Actinomyces-induced inflammatory myofibroblastic tumor of the colon: A rare cause of an abdominal mass Akbulut et al. inflammatory myofibroblastictumor due to actinomyces spp

AbstractIntroductionInflammatory myofibroblastic tumors (IMFTs) are neoplastic lesions that are either benign or have low-grade malignancy potential. Although the etiopathogenesis is not entirely clear, many factors play a role in their development, including trauma, autoimmune disorders, and infectious and inflammatory processes. However, IMFTs caused by Actinomyces spp. infection are rare, with a limited number of cases reported in the literature.Presentation of caseA 30-year-old woman was admitted to our clinic with abdominal pain and a palpable abdominal mass. Contrast-enhanced computed tomography revealed a tumoral lesion (11×10×7cm) in the right colon. A right hemicolectomy and ileocolic anastomosis were performed, during which almost complete obstruction of the lumen by the 7.5×7.0×5.0cm tumor was observed. Histopathology and immunohistochemical findings revealed that the tumor was consistent with an IMFT that developed from an Actinomyces infection. The patient was then placed on amoxicillin and doxycycline therapy.ConclusionThis case demonstrates that the development of IMFT secondary to actinomycosis is difficult to predict in the preoperative period. Once an exact diagnosis is confirmed by histopathologic examination, affected patients should receive prolonged antibiotherapy

Astronomical Site Selection for Turkey Using GIS Techniques

A site selection of potential observatory locations in Turkey have been carried out by using Multi-Criteria Decision Analysis (MCDA) coupled with Geographical Information Systems (GIS) and satellite imagery which in turn reduced cost and time and increased the accuracy of the final outcome. The layers of cloud cover, digital elevation model, artificial lights, precipitable water vapor, aerosol optical thickness and wind speed were studied in the GIS system. In conclusion of MCDA, the most suitable regions were found to be located in a strip crossing from southwest to northeast including also a diverted region in southeast of Turkey. These regions are thus our prime candidate locations for future on-site testing. In addition to this major outcome, this study has also been applied to locations of major observatories sites. Since no goal is set for \textit{the best}, the results of this study is limited with a list of positions. Therefore, the list has to be further confirmed with on-site tests. A national funding has been awarded to produce a prototype of an on-site test unit (to measure both astronomical and meteorological parameters) which might be used in this list of locations.Comment: 17 pages, 10 figures, accepted by Experimental Astronom

Dudak ve Damak Yarıklı Bir Arkadaşım Var

Bu projeye inandığı ve destek verdiği için, kendisiyle tanışmaktan büyük gurur ve onur duyduğum Prof. Dr. Figen Özgür'e, Bu projenin gerçekleşmesinde büyük katkısı ve emeği olan Doç. Dr. Maviş Kayıkçı'ya, Proje ile ilgili katkı, görüş, fikir ve önerilerini paylaştıkları için; Doç. Dr. Müge Aksu'ya, Yrd. Doç. Dr. Bengisu Akarsu'ya, Uzman Psikolog Meltem Çiğdem Kirazlı'ya, Hacettepe Üniversitesi Dudak ve Damak Yarıkları Konsey Üyeleri'ne, Hikayemin kahramanına ilham kaynağı olduğu için sevgili Erdem Kılıç'a Ve her zaman yanımda oldukları için sevgili annem Nebahat Sakin ve sevgili babam Yaşar Sakin'e, Sonsuz teşekkürler

Dudak Damak Yarıklı Bir Çocuğun Hikayesi

Bu projeye inandığı ve destek verdiği için, kendisiyle tanışmaktan büyük gurur ve onur duyduğum Prof. Dr. Figen Özgür'e, Bu projenin gerçekleşmesinde büyük katkısı ve emeği olan Doç. Dr. Maviş Kayıkçı'ya, Proje ile ilgili katkı, görüş, fikir ve önerilerini paylaştıkları için; Doç. Dr. Müge Aksu'ya, Yrd. Doç. Dr. Bengisu Akarsu'ya, Uzman Psikolog Meltem Çiğdem Kirazlı'ya, Hacettepe Üniversitesi Dudak ve Damak Yarıkları Konsey Üyeleri'ne, Hikayemin kahramanına ilham kaynağı olduğu için sevgili Erdem Kılıç'a Ve her zaman yanımda oldukları için sevgili annem Nebahat Sakin ve sevgili babam Yaşar Sakin'e, Sonsuz teşekkürler

The use of furosemide during Intravenous Immunoglobulin therapy should not always be considered contraindicated

Aims: Endothelial damage in acute respiratory distress syndrome (ARDS) increases capillary permeability, resulting in an increase in free lung fluid, interstitial pulmonary edema, and ventilation-perfusion imbalance. Due to their high osmolarity, Intravenous Immunoglobulin (IVIG) treatment may deepen hypoxemia by increasing lung fluid leakage. Adding furosemide to IVIG treatment in ARDS secondary to COVID-19 (CARDS) cases may increase treatment tolerance and success. Materials and methods: In our study, we aimed to measure the effectiveness of this treatment combination in CARDS cases and to report the observed complications. Patients who were followed up in the 34-bed adult COVID intensive care unit between March 2020/2021 and who received IVIG, high-dose corticosteroid, and furosemide combination therapy were included in the study. Patients' age, gender, comorbidities, Acute Physiology, and Chronic Health Assessment II (APACHE-II), and Sequential Organ Failure Assessment (SOFA) scores were recorded. The day IVIG duration of treatment, additional medical treatments, respiratory support treatments, laboratory examinations, the percentage of involvement of lung lesions (Covid Visual Assessment Scale), clinical outcomes, and treatment complications were recorded. Results: Combination therapy with found to improve respiratory failure in 50 % of patients. Troponin elevation was found in two patients, femoral artery embolism in one patient, and thrombosis in the femoral vein in one patient. In addition to IVIG treatment, the administration of two doses of immune plasma increased the chance of discharge (P = 0.037) Conclusion: In severe viral ARDS refractory to standard therapy, using furosemide in addition to IVIG therapy has an acceptable side-effect profile and may increase treatment success. Furosemide given during IVIG therapy should not be considered a contraindication in every patient

The Role Of Adamts1 And Versican In Human Myocardial Infarction: A Postmortem Study

Objective: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI. Methods: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments. Results: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones. Conclusion: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.WoSScopu

Türkiyede Büyük Teleskoplar İçin GIS Kullanılarak Yer Seçimi Çalışması

Bu çalışmada Türkiye'de potansiyel gözlemevleri için yer seçimi çalışmaları Çok Kriterli Karar Analizi {\itshape (ÇKKA)} ve Coğrafi Bilgi Sistemleri {\itshape (CBS)} içerisinde uydu görüntüleri kullanılarak yapılmıştır. Bulutluluk, Sayısal Yükseklik Modeli, Yapay Işıklılık, Yoğuşabilir Su Buharı miktarı, Aerosol Optik kalınlığı ve rüzgar hızı katmanları CBS içerisinde çalışıldı. ÇKKA'nın sonucu olarak Türkiyedeki en uygun yerlerin güney batıdan kuzey doğuya çizilen bir doğrunun doğu kısmında olduğu belirlendi. Bu bölgeler ileride yapılacak ayrıntılı çalışmalarda birincil adaylardır. Buna ek olarak büyük gözlemevlerimizde çalışılmıştır. Potansiyel gözlemevi adaylarındaki test çalışalarında kullanılacak bir prototip üretilmek üzere bir TUBITAK projesi devam etmektedir