Statistics in focus INDUSTRY, TRADE AND SERVICES POPULATION AND SOCIAL CONDITIONS

E-skills at a glance.................... 1 Digital literacy is a problem for a large part of the population.. 2 Only a few people atten

Tourism statistics Early adopters of big data? : 2017 edition

El ISSN y el ISBN corresponden a la versión electrónica del documentoThis paper, originally prepared for the 6th UNWTO International Conference on Tourism Statistics, gives an overview of the different sources of big data and their potential relevance in compiling tourism statistics. It discusses the opportunities and risks that the use of new sources can create: new or faster data with better geographical granularity; synergies with other areas of statistics sharing the same sources; cost efficiency; user trust; partnerships with organisations holding the data; access to personal data; continuity of access and output; quality control and independence; selectivity bias; alignment with existing concepts and definitions; the need for new skills, and so on. The global dimension of big data and the transnational nature of companies or networks holding the data call for a discussion in an international context, even though legal and ethical issues often have a strongly local component

MDM4 is a key therapeutic target in cutaneous melanoma.

The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human cancer. However, in melanoma-a highly chemotherapy-resistant disease-TP53 mutations are rare, raising the possibility that this cancer uses alternative ways to overcome p53-mediated tumor suppression. Here we show that Mdm4 p53 binding protein homolog (MDM4), a negative regulator of p53, is upregulated in a substantial proportion (∼65%) of stage I-IV human melanomas and that melanocyte-specific Mdm4 overexpression enhanced tumorigenesis in a mouse model of melanoma induced by the oncogene Nras. MDM4 promotes the survival of human metastatic melanoma by antagonizing p53 proapoptotic function. Notably, inhibition of the MDM4-p53 interaction restored p53 function in melanoma cells, resulting in increased sensitivity to cytotoxic chemotherapy and to inhibitors of the BRAF (V600E) oncogene. Our results identify MDM4 as a key determinant of impaired p53 function in human melanoma and designate MDM4 as a promising target for antimelanoma combination therapy.JOURNAL ARTICLESCOPUS: ar.jinfo:eu-repo/semantics/publishe