The effect of Satureja khuzestanica on triglyceride, glucose, creatinine and alkaline phosphatase activity in rat

زمینه و هدف: مرزه یا ساتوریا خوزستانیکا (Satureja khuzestanica) از گیاهان بومی ایران می باشد که به طور گسترده ای در نواحی جنوبی کشور به ویژه استان لرستان وجود دارد و در طب سنتی دارای مصارف پزشکی، از جمله فعالیت ضد درد و عفونت می باشد. در مطالعات قبلی مشاهده گردید که این گیاه باعث کاهش معنی دار وزن در موشهای مورد آزمایش شده است. بر همین اساس بر آن شدیم اثرات دم کرده و اسانس روغنی این گیاه را روی وزن بدن، دریافت غذا و فاکتورهای لیپیدی، قندی، پروتئینی، الکترولیت ها و آنزیم های کبدی در رت بررسی کنیم. روش بررسی: این مطالعه تجربی است که در سال 1382 در مرکز تحقیقات گیاهان دارویی دانشگاه علوم پزشکی لرستان انجام شد. دم کرده گیاه مزبور به مقادیر 75، 150 و 250 میلی گرم بر کیلوگرم از راه خوراکی به مدت سه هفته به ترتیب برای حیوانات در سه گروه تجویز شد و در گروه چهارم، اسانس روغنی گیاه در آب خوراکی به میزانppm 1000 حل و تجویز گردید. در عین حال برای گروه کنترل هیچگونه گیاهی تجویز نشد. وزن حیوانات و میزان دریافت آب و غذای آنها بصورت روزانه ثبت گردید و در پایان 3 هفته فاکتورهای خونی و آنزیم های کبدی در سرم این حیوانات اندازه گیری شد. داده ها با آزمون ANOVA یکطرفه و بدنبال آن آزمون Tukey با یکدیگر مقایسه گردید و در بعضی گروهها که توزیع داده ها نرمال نبود از آزمون من ویتنی استفاده شد. یافته ها: میزان تری گلیسرید سرمی در گروه اسانس روغنی )92/3±15/43 میلی گرم بر دسی لیتر) نسبت به گروه کنترل (03/8±99/89 میلی گرم بر دسی لیتر) تفاوت معنی دار داشت (001/0

A review on most important herbal and synthetic antihelmintic drugs

Parasites and parasitic diseases are widely spread in the world. Their adverse effects on health and social economic society cause tremendous public health problems. Parasitic infections in different ways (water, soil, food and vegetables) can affect humans and induce other complications such as gastrointestinal disorders, malnutrition, anemia and allergies and sometimes even life threatening. Medicinal plants are being widely used, either as a single drug or in combination with synthetic drugs. These medicinal plants are considered as a valuable source of unique natural products and drugs for development of medicines against various disorders and diseases. In this article the recently published papers about medicinal plants and parasites were reviewed, using scientific sites such as Medline, PubMed and Google Scholar. The used terms included: herbal medicine, medicinal plants, and antihelmintic drugs, antinematoda, anticestoda, antitrematoda. From the above collected literature it might be concluded that these plants are promising potential sources for preparation of new drugs or for pharmacological and therapeutic applications

Evaluation of Antibiofilm Activity of Dentol

Biofilm is a community of bacteria which are attaching to a surface. They are responsible for many of catheter related or dental plaque related infectious diseases. Different approaches have been used for preventing biofilm related infections in health care settings. Many of these methods have disadvantages such as chemical based complications, and emergent antibiotic resistant strains. Therefore antibiofilm effect of Dentol was evaluated on two important medical bacterial biofilms in this study. Methods: Minimum inhibitory concentrations (MIC) of Dentol was calculated by serial dilution method by microtiter plates against standard bacteria. Antibiofilm effect of Dentol was evaluated by microtiter plate assay and after measuring absorbance in 550 nm, the difference between groups was calculated by Cruskal-wallis and Mann-withney tests. Results: 1:80 (12.5 μl/ml) & 1:20 (50 μl/ml) dilutions of commercially available Dentol were measured as MICs for S.aureus and P.aeruginosa, respectively. Two-fold dilutions of Dentol MICs completely eradicated and inhibited biofilm formation. Statistical analysis between test groups revealed significant differences. Disscussion: Dentol is a medicinal herbal essential oil derived from Satureja khuzestanica (SKEO). Several in vitro studies have reported its antidiabetic, analgesic, anti-inflammatory, and anti-hyperlipidemic effects. So because of complications that have been encountered in health care settings from routine methods of catheter processing, and biofilm related problems, efficacy of Dentol for destruction of bacterial biofilms as a safe material was studied

Effect of Curcumin on AQP5 gene expression in HT-29 human colorectal cancer cells

Background: Colorectal carcinoma is the third most common type of cancer and the second most common cause of cancer-related mortality in the world. The aquaporins (AQPs) are water channel proteins that play a major role in water movements through epithelial and endothelial tissues. Expression of AQP5 was induced in the early stages of colon cancer. An induction of AQP5 expression in colon cancer suggests a probable driving force roles for AQP5 in colon carcinogenesis. Curcumin, as a chemopreventive phytochemical is important to block, retard or reverse the process of carcinogenesis. Several studies have suggested that curcumin may prevent or delay the occurrence of colorectal cancer. This study aimed to examine the effect of curcumin on the inhibition of AQP5. Materials and Methods: In this experimental study, the HT-29 cell line was cultured in DMEM medium containing 10 % FBS and 100 U/ml penicillin and 100 mg/ml streptomycin. The effect of curcumin concentrations on the growth of cells was determined using the MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay. Immunocytochemistry was performed to examine the effect of curcumin on the expression of AQP5. Results: Immunocytochemistry showed the decreased amount of AQP5 protein in the curcumin-treated cells. Conclusion: Curcumin inhibits the expression of AQP5 in human colorectal cancer cell line, HT-29. The inhibition of AQ5 expression may provide a novel therapeutic target for the treatment and prevention of colorectal cancer

Medicinal plants and secondary metabolites for diabetes mellitus control

Diabetes mellitus is one of the most common and complex problems of modern societies which has caused many economic and social problems. Because diabetes has no definite treatment, the use of traditional medicine seems to be an appropriate solution to control and manage it. Studies revealed that Vaccinium Arctostaphylos L., Securigera securidaca L., Gymnema sylvestre L., Atriplex halimus L., Camellia sinensis L., Ginkgo biloba L., Mamordica charantia L., Citrullus colocynthis (L.) Schrad., Allium cepa L., Allium sativum L., Silybum marianum (L.), Gaertn and Trigonella foenum graecum L. are effective against diabetes. Flavonoids, quercin, metformin, quinolizidine, anthocyanin, catechin and flavone, phenylpropanoids, lipoic acid and coumarin metabolites were introduced major impact on diabetes. With regard to the study of plants and their metabolites and the mechanisms of their influence, it is clear that these plants have the potential to reduce blood sugar and diabetes and be considered as candidates for preparing new drugs. Combination of plants extracts or their components may also have synergistic effects to better act on diabetes. © 2014 Asian Pacific Tropical Medicine Press

Ethnobotanical identification of medicinal plants effective on bloat in Lorestan province, West of Iran

Objective: Bloating and gas accumulation is one of the most common gastrointestinal disorders. Since herbs are always on of the most important source of medicines for many kind of diseases, so we try to investigate and introduce Lorestan local anti-bloating herbs in this study. Methods: The traditional treatment data of this study were collected from the indigenous peoples and through cooperation of Dorud Health and treatment Network, Boroojerd, Khorramabad, Aleshtar, Poldokhtar, Aligudarz, Nurabad and Kouhdasht. Questionnaires were prepared before and the volunteers were trained. Trained volunteers by mentioned questionnaire recorded people's beliefs about alternative medicine in the treatment of flatulence. Results: Eventually it was investigated that 13 remedial plants from 10 plant families were effective in the treatment of flatulence. In many parts of the world, especially in remote areas where there isn't any access to doctors and medicine, people use Folk medicine and homemade treatments. Conclusions: The awareness of these applications can be a policy for the achievement of new medicinal uses of these plants which hadn't been reported in the available literature as well. Ethnobotanical identification of medicinal plants effective on bloat in Lorestan province, West of Iran. Available from: https://www.researchgate.net/publication/297372118_Ethnobotanical_identification_of_medicinal_plants_effective_on_bloat_in_Lorestan_province_West_of_Iran [accessed Jul 26, 2017]

Ethnobotany study of effective medicinal plants on gastric problems in Lorestan province, West of Iran

Digestive disorders are included high proportion and prevalent of human diseases. Most of these diseases occur as gastric and duodenal peptic ulcer, gastritis and dyspepsia. Treatment of disorders and diseases particularly gastritis and peptic ulcers have been done with medicinal plants in Lorestan province located in west of Iran. The aim of this study was to identify medicinal plants in this area which have been used to treat stomachache, gastritis and peptic ulcers. Obtained results from the questionnaire showed that 15 species of medicinal plants of eleven families are used for treatment of stomach disorders, including gastritis and peptic ulcers. Laminaceae family has the greatest therapeutic effect on gastritis and peptic ulcers. Leaves were the most used organs (31) in 15 medicinal plants. Given to high incidence of digestive disorders in different societies and due to novelty of medicinal information of this study and their bioactive and antioxidants substances, medicinal plants can be used to produce natural products to treat gastric disorders. © 2015, Journal of Chemical and Pharmaceutical Research. All rights reserved

An ethnobotanical study of medicinal plants used in treatment of kidney stones and kidney pain in Lorestan province, Iran

Kidney stones are the third most frequent disorder of the urinary tract, after infections and pathological disorders of the prostate. Most affected patients suffer from severe colicky pain. The use of herbs for treating diseases has been a common method since ancient times. This study aimed to identify and report the most important and effective herbs for treating kidney stones and kidney pain in Lorestan province (west of Iran). We accomplished our goal by gathering and integrating indigenous data from local inhabitants of Lorestan. Data were gathered with cooperation of the agents of public health service network all over the towns of Dorud, Boroujerd, Khorramabad, Aleshtar, Poledokhtar, Aligoodarz, Nurabad and Kouhdasht. Prepared questionnaires were distributed to the health system trained volunteers. These trained inquirers attended in villages and recorded the local herbal therapy methods and information. Finally, 17 plants from 12 families were identified. Besides predicating the traditionally believed effects of these herbs, it is essential for researchers to find out the actuality of their clinical effectiveness and active substances. Once the positive effects of these herbs were proved to be true, it is possible to produce drugs which are useful in treatment and controlling kidney stones and pain