Cytogenetic characterization of the genome of mealybug Planococcus citri (Homoptera, Coccoidea)

Summary Mealybugs although being agriculturally harmful insects have been very poorly studied by modern cytogenetics techniques, and no cytotaxonomic criteria to distinguish between closely related species is available yet. In the mealybug Planococcus citri (2n=10) male and female individuals are both diploid, however in males, at the stage of blastula, the haploid chromosome set of paternal origin becomes heterochromatic, even though its complete inertia has been considered questionable. Here we present data on the cytogenetic characterization of the chromosomes of Planococcus citri. We report on (i) the fluorescence karyotype (D287/170), which to our knowledge is the first banded karyotype of a mealybug to be described; (ii) the chromosome localization of constitutive heterochromatin; (iii) the chromosome localization of rDNA sites; (iv) NORs activity. Our data also show, for the first time, that in the heterochromatic chromosome set ribosomal genes are still active

Erectile dysfunction in patients taking psychotropic drugs and treated with phosphodiesterase-5 inhibitors

Objectives: The aim of this study was to assess the prevalence of patients with Erectile Dysfunction (ED) receiving psychotropic drugs, the impact of these drugs on hormonal profile, and the efficacy of PDE5-i in these patients. Materials and methods: We recruited 1872 patients referring for ED to our Andrology Unit. Assessment included serum testosterone, gonadotropins, TSH, prolactin, and PSA, and the IIEF-5 questionnaire for ED diagnosis. Inclusion criteria were age 21-75 years and IIEF-5 total score ≤ 21; exclusion criteria included hypogonadism, diabetes mellitus, previous prostatectomy, other medication intake, and ED diagnosis prior to psychotropic drug treatment. Efficacy was rated with the IIEF-5 (remission: total score ≥ 22). Results: The prevalence of ED patients treated with psychotropic drugs since ≥ 3 months was 9.5% (178/1872), subdivided according to the drugs used into: Group A, 16 patients treated with atypical antipsychotics (9.0%); Group B, 55 patients with benzodiazepines (30.9%); Group C, 33 patients with antidepressant drugs (18.5%); and Group D, 74 patients with multiple psychotropic drugs (41.6%). Patients in Group A were significantly younger than other groups (p < 0.05). The hormonal profile presented only higher prolactin level in patients treated with antipsychotics, alone or in combination (p < 0.05). Overall, 146 patients received PDE5-i. Remission rate, after three months of treatment, was significantly higher in Group B compared to C and D groups (p < 0.05). Conclusions: A substantial portion of patients receiving psychotropic drugs show ED. Sexual performance in these patients benefits from PDE5-i. Age, effects of psychiatric disorders, psychotropic drugs, and PDE5-i treatment modality accounted for variability of response in this sample

Entanglement evolution and generalised hydrodynamics: noninteracting systems

The large-scale properties of homogeneous states after quantum quenches in integrable systems have been successfully described by a semiclassical picture of moving quasiparticles. Here we consider the generalisation for the entanglement evolution after an inhomogeneous quench in noninteracting systems in the framework of generalised hydrodynamics. We focus on the protocol where two semi-infinite halves are initially prepared in different states and then joined together, showing that a proper generalisation of the quasiparticle picture leads to exact quantitative predictions. If the system is initially prepared in a quasistationary state, we find that the entanglement entropy is additive and it can be computed by means of generalised hydrodynamics. Conversely, additivity is lost when the initial state is not quasistationary; yet the entanglement entropy in the large-scale limit can be exactly predicted in the quasiparticle picture, provided that the initial state is low entangled

Reshaping ophthalmology training after COVID-19 pandemic

Background The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on practical activities and didactic teaching of residents and fellows. This survey aimed to propose long-term changes for ophthalmology training based on the changes experienced by trainees and their perception of new training opportunities. Methods An online survey was distributed to ophthalmology trainees in multiple countries. Descriptive statistics were used to analyse the data. Results A total of 504 analyzable responses were collected from 32 different countries. The current impact of COVID-19 pandemic was described as "severe" by most trainees (55.2%); however, the future perspective was more optimistic as demonstrated by the greater number of responses reporting a presumed "moderate" (37.3%), "mild" (14.1%) or "slight" (4.2%) long-term impact. The vast majority of trainees reported a decrease &gt;= 50% of clinical activity (76.4%) and &gt;75% of surgical activity (74.6%). Although an initial gap in didactic teaching has been experienced by many (55.4%), regular web-based teaching was reportedly attended by 67.7% of the respondents. A strong agreement was found regarding the worthwhile role of web-based case-presentations in clinical training (91.7%), web-based discussion of edited surgical videos (85.7%) and simulation-based practice (86.9%) in surgical training. Conclusions This survey, focusing on trainees' perspective, strongly reinforces the need to promptly include new technology-based training tools, such as web-based teaching, virtual surgical simulators, and telementoring, in long-term reorganisation of ophthalmology training to ensure its continuity and effectiveness, which would remain available even in the face of another unpredictable crisis within the health system

Reshaping ophthalmology training after COVID-19 pandemic

Background: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on practical activities and didactic teaching of residents and fellows. This survey aimed to propose long-term changes for ophthalmology training based on the changes experienced by trainees and their perception of new training opportunities. Methods: An online survey was distributed to ophthalmology trainees in multiple countries. Descriptive statistics were used to analyse the data. Results: A total of 504 analyzable responses were collected from 32 different countries. The current impact of COVID-19 pandemic was described as “severe” by most trainees (55.2%); however, the future perspective was more optimistic as demonstrated by the greater number of responses reporting a presumed “moderate” (37.3%), “mild” (14.1%) or “slight” (4.2%) long-term impact. The vast majority of trainees reported a decrease ≥50% of clinical activity (76.4%) and >75% of surgical activity (74.6%). Although an initial gap in didactic teaching has been experienced by many (55.4%), regular web-based teaching was reportedly attended by 67.7% of the respondents. A strong agreement was found regarding the worthwhile role of web-based case-presentations in clinical training (91.7%), web-based discussion of edited surgical videos (85.7%) and simulation-based practice (86.9%) in surgical training. Conclusions: This survey, focusing on trainees’ perspective, strongly reinforces the need to promptly include new technology-based training tools, such as web-based teaching, virtual surgical simulators, and telementoring, in long-term reorganisation of ophthalmology training to ensure its continuity and effectiveness, which would remain available even in the face of another unpredictable crisis within the health systempublishersversionPeer reviewe

Pebbles and avalanches

This joint exhibition of ten artists from the University of Lincoln was curated by Clare Charnley and used artworks to draw attention to the complex dynamics of the two-way process of influence between teachers and students of art. This show included stills from one of my video pieces - ‘Domain of formlessness’, which was inspired by Steve Dutton whom I met whilst doing my Masters. The video relates (quite literally) to the notion of ‘avalanches’ in the title of this exhibition and the film stems from a conversation that started between Steve and myself (and continues to this day) about the catastrophes that result from trying to deal with landslides of material from abandoned artistic activities which often end up strewn chaotically across the studio. Dutton and Peacock made a film called ‘Plague-Orgy-Time’ in 1997 and I first saw it in their exhibition ‘Apocatropes’ at the Mappin Gallery in the same year. I was taken by their approach to a ‘series of accretions of things in a space punctuated by scattered evidence of artistic activity’ (Glover, I. 1997). My film deals with a similar issue but in this case the studio is reduced to a model and artistic activities are miniaturised in a series of ‘Gulliver-esque’ tableaux or enactments – each one punctuated by the close of a stage curtain. In a way my film consciously tends towards 'the reproduced', the constructed stage, film or theatre set in its depictions of a series of avalanches and visually references old slapstick humour films in a sequence of ‘vignettes’. The strange beauty of this apparently absurd process experienced in the studio is foregrounded in this 'homage'. References Izi Glover 1997 ‘Musée Imaginaire’ Frieze Issue 3

R\ue9nyi entropies of generic thermodynamic macrostates in integrable systems

We study the behaviour of R\ue9nyi entropies in a generic thermodynamic macrostate of an integrable model. In the standard quench action approach to quench dynamics, the R\ue9nyi entropies may be derived from the overlaps of the initial state with Bethe eigenstates. These overlaps fix the driving term in the thermodynamic Bethe ansatz (TBA) formalism. We show that this driving term can be also reconstructed starting from the macrostate's particle densities. We then compute explicitly the stationary R\ue9nyi entropies after the quench from the dimer and the tilted N\ue9el state in XXZ spin chains. For the former state we employ the overlap TBA approach, while for the latter we reconstruct the driving terms from the macrostate. We discuss in full detail the limits that can be analytically handled and we use numerical simulations to check our results against the large time limit of the entanglement entropies