1,039 research outputs found
Force Modulating Dynamic Disorder: Physical Theory of Catch-slip bond Transitions in Receptor-Ligand Forced Dissociation Experiments
Recently experiments showed that some adhesive receptor-ligand complexes
increase their lifetimes when they are stretched by mechanical force, while the
force increase beyond some thresholds their lifetimes decrease. Several
specific chemical kinetic models have been developed to explain the intriguing
transitions from the "catch-bonds" to the "slip-bonds". In this work we suggest
that the counterintuitive forced dissociation of the complexes is a typical
rate process with dynamic disorder. An uniform one-dimension force modulating
Agmon-Hopfield model is used to quantitatively describe the transitions
observed in the single bond P-selctin glycoprotein ligand
1(PSGL-1)P-selectin forced dissociation experiments, which were respectively
carried out on the constant force [Marshall, {\it et al.}, (2003) Nature {\bf
423}, 190-193] and the force steady- or jump-ramp [Evans {\it et al.}, (2004)
Proc. Natl. Acad. Sci. USA {\bf 98}, 11281-11286] modes. Our calculation shows
that the novel catch-slip bond transition arises from a competition of the two
components of external applied force along the dissociation reaction coordinate
and the complex conformational coordinate: the former accelerates the
dissociation by lowering the height of the energy barrier between the bound and
free states (slip), while the later stabilizes the complex by dragging the
system to the higher barrier height (catch).Comment: 8 pages, 3 figures, submitte
Quenched large deviations for multidimensional random walk in random environment with holding times
We consider a random walk in random environment with random holding times,
that is, the random walk jumping to one of its nearest neighbors with some
transition probability after a random holding time. Both the transition
probabilities and the laws of the holding times are randomly distributed over
the integer lattice. Our main result is a quenched large deviation principle
for the position of the random walk. The rate function is given by the Legendre
transform of the so-called Lyapunov exponents for the Laplace transform of the
first passage time. By using this representation, we derive some asymptotics of
the rate function in some special cases.Comment: This is the corrected version of the paper. 24 page
Effect of Poisson ratio on cellular structure formation
Mechanically active cells in soft media act as force dipoles. The resulting
elastic interactions are long-ranged and favor the formation of strings. We
show analytically that due to screening, the effective interaction between
strings decays exponentially, with a decay length determined only by geometry.
Both for disordered and ordered arrangements of cells, we predict novel phase
transitions from paraelastic to ferroelastic and anti-ferroelastic phases as a
function of Poisson ratio.Comment: 4 pages, Revtex, 4 Postscript figures include
Moderate deviation principle for ergodic Markov chain. Lipschitz summands
For , we propose the MDP analysis for family where
be a homogeneous ergodic Markov chain, ,
when the spectrum of operator is continuous. The vector-valued function
is not assumed to be bounded but the Lipschitz continuity of is
required. The main helpful tools in our approach are Poisson's equation and
Stochastic Exponential; the first enables to replace the original family by
with a martingale while the second to avoid the
direct Laplace transform analysis
A Two-populations Ising model on diluted Random Graphs
We consider the Ising model for two interacting groups of spins embedded in
an Erd\"{o}s-R\'{e}nyi random graph. The critical properties of the system are
investigated by means of extensive Monte Carlo simulations. Our results
evidence the existence of a phase transition at a value of the inter-groups
interaction coupling which depends algebraically on the dilution of
the graph and on the relative width of the two populations, as explained by
means of scaling arguments. We also measure the critical exponents, which are
consistent with those of the Curie-Weiss model, hence suggesting a wide
robustness of the universality class.Comment: 11 pages, 4 figure
Discrete-time classical and quantum Markovian evolutions: Maximum entropy problems on path space
The theory of Schroedinger bridges for diffusion processes is extended to
classical and quantum discrete-time Markovian evolutions. The solution of the
path space maximum entropy problems is obtained from the a priori model in both
cases via a suitable multiplicative functional transformation. In the quantum
case, nonequilibrium time reversal of quantum channels is discussed and
space-time harmonic processes are introduced.Comment: 34 page
Viscous Fingering-like Instability of Cell Fragments
We present a novel flow instability that can arise in thin films of
cytoskeletal fluids if the friction with the substrate on which the film lies
is sufficiently strong. We consider a two dimensional, membrane-bound fragment
containing actin filaments that is perturbed from its initially circular state,
where actin polymerizes at the edge and flows radially inward while
depolymerizing in the fragment. Performing a linear stability analysis of the
initial state due to perturbations of the fragment boundary, we find, in the
limit of very large friction, that the perturbed actin velocity and pressure
fields obey the very same laws governing the viscous fingering instability of
an interface between immiscible fluids in a Hele-Shaw cell. A feature of this
instability that is remarkable in the context of cell motility, is that its
existence is independent of the strength of the interaction between
cytoskeletal filaments and myosin motors, and moreover that it is completely
driven by the free energy of actin polymerization at the fragment edge
Dynamical fluctuations for semi-Markov processes
We develop an Onsager-Machlup-type theory for nonequilibrium semi-Markov
processes. Our main result is an exact large time asymptotics for the joint
probability of the occupation times and the currents in the system,
establishing some generic large deviation structures. We discuss in detail how
the nonequilibrium driving and the non-exponential waiting time distribution
influence the occupation-current statistics. The violation of the Markov
condition is reflected in the emergence of a new type of nonlocality in the
fluctuations. Explicit solutions are obtained for some examples of driven
random walks on the ring.Comment: Minor changes, accepted for publication in Journal of Physics
Random Planar Lattices and Integrated SuperBrownian Excursion
In this paper, a surprising connection is described between a specific brand
of random lattices, namely planar quadrangulations, and Aldous' Integrated
SuperBrownian Excursion (ISE). As a consequence, the radius r_n of a random
quadrangulation with n faces is shown to converge, up to scaling, to the width
r=R-L of the support of the one-dimensional ISE. More generally the
distribution of distances to a random vertex in a random quadrangulation is
described in its scaled limit by the random measure ISE shifted to set the
minimum of its support in zero.
The first combinatorial ingredient is an encoding of quadrangulations by
trees embedded in the positive half-line, reminiscent of Cori and Vauquelin's
well labelled trees. The second step relates these trees to embedded (discrete)
trees in the sense of Aldous, via the conjugation of tree principle, an
analogue for trees of Vervaat's construction of the Brownian excursion from the
bridge.
From probability theory, we need a new result of independent interest: the
weak convergence of the encoding of a random embedded plane tree by two contour
walks to the Brownian snake description of ISE.
Our results suggest the existence of a Continuum Random Map describing in
term of ISE the scaled limit of the dynamical triangulations considered in
two-dimensional pure quantum gravity.Comment: 44 pages, 22 figures. Slides and extended abstract version are
available at http://www.loria.fr/~schaeffe/Pub/Diameter/ and
http://www.iecn.u-nancy.fr/~chassain
The Non--Ergodicity Threshold: Time Scale for Magnetic Reversal
We prove the existence of a non-ergodicity threshold for an anisotropic
classical Heisenberg model with all-to-all couplings. Below the threshold, the
energy surface is disconnected in two components with positive and negative
magnetizations respectively. Above, in a fully chaotic regime, magnetization
changes sign in a stochastic way and its behavior can be fully characterized by
an average magnetization reversal time. We show that statistical mechanics
predicts a phase--transition at an energy higher than the non-ergodicity
threshold. We assess the dynamical relevance of the latter for finite systems
through numerical simulations and analytical calculations. In particular, the
time scale for magnetic reversal diverges as a power law at the ergodicity
threshold with a size-dependent exponent, which could be a signature of the
phenomenon.Comment: 4 pages 4 figure
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