The social neuroscience and the theory of integrative levels

Frontiers in Integrative Neuroscience 9 (2015): A054 This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionThe theory of integrative levels provides a general description of the evolution of matter through successive orders of complexity and integration. Along its development, material forms pass through different levels of organization, such as physical, chemical, biological or sociological. The appearance of novel structures and dynamics during this process of development of matter in complex systems has been called emergence. Social neuroscience (SN), an interdisciplinary field that aims to investigate the biological mechanisms that underlie social structures, processes, and behavior and the influences between social and biological levels of organization, has affirmed the necessity for including social context as an essential element to understand the human behavior. To do this, SN proposes a multilevel integrative approach by means of three principles: multiple determinism, nonadditive determinism and reciprocal determinism. These theoretical principles seem to share the basic tenets of the theory of integrative levels but, in this paper, we aim to reveal the differences among both doctrines. First, SN asserts that combination of neural and social variables can produce emergent phenomena that would not be predictable from a neuroscientific or social psychological analysis alone; SN also suggests that to achieve a complete understanding of social structures we should use an integrative analysis that encompasses levels of organization ranging from the genetic level to the social one; finally, SN establishes that there can be mutual influences between biological and social factors in determining behavior, accepting, therefore, a double influence, upward from biology to social level, and downward, from social level to biology. In contrast, following the theory of integrative levels, emergent phenomena are not produced by the combination of variables from two levels, but by the increment of complexity at one level. In addition, the social behavior and structures might be contemplated not as the result of mixing or summing social and biological influences, but as emergent phenomena that should be described with its own laws. Finally, following the integrative levels view, influences upward, from biology to social level, and downward, from social level to biology, might not be equivalent, since the bottom-up processes are emergent and the downward causation (DC) is notThis work was funded by the Spanish Ministry of Science (BFU2011-29089) to JMD-

Genes for asparagine metabolism in Lotus japonicus : differential expression and interconnection with photorespiration

Background: Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability. Asparagine intracellu lar concentration depends on a balance between asparagine biosynthesis and degradation. The main enzymes involved in asparagine metabolism are as paragine synthetase (ASN), asparaginase (NSE) and serine-glyoxylate aminotransfera se (SGAT). The study of the genes encoding for these enzymes in the model legume Lotus japonicus is of particular interest since it has been proposed that asparagine is the principal molecule used to transport reduced nitrogen within the plant in most temperate legumes. Results: A differential expression of genes encoding for seve ral enzymes involved in asparagine metabolism was detected in L. japonicus . ASN is encoded by three genes, LjASN1 was the most highly expressed in mature leaves while LjASN2 expression was negligible and LjASN3 showed a low expression in this organ, suggesting that LjASN1 is the main gene responsible for asparagine synthesis in mature leaves. In young leaves, LjASN3 was the only ASN gene expressed although at low levels, while all the three genes encoding for NSE were highly expressed, especially LjNSE1 .Innodules, LjASN2 and LjNSE2 were the most highly expressed genes, suggesting an important role for these genes in this organ. Several lines of evidence support the connection between asparagine metabolic genes and photorespiration in L. japonicus : a) a mutant plant deficient in LjNSE1 showed a dramatic decrease in the expression of the two genes encoding for SGAT; b) expression of the genes involved in asparagine metabolism is altered in a photorespiratory mutant lacking plastidic glutamine synthetase; c) a clustering analysis indicated a similar pattern of expression among several genes involved in photorespiratory and asparagine metabolism, indicating a clear link between LjASN1 and LjSGAT genes and photorespiration. Conclusions: The results obtained in this paper indicate the exis tence of a differential expression of asparagine metabolic genes in L. japonicus and point out the crucial relevance of particular genes in different organs. Moreover, the data presented establish clear links betw een asparagine and photorespiratory metabolic genes in this plant.Junta de Andalucía (P10-CVI- 6368)FEDER-Ministerio de Economía y Competitividad (AGL 2014 – 54413-R

Análisis de la población, vivienda y comercio en Valladolid y los municipios de su alfoz

Informe sobre el estado y perspectivas de la población, comercio y vivienda en Valladolid y su entorno.Departamento de Geografí

Neuronal Premotor Networks Involved in Eyelid Responses: Retrograde Transneuronal Tracing with Rabies Virus from the Orbicularis Oculi Muscle in the Rat

Retrograde transneuronal tracing with rabies virus from the right orbicularis oculi muscle was used to identify neural networks underlying spontaneous, reflex, and learned blinks. The kinetics of viral transfer was studied at sequential 12 hr intervals between 3 and 5 d after inoculation. Rabies virus immunolabeling was combined with the immunohistochemical detection of choline acetyltransferase expression in brainstem motoneurons or Fluoro-Ruby injections in the rubrospinal tract. Virus uptake involved exclusively orbicularis oculi motoneurons in the dorsolateral division of the facial nucleus. At 3-3.5 d, transneuronal transfer involved premotor interneurons of trigeminal, auditory, and vestibular reflex pathways (in medullary and pontine reticular formation, trigeminal nuclei, periolivary and ventral cochlear nuclei, and medial vestibular nuclei), motor pathways (dorsolateral quadrant of contralateral red nucleus and pararubral area), deep cerebellar nuclei (lateral portion of interpositus nucleus and dorsolateral hump ipsilaterally), limbic relays (parabrachial and Kölliker-Fuse nuclei), and oculomotor structures involved in eye-eyelid coordination (oculomotor nucleus, supraoculomotor area, and interstitial nucleus of Cajal). At 4 d, higher order neurons were revealed in trigeminal, auditory, vestibular, and deep cerebellar nuclei (medial, interpositus, and lateral), oculomotor and visual-related structures (Darkschewitsch, nucleus of the posterior commissure, deep layers of superior colliculus, and pretectal area), lateral hypothalamus, and cerebral cortex (particularly in parietal areas). At 4.5 and 5 d the labeling of higher order neurons occurred in hypothalamus, cerebral cortex, and blink-related areas of cerebellar cortex. These results provide a comprehensive picture of the premotor networks mediating reflex, voluntary, and limbic-related eyelid responses and highlight potential sites of motor learning in eyelid classical conditioning

European consensus of criteria for the evaluation of good practices in chronic conditions

Los sistemas sanitarios reconocen las enfermedades crónicas como uno de sus grandes desafíos de salud del siglo XXI para los sistemas sanitarios. A pesar de ser en gran medida prevenibles, las enfermedades crónicas son importante causa de mortalidad y morbilidad en Europa. En 2015, más de 1,2 millones de personas en los países de la UE murieron por enfermedades y lesiones que podrían haberse evitado a través de políticas de salud pública más fuertes o de una atención médica más efectiva y menos fragmentada. La presente tesis doctoral reporta el desarrollo y resultados de una proceso de consenso internacional cuyo objetivo ha sido desarrollar criterios de evaluación para valorar el potencial de las prácticas clínicas e intervenciones y políticas sanitarias a la hora de disminuir la carga atribuible a las enfermedades crónicas en cuatro áreas de interés: Promoción de la salud y prevención primaria de condiciones crónicas; Intervenciones organizativas enfocadas al tratamiento de pacientes crónicos con condiciones clínicas múltiples; Intervenciones sobre el empoderamiento del paciente; e, Intervenciones y políticas orientadas a mejorar la diabetes (la diabetes se utiliza como condición paradigmática). Con objeto de acordar los criterios de evaluación y otorgarles relevancia distinta en función del dominio de interés, se desarrolló un consenso internacional mediante la técnica Delphi-modificada, en la que participaron 113 expertos de diferentes disciplinas procedentes de 23 países europeos. El proceso de consenso produjo 145 categoría de evaluación (28 categorías en el Delphi de Health promotion and primary prevention of chronic conditions, 50 en el de Organizational interventions aimed at dealing with complex chronic patients with multiple conditions, 28 en el de Patient empowerment interventions with chronic conditions y 39 categorías en el Delphi de diabetes as a case-study) orientadas a valorar cada uno de los citados dominios y ponderarlos en función de cada área de interés. El conjunto de criterios y categorías acordados para el caso paradigmático de Diabetes apoya la hipótesis de que los criterios de valoración son transferibles y aplicables a la evaluación de prácticas, intervenciones y políticas desarrolladas sobre otras condiciones crónicas. Consistentemente con lo observado en otras iniciativas europeas, en este consenso, los criterios relacionados con ‘diseño de la práctica’, ‘evaluación’, ‘sostenibilidad’ y ‘escalabilidad’ parecen ser componentes esenciales en el desarrollo e implementación de buenas prácticas en Europa. Por último, como virtualidad destacable de este proceso de consenso, el componente internacional de las decisiones consensuadas, apoya la posibilidad de que las prácticas evaluadas con los criterios y categorías acordados puedan ser transferidas a cualquier contexto europeo.<br /

Learning environments in compulsory secondary education (ESO): validation of the physical, learning, teaching and motivational scales

We present the validation of a questionnaire for compulsory secondary school students (seventh to tenth grade), designated “Educational learning environments for ESO pupils” (CEApA_ESO), for the purpose of evaluating learning environments. Although many instruments have been developed in this area, our work attempts to comprehensively cover some factors that most influence learning environments from the students’ perspective. Therefore, we included physical, learning, teaching and motivational elements, by adapting different already-validated scales to our intended overall approach and the Spanish context. We conducted a pilot study with 207 students from four grades (two classes per educational level). We performed descriptive and factor analyses with maximum likelihood extraction method and varimax rotation to identify factors underlying each scale. The factors extracted from each scale were used to evaluate the fit of the model, using the AMOS v.18 software for structural equation analysis, taking as reference the criteria set by Byrne (Structural equation modeling with AMOS: Basic concepts, applications, and programming, Taylor & Francis Group, 2010) and Kline (Principles and practice of structural equation modeling, The Guilford Press, 2010) (CMIN/DF between 2 and 5, CFI and IFI > 0.9, RMSEA 200). Finally, we present the factorial validity of the complete scale and analyse the internal consistency of the scale and its subscales using Cronbach’s alpha coefficient. This instrument, with adequate psychometric properties, offers educators and researchers a valid tool for assessing the learning environments of their schools.Funding for open access publishing: Universidad de Huelva /CBUA. The information we are collecting is part of the project entitled: “Analysis of learning environments in secondary schools in Andalusia. Quantitative study.” (Ref: UHU-1256187), within the call for ERDF projects financed by the European Union, Junta de Andalucía and Universidad de Huelva. This project is led by Dr. María del Pilar García Rodríguez and Dr. José Manuel Coronel Llamas

Ontogeny regulates creatine metabolism in rat small and large intestine

The ontogeny of intestinal CRT, AGAT and GAMT was investigated in foetuses, newborn, suckling, weaning and adult rats. In the colon, CRT mediates creatine transport because it was Na+- and Cl—dependent and inhibited by creatine and GPA. In addition, Northern assays showed two CRT transcripts (2.7-kb and 4.2-kb) and the in situ hybridisation revealed that CRT mRNA is restricted to the colon epithelial cells. The immunohistochemistry revealed that CRT protein was at the apical membrane of colon epithelia. Maturation decreased colonic CRT activity to undetectable levels and increased CRT mRNA abundance. Western assays revealed 57-, 65-, 80- and 116-kDa polypeptides at the intestinal apical membrane. The abundance of the 65-, 80- and 116-kDa polypeptides decreased with age, and that of 57-kDa was only observed in adult rats. The small and large intestine express AGAT and GAMT mRNAs. Maturation decreased AGAT mRNAabundance without affecting that of GAMT. For comparison, renal AGAT mRNAlevels were measured and they were increased with age. The study reports for the first time that: i) the apical membrane of rat colon have an active CRT, ii) development down-regulates CRT activity via post-transcriptional mechanism(s), iii) the intestine might synthesize creatine and iv) intestinal and renal creatine synthesis is ontogenically regulated at the level of AGAT gene expression

Impact of gold-mining activity on trace elements enrichment in the West African estuaries: The case of Pra and Ankobra rivers with the Volta estuary (Ghana) as the reference

This study aimed at assessing trace element concentrations in two representative estuaries of Ghana (Pra and Ankobra) affected by gold-mining, relative to the levels of the unaffected Volta estuary. Surficial sediments (n = 16–17) were sampled at each estuary and analysed by ICP-MS for 25 elements after pseudo-total digestion. The enrichment and geoaccumulation indexes revealed a moderate to significant contamination of As, Ag and Cu in the Pra and Ankobra estuaries. Spatial maps of concentrations revealed non-localized sources. High As concentrations were attributable to runoff transport and sedimentation of gold mining-tailing particles, as suggested by results from granulometric distributions, correlation and PCA analysis. The probabilities of surpassing the probable effects level (PEL) were 77% for As, 50% for Cr and 27% for Ni in Ankobra; these values were of 13%, 23% and 10% for the Pra. Results reveal potential future implications on ecosystems and human health in these both estuaries as result of the gold-mining activity.International Atomic Energy Agency Research Project RAF7009Ministerio de Economía y Competitividad AGl2014-57835-C2-1-

Conditional Reasoning: Scenario or Context Effects?

This Paper was presented at the Fifth Conference of the European Society for Cognitive Psychology - ESCOP, celebrated in Paris, Societé Francaise de Psychologie-Université de Paris-SUD (September, 12-16, 1992).This paper studies the importance of contextual factors in reasoning with conditional inference tasks. In this experiment subjects were given conditional sentences in the context of narrative texts. Short stories about scenarios of the daily life were described in these texts. The experiment manipulated: a) context (causal or promises/threats), b) degree of factual relation between antecedent and consequent of conditional (deterministic, probabilistic or without relation), c) congruence between the factual consequence explicit in the story and the logic conclusion and d) conditional rules. The results were related to previous investigations about syllogistic inference (Valiña & De Vega, 1988) and were discussed within the framework of theoretical modes about pragmatic reasoning

Análisis de la población, vivienda y comercio en Valladolid y los municipios de su alfoz

Producción CientíficaEstudio sobre la evolución de la población y la vivienda en el área comercial de la ciudad de Valladolid , sus dotaciones comerciales y desequilibrios espaciales, con el objetivo de fijar las necesidades de nuevas grandes superficies de distribución al por menor sin menoscabar el papel del pequeño comercio minorista, aplicando una gestión coordinada e integral del territorio periurbano.GEOGRAFÍAInforme encargado por IDOM