Neonatal Tumors

Neonatal tumors encompass a group of heterogeneous neoplasms that demonstrate anatomic locations, behavior patterns, histologic features, and treatment responses that are distinct from neoplasms found in older children. The majority of neonatal tumors are benign, with malignant lesions accounting for only 2% of childhood cancers. However, histologically benign tumors can lead to detrimental effects on the fetus and newborn due to their size and location in relation to vital structures. An understanding of the incidence, appearance, and typical locations of neonatal tumors can provide important diagnostic information and guide treatment decisions. Although surgical intervention is the mainstay of therapy for many neonatal tumors, it is important to recognize that some lesions will regress spontaneously, whereas others may respond to noninvasive treatment modalities. In this chapter, we explore the epidemiology of neonatal tumors and provide a location-based classification schema to aid in diagnosis. A summary of the presentation, diagnosis, and management of the most common neonatal tumors is provided as well

Therapists or Helpers? Notes on a Youth-Type Free Clinic

This paper builds upon a helpful typology of free clinics that divides then into four major kinds - the street, neighborhood, youth, and sponsored. While the typology tends to weave among characteristics of clientele, locale, and source of support in setting up its units, it nonetheless has the advantage of being based on an empirical assessment of the major forms of clinic operations through the country. Youth clinics - the type that particularly concerns us here - are defined as generally organized by adults, service clubs, or official boards... because of their concern about drug use among high school students. Such clinics are distinctive from the other types in that they generally offer drug care which is limited to education and counseling. Our examination of the youth clinic model attempts to determine its distinctive characteristics vis-a-vis the remaining types of programs. In this regard, we hope to move information and insights about free clinics beyond the head-counting, diagnosis-tabulating stage and the sometimes (and quite understandable) self-congratulatory observations that have surrounded the early, innovative period of the free clinic movement

Rex E. Lee Conference on the Office of the Solicitor General of the United States: Panel for Former Solicitors General

I agree entirely that the chain of command is clear and that the Framers managed to make it all the way through all the articles of the Constitution without even conceiving of a solicitor general, let alone bothering to mention an attorney general. It is important nonetheless to distinguish between those things the solicitor general does pursuant to the longstanding notice-and-comment regulation, and the other things a solicitor general may do pursuant to his (and, someday, her!) statutory obligation to be of general assistance to the attorney general

Rhenium elemental and isotopic variations at magmatic temperatures

Recent analytical advances in the measurement of rhenium (Re) isotope ratios allow its potential as a palaeoredox and chemical weathering proxy to be explored. However, a successful isotopic proxy must be grounded by an understanding of its composition and behaviour in the solid Earth. Here, we present Re concentrations and Re isotopic (δ187Re) compositions for a well-characterised sequence of lavas from Hekla volcano, Iceland. The concentration of Re varies from 0.02 to 1.4 ng/g, decreasing from basalt to more evolved lavas. We show that the crystallisation and removal of magnetite is responsible for the Re decrease in this system. By contrast, δ187Re values for the same suite of samples show a relatively narrow range (−0.45 to −0.22 ‰), suggesting minimal resolvable Re isotope fractionation between magnetite and the silicate melt. Together with other samples, including mid-ocean ridge basalts, these first igneous data can be used to estimate a baseline for terrestrial materials (δ187Re = −0.33 ± 0.15 ‰, 2 s.d., n = 14), from which low-temperature Re isotope variations in Earth’s surficial environments can be assessed, alongside the global isotope mass balance of Re

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD⁺) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD⁺ in whole blood demonstrated that NRPT significantly increases the concentration of NAD⁺ in a dose-dependent manner. NAD⁺ levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD⁺ levels was sustained throughout the entire 8-week trial. NAD⁺ levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD⁺ levels sustainably

Rhenium elemental and isotopic variations at magmatic temperatures

This work was funded by Natural Environment Research Council UK Standard Grant to RGH, AJD, and JP (NE/T001119).Recent analytical advances in the measurement of rhenium (Re) isotope ratios allow its potential as a palaeoredox and chemical weathering proxy to be explored. However, a successful isotopic proxy must be grounded by an understanding of its composition and behaviour in the solid Earth. Here, we present Re concentrations and Re isotopic (δ187Re) compositions for a well-characterised sequence of lavas from Hekla volcano, Iceland. The concentration of Re varies from 0.02 to 1.4 ng/g, decreasing from basalt to more evolved lavas. We show that the crystallisation and removal of magnetite is responsible for the Re decrease in this system. By contrast, δ187Re values for the same suite of samples show a relatively narrow range (−0.45 to −0.22 0/1000), suggesting minimal resolvable Re isotope fractionation between magnetite and the silicate melt. Together with other samples, including mid-ocean ridge basalts, these first igneous data can be used to estimate a baseline for terrestrial materials (δ187Re = −0.33 ± 0.15 0/1000, 2 s.d., n = 14), from which low-temperature Re isotope variations in Earth’s surficial environments can be assessed, alongside the global isotope mass balance of Re.Peer reviewe