Evaluation of hearing and cochlear function by audiometric testing in patients with hyperemesis gravidarum

INTRODUCTION: The aim of this study was to investigate cochlear functions in patients with hyperemesis gravidarum (HG).METHODS: Twenty-nine HG patients (58 ears) and 31 healthy control subjects (62 ears) were included. Audiometry testings at 250 and 500 Hz and 1, 2, 4, 8, 10, 12, 14, 16 kHz were performed to the patients and controls.RESULTS: Mean age of patients with HG was 26,5 ± 4,4 years and the mean age of control group was 28,0 ± 4,2 years. At the time of the tests mean gestational age of the HG group and controls were 9 and 11 weeks respectively. No differences were observed between the groups in tympanic membrane status, or other otolaringological evaluations. No significant differences were observed in audiometric tests at any frequencies between the groups (p values for all > 0.05).CONCLUSION: There was not a difference between pregnant cases with HG and cases with normal pregnancy in terms of audimetric tests. Cochlear functions are not affected remarkably in women with HG

Rigidity Analysis of Protein Molecules

Intrinsic flexibility of protein molecules enables them to change their 3D structure and perform their specific task. Therefore, identifying rigid regions and consequently flexible regions of proteins has a significant role in studying protein molecules' function. In this study, we developed a kinematic model of protein molecules considering all covalent and hydrogen bonds in protein structure. Then, we used this model and developed two independent rigidity analysis methods to calculate degrees of freedom (DOF) and identify flexible and rigid regions of the proteins. The first method searches for closed loops inside the protein structure and uses Gr€ ubler-Kutzbach (GK) criterion. The second method is based on a modified 3D pebble game. Both methods are implemented in a MATLAB program and the step by step algorithms for both are discussed. We applied both methods on simple 3D structures to verify the methods. Also, we applied them on several protein molecules. The results show that both methods are calculating the same DOF and rigid and flexible regions. The main difference between two methods is the run time. It's shown that the first method (GK approach) is slower than the second method. The second method takes 0.29 s per amino acid versus 0.83 s for the first method to perform this rigidity analysis

Evaluation of hearing and cochlear function by audiometric testing in patients with hyperemesis gravidarum

INTRODUCTION: The aim of this study was to investigate cochlear functions in patients with hyperemesis gravidarum (HG).METHODS: Twenty-nine HG patients (58 ears) and 31 healthy control subjects (62 ears) were included. Audiometry testings at 250 and 500 Hz and 1, 2, 4, 8, 10, 12, 14, 16 kHz were performed to the patients and controls.RESULTS: Mean age of patients with HG was 26,5 ± 4,4 years and the mean age of control group was 28,0 ± 4,2 years. At the time of the tests mean gestational age of the HG group and controls were 9 and 11 weeks respectively. No differences were observed between the groups in tympanic membrane status, or other otolaringological evaluations. No significant differences were observed in audiometric tests at any frequencies between the groups (p values for all > 0.05).CONCLUSION: There was not a difference between pregnant cases with HG and cases with normal pregnancy in terms of audimetric tests. Cochlear functions are not affected remarkably in women with HG

The Predictive Value of Precise‑Dapt Score for Mortality in Patients with Acute Decompansed Heart Failure

Introduction: Acute decompensated heart failure (ADHF) is an emergency clinical syndrome defined as a sudden worsening of heart failure.PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent DualAnti‑Platelet Therapy (PRECISE‑DAPT)score is a new scoring used in the management of duration of dual‐antiplatelet therapy after coronary intervention.We presented the hypothesisthatthis scoring can be used as a predictor of mortality in heart failure. Objective:In thisstudy, the correlation between mortality and PRECISE‑DAPTscore will be analyzed in patients diagnosed withADHF. Materials and Methods: A total of 114 patients hospitalized with a diagnosis ofADHFwere included in this study. The patients were divided into two groups: PRECISE‑DAPT score ≥25 and PRECISE‑DAPT score &lt;25, and thesegroups were evaluated in terms of correlation with early (&lt;6 months), late (&gt;6 months) and overall mortality. Results: According to univariateanalysis, it was found that PRECISE‑DAPT score was significantly related with early (P &lt; 0.001), late (P &lt; 0.001), and overall (P &lt; 0.001)mortality. Multivariate Cox regression analysis showed that PRECISE‑DAPT was independently associated with late (hazard ratio: 6.6; 95%confidence interval [CI] 1.6–27.3; P = 0.009) and overall (hazard ratio: 11.3; 95% CI 3.2–40.9; P &lt; 0.001) mortality. According to Kaplan–Meier curve, those with a score of ≥25 were shown to have significantly higher mortality. The predictive ability for the PRECISE‑DAPT scorethreshold value of 25 was investigated in 3 mortality subgroups. Conclusion: The PRECISE‑DAPT score may be a significant independentpredictor of mortality in patients with ADHF. Limitations: This study is subject to the limitations inherent to a retrospective study and thesample size in our study is relatively small.</p

In vitro measurement of ejaculation latency time (ELT) and the effects of vardenafil on ELT on lifelong premature ejaculators: placebo-controlled, double-blind, cross-over laboratory setting

The aim of this study is to measure the ejaculation latency time (ELT) and to evaluate the effects of vardenafil on ELT and rigidity parameters of patients with lifelong premature ejaculation (PE) in a laboratory setting

The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a double-blind laboratory setting study

center dot These findings suggest that PDE5 inhibitors might have some beneficial effects in men with lifelong premature ejaculation

The effects of phosphodiesterase type 5 inhibitors on penile rigidity variables during a period with no sexual stimulation: a laboratory setting double-blind study

What's known on the subject? and What does the study add