Exploring the removal of online child sexual abuse material in the United Kingdom: processes and practice

This paper explores the processes involved in the removal of online child sexual abuse material. It specifically focuses on the work of the Internet Watch Foundation (IWF) in the UK who are partially responsible for the removal of this content. The empirical work was carried out between May 2017 and September 2017 and explored whether the IWFs processes at removing online child sexual abuse material were both useful and effective to the police and the wider communities. The research applied a mixed methods approach: Semi-structured interviews with employees (N=10) and key stakeholders (N=9), seeking to explore the strengths and challenges of both the task and the IWFs remit. Both employees and stakeholders saw the value in the original and innovative ‘space’ and ‘approach’ the IWF took in removing child sexual abuse material. This included the evolving nature of their tools, from the original URL list filter, to the more adaptable image hashing process. However, challenges around transparency, visibility and partnership were also raised. With online child sexual abuse ever evolving, it is important to consider novel ways in which intervention and prevention of victimization and offending can take place. Where a multi-disciplinary approach is needed in supporting victims, this research provides and insight into how one such organisation uses tools and techniques, different to traditional statutory services or law enforcement responses

Spectral Equivalence of Bosons and Fermions in One-Dimensional Harmonic Potentials

Recently, Schmidt and Schnack (cond-mat/9803151, cond-mat/9810036), following earlier references, reiterate that the specific heat of N non-interacting bosons in a one-dimensional harmonic well equals that of N fermions in the same potential. We show that this peculiar relationship between specific heats results from a more dramatic equivalence between bose and fermi systems. Namely, we prove that the excitation spectrums of such bose and fermi systems are spectrally equivalent. Two complementary proofs are provided, one based on an analysis of the dynamical symmetry group of the N-body system, the other using combinatoric analysis.Comment: Six Pages, No Figures, Submitted to Phys. Rev.

Diel Rhythmicity Found in Behavior but Not Biogenic Amine Levels in the Funnel-Web Spider Agelenopsis pennsylvanica (Araneae, Agelenidae)

Quantifying individual differences in behavior and the extent that behavior is influenced by circadian control is of paramount importance in behavioral ecology. In addition, the proximate mechanisms underlying behavior are also critical in order to obtain a more complete picture of how behavior evolves. Biogenic amines (BAs) are simple nitrogenous compounds derived from amino acids and have been consistently and extensively linked to behavior. For this study, we analyzed temporal patterns of BAs in relation to the antipredator (boldness) and aggressive behavior in female Agelenopsis pennsylvanica, a funnel-web spider. Using HPLC-ED, we compared behavioral responses to temporal patterns of octopamine and serotonin, two BAs known to influence behavior in invertebrates. Our results suggest that, while there was a clear diel cycling pattern of both aggression and boldness, BAs do not follow this same pattern, suggesting that oscillations in absolute levels of BAs are not the underpinnings of behavioral oscillations

Content moderator coping strategies: associations with psychological distress, secondary trauma and wellbeing

Content moderators (CMs) apply policy set by platforms to protect users from harmful content. It is a stressful job, associated with reduced mental health and wellbeing. In this study, an anonymous survey was used to demonstrate most CMs cope by seeking support from colleagues and this is associated with lower psychological distress and secondary trauma and higher wellbeing whereas increased smoking and alcohol consumption is associated with increased symptomology. Wellbeing services were not related to a reduction in psychological distress or trauma. We argue these results fit within a framework of trauma-informed working and provide evidence for its utility in the trust and safety sector. They also highlight the need for continued research into ‘what works’ to support the resilience of frontline staff

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations.

Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles. Very little is known about spatial localization of various drugs in the lipid bilayers, their active form (ionization state) or translocation rates and therefore potency to bind to different sites in membrane proteins. All-atom molecular simulations may help to map drug partitioning kinetics and thermodynamics, thus providing in-depth assessment of drug lipophilicity. As a proof of principle, we evaluated extensively lipid membrane partitioning of d-sotalol, well-known blocker of a cardiac potassium channel Kv11.1 encoded by the hERG gene, with reported substantial proclivity for arrhythmogenesis. We developed the positively charged (cationic) and neutral d-sotalol models, compatible with the biomolecular CHARMM force field, and subjected them to all-atom molecular dynamics (MD) simulations of drug partitioning through hydrated lipid membranes, aiming to elucidate thermodynamics and kinetics of their translocation and thus putative propensities for hydrophobic and aqueous hERG access. We found that only a neutral form of d-sotalol accumulates in the membrane interior and can move across the bilayer within millisecond time scale, and can be relevant to a lipophilic channel access. The computed water-membrane partitioning coefficient for this form is in good agreement with experiment. There is a large energetic barrier for a cationic form of the drug, dominant in water, to cross the membrane, resulting in slow membrane translocation kinetics. However, this form of the drug can be important for an aqueous access pathway through the intracellular gate of hERG. This route will likely occur after a neutral form of a drug crosses the membrane and subsequently re-protonates. Our study serves to demonstrate a first step toward a framework for multi-scale in silico safety pharmacology, and identifies some of the challenges that lie therein

Moderating online child sexual abuse material (CSAM): Does self-regulation work, or is greater state regulation needed?

Social media platforms serve a role in the Internet age as crucial public forums connecting users around the world through a decentralised cyberspace. These platforms host high volumes of content and, as such, the role of content moderators (CMs) employed to safeguard users against harmful content like child sexual abuse material and gore is critical — however, despite how essential CMs are to the social media landscape, their work as “first responders” is complicated by legal and systemic debates over whether policing cyberspace should be left to the self-regulation of tech companies, or if greater state-regulation is required. In this scoping review, major debates in this area are identified and evaluated. This includes the issue of territorial jurisdiction, and how it obstructs traditional policing online; concerns over free speech and privacy if CMs are given greater powers; debates over whether tech companies should be legally liable for user-generated content and; the impacts (mental and professional) on the very CMs now operating as the new frontline against harmful, often traumatic, materials shared on social media. In outlining these issues, our objective is to highlight issues requiring further attention in order to best support CMs, and to enhance responses to harmful online content

Neuron types in the zebrafish optic tectum labeled by an id2b transgene

The larval zebrafish optic tectum has emerged as a prominent model for understanding how neural circuits control visually guided behaviors. Further advances in this area will require tools to monitor and manipulate tectal neurons with cell type specificity. Here, we characterize the morphology and neurotransmitter phenotype of tectal neurons labeled by an id2b:gal4 transgene. Whole-brain imaging of stable transgenic id2b:gal4 larvae revealed labeling in a subset of neurons in optic tectum, cerebellum, and hindbrain. Genetic mosaic labeling of single neurons within the id2b:gal4 expression pattern enabled us to characterize three tectal neuron types with distinct morphologies and connectivities. The first is a neuron type previously identified in the optic tectum of other teleost fish: the tectal pyramidal neuron (PyrN). PyrNs are local interneurons that form two stratified dendritic arbors and one stratified axonal arbor in the tectal neuropil. The second tectal neuron type labeled by the id2b:gal4 transgene is a projection neuron that forms a stratified dendritic arbor in the tectal neuropil and an axon that exits tectum to form a topographic projection to torus longitudinalis (TL). A third neuron type labeled is a projection neuron with a nonstratified dendritic arbor and a descending axonal projection to tegmentum. These findings establish the id2b:gal4 transgenic as a useful tool for future studies aimed at elucidating the functional role of tectum, TL, and tegmentum in visually guided behaviors

Effective s- and p-Wave Contact Interactions in Trapped Degenerate Fermi Gases

The structure and stability of dilute degenerate Fermi gases trapped in an external potential is discussed with special emphasis on the influence of s- and p-wave interactions. In a first step an Effective Contact Interaction for all partial waves is derived, which reproduces the energy spectrum of the full potential within a mean-field model space. Using the s- and p-wave part the energy density of the multi-component Fermi gas is calculated in Thomas-Fermi approximation. On this basis the stability of the one- and two-component Fermi gas against mean-field induced collapse is investigated. Explicit stability conditions in terms of density and total particle number are given. For the single-component system attractive p-wave interactions limit the density of the gas. In the two-component case a subtle competition of s- and p-wave interactions occurs and gives rise to a rich variety of phenomena. A repulsive p-wave part, for example, can stabilize a two-component system that would otherwise collapse due to an attractive s-wave interaction. It is concluded that the p-wave interaction may have important influence on the structure of degenerate Fermi gases and should not be discarded from the outset.Comment: 18 pages, 11 figures (using RevTEX4

Superfluidity in the interior-gap states

We investigate superfluidity in the interior-gap states proposed by Liu and Wilczek. At weak coupling, we find the {\em gapless} interior-gap state unstable in physically accessible regimes of the parameter space, where the superfluid density is shown to be always negative. We therefore conclude that the spatially-uniform interior-gap phase is extremely unstable unless it is fully gapped; in this case, however, the state is rather similar to conventional BCS states.Comment: To appear in Physical Review