Why Does Flow Director Cause Packet Reordering?

Intel Ethernet Flow Director is an advanced network interface card (NIC) technology. It provides the benefits of parallel receive processing in multiprocessing environments and can automatically steer incoming network data to the same core on which its application process resides. However, our analysis and experiments show that Flow Director cannot guarantee in-order packet delivery in multiprocessing environments. Packet reordering causes various negative impacts. E.g., TCP performs poorly with severe packet reordering. In this paper, we use a simplified model to analyze why Flow Director can cause packet reordering. Our experiments verify our analysis

Common ADRB2 Haplotypes Derived from 26 Polymorphic Sites Direct β2-Adrenergic Receptor Expression and Regulation Phenotypes

Background: The β2-adrenergic receptor (β2AR) is expressed on numerous cell-types including airway smooth muscle cells and cardiomyocytes. Drugs (agonists or antagonists) acting at these receptors for treatment of asthma, chronic obstructive pulmonary disease, and heart failure show substantial interindividual variability in response. The ADRB2 gene is polymorphic in noncoding and coding regions, but virtually all ADRB2 association studies have utilized the two common nonsynonymous coding SNPs, often reaching discrepant conclusions. Methodology/Principal Findings: We constructed the 8 common ADRB2 haplotypes derived from 26 polymorphisms in the promoter, 5′UTR, coding, and 3′UTR of the intronless ADRB2 gene. These were cloned into an expression construct lacking a vector-based promoter, so that β2AR expression was driven by its promoter, and steady state expression could be modified by polymorphisms throughout ADRB2 within a haplotype. “Whole-gene” transfections were performed with COS-7 cells and revealed 4 haplotypes with increased cell surface β2AR protein expression compared to the others. Agonist-promoted downregulation of β2AR protein expression was also haplotype-dependent, and was found to be increased for 2 haplotypes. A phylogenetic tree of the haplotypes was derived and annotated by cellular phenotypes, revealing a pattern potentially driven by expression. Conclusions/Significance: Thus for obstructive lung disease, the initial bronchodilator response from intermittent administration of β-agonist may be influenced by certain β2AR haplotypes (expression phenotypes), while other haplotypes may influence tachyphylaxis during the response to chronic therapy (downregulation phenotypes). An ideal clinical outcome of high expression and less downregulation was found for two haplotypes. Haplotypes may also affect heart failure antagonist therapy, where β2AR increase inotropy and are anti-apoptotic. The haplotype-specific expression and regulation phenotypes found in this transfection-based system suggest that the density of genetic information in the form of these haplotypes, or haplotype-clusters with similar phenotypes can potentially provide greater discrimination of phenotype in human disease and pharmacogenomic association studies

Morphological evolution of the mammalian jaw adductor complex

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant transformation of the jaw joint and its incorporation into the middle ear complex. This osteological transformation is accompanied by a rearrangement and modification of the jaw adductor musculature, which is thought to have allowed the evolution of a more-efficient masticatory system in comparison to the plesiomorphic synapsid condition. While osteological characters relating to this transition are well documented in the fossil record, the exact arrangement and modifications of the individual adductor muscles during the cynodont–mammaliaform transition have been debated for nearly a century. We review the existing knowledge about the musculoskeletal evolution of the mammalian jaw adductor complex and evaluate previous hypotheses in the light of recently documented fossils that represent new specimens of existing species, which are of central importance to the mammalian origins debate. By employing computed tomography (CT) and digital reconstruction techniques to create three-dimensional models of the jaw adductor musculature in a number of representative non-mammalian cynodonts and mammaliaforms, we provide an updated perspective on mammalian jaw muscle evolution. As an emerging consensus, current evidence suggests that the mammal-like division of the jaw adductor musculature (into deep and superficial components of the m. masseter, the m. temporalis and the m. pterygoideus) was completed in Eucynodontia. The arrangement of the jaw adductor musculature in a mammalian fashion, with the m. pterygoideus group inserting on the dentary was completed in basal Mammaliaformes as suggested by the muscle reconstruction of Morganucodon oehleri. Consequently, transformation of the jaw adductor musculature from the ancestral (‘reptilian’) to the mammalian condition must have preceded the emergence of Mammalia and the full formation of the mammalian jaw joint. This suggests that the modification of the jaw adductor system played a pivotal role in the functional morphology and biomechanical stability of the jaw joint

Book Review. Palo Alto: A History of California, Capitalism, and the World. Malcolm Harris. New York, Little, Brown and Company, 2023. 720 pp. Saving Time: Discovering a Life Beyond the Clock. Jenny Odell. New York, Random House, 2023. 400 pp

Children of Silicon Valley Turn Toward Marx Review of Palo Alto: A History of California, Capitalism, and the World. Malcolm Harris. New York, Little, Brown and Company, 2023 and Saving Time: Discovering a Life Beyond the Clock. Jenny Odell. New York, Random House, 2023

College Males\u27 Experiences With Group Exercise

Although a comparable number of men use gyms as frequently as women, data indicates that they are less likely to participate in group exercise classes. Although researchers have examined the relationship between gender and group exercise class participation, few studies have explored the linkage in the context of college campuses, specifically how some male participants are still wanting and able to use these services. The purpose of this research project was to examine why and how college men use group exercises classes. Guided by the theory of planned behavior (TPB), the study’s research objectives examined: (1) the exercise trends among college male group exercise participants and college male non-participants; (2) the perceived constraints to group exercise classes among college male participants and non-participants; and (3) the perceived motivations to use group exercise classes among male participants. To address the research objectives, the project relied on a cross-sectional design. Qualitative data were collected by interviewing 20 male students enrolled in a large southeastern university. Of this sample, half were college men who participate in group exercise, while the other half were college men who do not participate in group exercise. Data analysis entailed identifying recurring themes in the data. Friends, social stigma, lack of time, and lack of interest were recurring themes related to perceived constraints. In contrast, consistency and goals were major themes that were found for perceived motivation. The findings within this research study can help create more inclusive spaces and programs within facilities. This can be done by planning programs with males in mind using strategic marketing and more intentional group exercise formats

Molecular studies on nutrient regulation of reproduction and immune responses in a tick

科学研究費助成事業 研究成果報告書：基盤研究(C)2016-2018課題番号 : 16K08094research repor