46 research outputs found

    Multimodal, Biomaterial-Focused Anticoagulation via Superlow Fouling Zwitterionic Functional Groups Coupled with Anti-Platelet Nitric Oxide Release

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    The functions of anti-fouling, zwitterionic polycarboxybetaine (pCB) and anti-platelet nitric oxide (NO) release replicate key anticoagulant properties of the endothelium. The two approaches, only tested separately thus far, were paired on gas permeable polydimethylsiloxane (PDMS) membranes and evaluated for anti-coagulation. Uncoated PDMS (control) and PDMS coated with pCB were screened for fibrinogen (Fg) fouling followed by platelet adsorption testing to evaluate the effects of coating and/or NO using bioreactors. Bare or coated PDMS membranes separated sheep plasma (108 platelets/ml) and gas flow chambers within the bioreactors. Either 100 or 0 ppm of NO/N2 flowed through the gas chamber for NO release at the plasma/biomaterial interface. Surface-adsorbed platelets were quantified using a lactate dehydrogenase assay after 8 hrs of plasma recirculation. Fg fouling and platelet adsorption on pCB-coated PDMS were 10.40 ± 3.0% of control (

    Comparison of minimized circulation with off-pump coronary artery bypass (OPCAB) grafting and conventional surgery

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    WOS: 000311569100015The development of effective devices for target vessel exposure and stabilization and the subsequent widespread diffusion of off-pump coronary artery bypass (OPCAB) as an alternative technique to conventional on-pump revascularization is discussed. Application of the OPCAB concept for patients with specific cardiac and extracardiac risks and the benefits of avoiding cardiopulmonary bypass (CPB) are explored. The consequences of incomplete revascularization and the high mortality for conversion to CPB are examined. OPCAB with assisted mini-CPB is confirmed as an emerging option which provides an excellent surgical exposure with a stable cardiac output for performing an ideal anastomosis and decreasing the inflammatory deleterious effects of the conventional CPB

    Comparison of minimized circulation with off-pump coronary artery bypass (OPCAB) grafting and conventional surgery (2)

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    The development of effective devices for target vessel exposure and stabilization and the subsequent widespread diffusion of off-pump coronary artery bypass (OPCAB) as an alternative technique to conventional on-pump revascularization is discussed. Application of the OPCAB concept for patients with specific cardiac and extracardiac risks and the benefits of avoiding cardiopulmonary bypass (CPB) are explored. The consequences of incomplete revascularization and the high mortality for conversion to CPB are examined. OPCAB with assisted mini-CPB is confirmed as an emerging option which provides an excellent surgical exposure with a stable cardiac output for performing an ideal anastomosis and decreasing the inflammatory deleterious effects of the conventional CPB. © 2012 Woodhead Publishing Limited. All rights reserved
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