Nurses being supported against the risk of compassion fatigue and coping strategies for this situation being taught to nurses will reflect in their life and work quality positively. Further studies in different specialist fields and areas should be performed in order to incentivize the generalisation of our results and discover other potential predictors

Optimisation of a dosing regime for a topical skin protectant (barrier cream)

Context: Topical skin protectants (barrier creams) have the potential to reduce or enhance the severity of dermal lesions following exposure to allergens or irritants. Therefore, it is essential that such products are subject to appropriate clinical evaluation prior to marketing. Consequently, it is important to accurately define a dosing regime in order to assess test products under appropriate conditions. Objective: In this study, we extended the use of a standard rubefacient (methyl nicotinate; MN) assay to establish the optimum thickness and duration of action of a novel barrier cream (RD1433). White petroleum jelly (Vaseline®) was used as a comparator product. Methods: The dermal response to MN was measured on the volar forearm skin of volunteers (n = 12; average age 47.5 years) using an array of biophysical instruments and visual scoring. When applied at a nominal thickness of 0.1 mm, RD1433 retained effectiveness against MN for up to six hours. In contrast, Vaseline® was relatively ineffective. Moreover, RD1433 provoked no measurable signs of irritation and so can be considered acceptable for further clinical evaluation. Conclusion: Future clinical studies using RD1433 should be based on topical application of a 0.1 mm thickness layer every six hours.Peer reviewe

Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.

MITF-M and PAX3 are proteins central to the establishment and transformation of the melanocyte lineage. They control various cellular mechanisms, including migration and proliferation. BRN2 is a POU domain transcription factor expressed in melanoma cell lines and is involved in proliferation and invasion, at least in part by regulating the expression of MITF-M and PAX3. The T361 and S362 residues of BRN2, both in the POU domain, are conserved throughout the POU protein family and are targets for phosphorylation, but their roles in vivo remain unknown. To examine the role of this phosphorylation, we generated mutant BRN2 in which these two residues were replaced with alanines (BRN2TS→BRN2AA). When expressed in melanocytes in vitro or in the melanocyte lineage in transgenic mice, BRN2TS induced proliferation and repressed migration, whereas BRN2AA repressed both proliferation and migration. BRN2TS and BRN2AA bound and repressed the MITF-M promoter, whereas PAX3 transcription was induced by BRN2TS but repressed by BRN2AA. Expression of the BRN2AA transgene in a Mitf heterozygous background and in a Pax3 mutant background enhanced the coat color phenotype. Our findings show that melanocyte migration and proliferation are controlled both through the regulation of PAX3 by nonphosphorylated BRN2 and through the regulation of MITF-M by the overall BRN2 level

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

International audienceA new efficient type of gadolinium-based theranostic agent (AGuIX) has recently been developed for magnetic resonance imaging (MRI)-guided radiotherapy. These new particles consist of a polysiloxane network surrounded by a number of gadolinium chelates, usually 10. Due to their small size (<5 nm), AGuIX typically exhibit biodistributions that are almost ideal for diagnostic and therapeutic purposes. For example, while a significant proportion of these particles accumulate in tumours, the remainder is rapidly eliminated by the renal route. In addition, these particles present no evidence of toxicity, in the absence of irradiation with up to 10 times the planned dose for clinical trials. AGuIX particles have been proven to act as efficient radiosensitizers in a large variety of experimental in vitro scenarios, including different radioresistant cell lines, irradiation energies, and radiation sources (sensitizing enhancement ratio ranging from 1.1 to 2.5). Preclinical studies have also demonstrated the impact of these particles on different heterotopic and orthotopic tumours, with both intra-tumoural or intravenous injection routes. A significant therapeutical effect has been observed in all contexts. Furthermore, MRI monitoring was proven to efficiently aid in determining a radiotherapy protocol and assessing tumour evolution following treatment. The usual theoretical models, based on energy attenuation and macroscopic dose enhancement, cannot account for all the results that have been obtained. Only theoretical models, which take into account the Auger electron cascades that occur between the different atoms constituting the particle and the related high radical concentrations in the vicinity of the particle, provide an explanation for the complex cell damage and death observed