Recent discoveries in the cycling, growing and aging of the p53 field

The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a mediator of the therapeutic effect of anticancer drugs. Still during recent few years even more amazing discoveries have been done. Here we review such topics as suppression of epigenetic silencing of a large number of non-coding RNAs, role of p53 in suppression of the senescence phenotype, inhibition of oncogenic metabolism, protection of normal cells from chemotherapy and even tumor suppression without apoptosis and cell cycle arrest

Recent progress in targeting cancer

In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new original therapeutic strategies to increase potency, selectivity and decrease detrimental side effects have been evaluated. Here we review some recent advances in targeting cancer

Electron-phonon interaction via Pekar mechanism in nanostructures

We consider an electron-acoustic phonon coupling mechanism associated with the dependence of crystal dielectric permittivity on the strain (the so-called Pekar mechanism) in nanostructures characterized by strong confining electric fields. The efficiency of Pekar coupling is a function of both the absolute value and the spatial distribution of the electric field. It is demonstrated that this mechanism exhibits a phonon wavevector dependence similar to that of piezoelectricity and must be taken into account for electron transport calculations in an extended field distribution. In particular, we analyze the role of Pekar coupling in energy relaxation in silicon inversion layers. Comparison with the recent experimental results is provided to illustrate its potential significance

Hypoxia-inducible factor: basic biology and involvement in cardiovascular pathology

Molecular epidemiological studies conducted to date reveal a close relationship between the polymorphism of the HIF system genes with a wide range of cardiovascular, inflammatory, and oncological diseases. The study of the HIF system can contribute to the discovery of new targets and methods of pharmacological effects for the treatment of cardiovascular, oncological, rheumatological, and endocrinological patholog

Study to Investigate the anti-inflammatory effect of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with reference drug Fenspiride (syrup) using accute carrageenan-induced paw inflammation model

Evaluation of anti-inflammatory action of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with Fenspiride was carried out on the model of acute carrageenan inflammation of the paws in rats. As a result of the study, it turned out that obtained data indicate a more pronounced anti-inflammatory activity of Codelac® Broncho with Thymus Serpyllum in comparison with Fenspiride, on the model of acute carrageenan inflammation of the paw in rat

A flexible low-cost, high-precision, single interface electrical impedance tomography system for breast cancer detection using FPGA

Typically, in multi-frequency Electrical Impedance Tomography (EIT) systems, a current is applied and the voltages developed across the subject are detected. However, due to the complexity of designing stable current sources, there has been mention in the literature of applying a voltage to the subject whilst measuring the consequent current flow. This paper presents a comparative study between the two techniques in a novel design suitable for the detection of breast cancers. The suggested instrument borrows the best features of both the injection of current and the application of voltage, circumventing their limitations. Furthermore, the system has a common patient-electrode interface for both methodologies, whilst the control of the system and the necessary signal processing is carried out in a field programmable gate array (FPGA). Through this novel system, wide-bandwidth, low-noise, as well as high-speed (frame rate) can be achieved

Preliminary report on taxonomical position of Vavilovia formosa (Stev.) Fed. evidenced from morphological and molecular data

The Fabeae Rchb. (syn. Vicieae Adans.) tribe includes numerous representatives of special agricultural value and has; therefore, received considerable attention. Despite (or because of) this, there are certain problems concerning its systematics and phylogeny. One of the most problematic groups within the tribe is the monotypic genus Vavilovia Fed. It includes very small perennial plants inhabiting the highlands of the Caucasus, Turkey, Lebanon and Iran. Although almost two centuries have passed since the first description of this plant was reported by C. Steven (more detailed information on the history of its taxonomical status is presented in (1), its status remains unresolved. Previously it was included in the genera Orobus, Lathyrus, Pisum, or treated as a separate genus, Alophotropis Grossh. or Vavilovia Fed. The most recent monographs on the family tend to describe its status as a monotypic genus including a single species, Vavilovia formosa (Stev.) Fed. (2)

Stimulation of reparation in a linear wound model in rats by Bischofit gel

The article is to evaluate Bischofit gel reparative activity in a linear wound model in rat

The cardio- and endothelial protective effects of ethyl methyl hydroxyl pyridine malate in modeling L-name induced nitric oxide deficiency

Currently, endothelial dysfunction is considered as a predictor of a number of pathologies, including arterial hypertension, ischemic heart disease, chronic heart failure, and is also a pathogenetic component of organ damage in diabetes, hypo estrogenic and other conditions. The purpose of the study is an experimental study of the cardio and vasoprotective effects of etoxidol under conditions of endothelial dysfunctio