12 research outputs found
Shared decision-making experiences in child long-term ventilation : a systematic review
- Publication venue
- Publication date
- 30/09/2023
- Field of study
INTRODUCTION: Recent decades have seen an increase in children receiving long-term ventilation. To ensure that long-term ventilation decisions incorporate the perspectives of stakeholders, it is vital that empirical evidence is gathered to substantiate frameworks and guidance on shared decision-making for long-term ventilation. This systematic review and qualitative evidence synthesis aimed to clarify what shared decision-making constitutes in relation to long-term ventilation initiation for children and young people (<21 years). METHODS: A systematic review of qualitative research was undertaken. Searches were conducted in MEDLINE, Embase, CINAHL, PsycINFO and Web of Science. RESULTS: Findings from 13 studies were included representative of 363 caregivers and 143 healthcare professional experiences. Components that support shared decision-making included acknowledging the unique positionality of caregivers and ensuring caregivers were informed about the implications of long-term ventilation. Beneficial qualities of engagement between stakeholders included honest, clear and timely dialogue using lay, tactful and sensitive language. CONCLUSION: Our findings clarify components and approaches supportive of shared decision-making in discussions about long-term ventilation. This review therefore provides a valuable resource to implement shared decision-making practices in the context of long-term ventilation decisions for children and young people
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
- Author
- Antoun Elie
- Cerundolo Lucia
- Cespedes Pablo F
- Chen Ji-Li
- Chen Yi-Ling
- Ciaoca Raul
- Clark Kevin
- Clark Sally-Ann
- Dominey-Foy Delaney CC
- Dong Tao
- Draganov Simeon D
- Dustin Michael L
- Fernandes Ricardo A
- Fisher Roman
- Gao Fei
- Gileadi Uzi
- Hamid Megat HBA
- Hester Svenja S
- Jin Chen
- Kanellakis Nikolaos
- Kessler Benedikt M
- Khalid-Alham Nasullah
- Kvalvaag Audun
- Liang Zhu
- Liu Guihai
- Maldonado-Perez David
- Manoharan Nikita
- Nanayakkara Charunya
- Ogg Graham
- Peng Yanchun
- Pinto-Fernández Adán
- Rahman Najib M
- Sopp Paul
- Teague Renuka
- Vendrell Iolanda
- Verrill Clare
- Waugh Craig
- Yao Xuan
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been associated with better clinical prognosis in patients with cancer. However, the specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear. Here, we show an unexpected and transient CD61 expression, which is paired with CD103 at the synaptic microclusters of T cells. CD61 colocalization with the T cell antigen receptor further modulates downstream T cell antigen receptor signaling, improving antitumor cytotoxicity and promoting physiological control of tumor growth. Clinically, the presence of CD61+ tumor-infiltrating T lymphocytes is associated with improved clinical outcomes, mediated through enhanced effector functions and phenotype with limited evidence of cellular exhaustion. In conclusion, this study identified an unconventional and transient CD61 expression and pairing with CD103 on human immune cells, which potentiates a new target for immune-based cellular therapies
Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants
- Author
- Adams Sally S.
- Adams-Chapman Ira
- Alexander Barbara
- Alksninis Barbara
- Ambalavanan Namasivayam
- Anderson Jack M.
- Appel Diana D.
- Arnell Kathy
- Bada Henrietta S.
- Bailey Kirstin J.
- Ball M. Bethany
- Bara Rebecca
- Baran Joan M.
- Bartick Melissa C.
- Bauer Charles R.
- Bell Edward F.
- Biasini Fred J.
- Bogen Debra L.
- Bohnke Lon G.
- Broyles R. Sue
- Calejo Maria
- Carlo Waldemar A.
- Carter Sheena
- Chopko Stephanie A.
- Close Nancy
- Colaizy Tarah T.
- Colaizy Tarah T.
- Collins Monica V.
- Cosby Shirley S.
- Das Abhik
- Delaney-Black Virginia
- Demetrio Clarence
- Diaz Alexis N.
- Donovan Edward F.
- Dooley Cristin
- Duara Shahnaz
- Dusick Anna M.
- Eaken Greg
- Ehrenkranz Richard A.
- Everett-Thomas Ruth
- Fanaroff Avroy A.
- Finer Neil N.
- Frade Silvia M.
- Friedman Harriet G.
- Fuller Martha G.
- Gettner Patricia
- Gideon Yamiley
- Gilliam Walter S.
- Goldston Laura A.
- Gratton Teresa L.
- Green Brittany D.
- Grisby Cathy
- Guzman Alicia
- Hale Ellen C.
- Hamlin-Smith Kasey
- Hastings Betty K.
- Henderson Christopher
- Hensman Angelita M.
- Herron Dianne E.
- Hessling Jody
- Heyne Elizabeth T.
- Hickman Jackie F.
- Higgins Rosemary D.
- Hintz Susan R.
- Hiriart-Fajardo Silvia
- Hudson Tina
- Jean-Gilles Lisa
- Jegier Briana J.
- Jobe Alan H.
- Johnson Yvette R.
- Kardatzke Darlene
- Kennedy Deborah
- Kohn Jean G.
- Konstantino Monica
- Korones Sheldon B.
- Laptook Abbot R.
- LaRossa Maureen Mulligan
- Leach Teresa M.
- Lee-Ancajas Julie C.
- Lemons James A.
- Leonard Martha R.
- Lytle Carolyn
- Madden Linda A.
- Madison Susie
- Mathews Elaine O.
- McClure Elizabeth M.
- McClure Elizabeth M.
- Mersmann Marcia Worley
- Miller Lucy C.
- Mincey Holly L.
- Muran Geraldine
- Nelson Kathleen G.
- Newman Nancy S.
- Noel Lucy
- O'Donnell Auman Jeanette
- Oh William
- Peralta-Carcelen Myriam
- Phillips Vivien A.
- Poindexter Brenda B.
- Poole W. Kenneth
- Posin Donna
- Poulsen JoAnn
- Rasmussen Maynard R.
- Rector Richard V.
- Reinhold Arnold G.
- Richard Leslie
- Romano Elaine
- Salhab Walid A.
- Schaefer Andrew J.
- Schibler Kurt
- Schwarz Eleanor Bimla
- Shankaran Seetha
- Siner Bonnie S.
- St. John Nicholas H.
- Steichen Jean J.
- Stevenson David K.
- Stoll Barbara J.
- Stuebe Alison M.
- Taylor Sarah
- Vaucher Yvonne E.
- Vohr Betty R.
- Walden Rachel V.
- Walsh Michele C.
- Watson Victoria E.
- Williams Marilyn G.
- Wilson Leslie Dawn
- Wilson-Costello Deanne E.
- Worth Amy Mur
- Wrage Lisa Ann
- Wright Linda L.
- Yolton Kimberly
- Publication venue
- Publication date
- 01/01/2016
- Field of study
To estimate risk of NEC for ELBW infants as a function of preterm formula and maternal milk (MM) intake and calculate the impact of suboptimal feeding on NEC incidence and costs
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-Hélène
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ève
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Érin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-Chénard Émilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- Cárcel Sheila
- Côté Émilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Ellis Yvette
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelman¸ Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazla Fathima
- Featherstone Peter
- Felton Tim
- Fennessy Gerard
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernandes Edna
- Fernandez Maria
- Fernando Gloria
- Fernández de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
- Finn André
- Finn Stephanie
- Finnis Mackenzie
- Fiouni Sofia
- Fischer Roy
- Fitzgerald Mark
- Fitzpatrick Meghan
- Fletcher Simon
- Flint Neil
- Flor Thomas
- Florescu Simin
- Fluher Jure
- Flynn Gordon
- Focà Emanuele
- Folci Marco
- Forbes Andrew
- Ford Megan
- Forster Elliot
- Foster Tracy
- Fottrell-Gould Deirdre
- Foulds Angela
- Fowler Rob
- Fowler Robert
- Fox Claire
- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
- Francois Bruno
- Frankfurter Claudia
- Franz Christopher
- François Bourgerol
- Fraser Catherine
- Frater Alasdair
- French Craig
- Frey Anna
- Frey Christian
- Frise Matthew
- Frost Victoria
- Fuchs Ralph
- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
- Ganguly Saibal
- Garcia Sara
- Gardiner-Hill Caroline
- Garot Denis
- Garrard Hywel
- Garrard William
- Garrett Peter
- Garrier Ludivine
- Garrod Esther
- Garton Mark
- Garvey James
- Gascoyne Rachel
- Gattas David
- Gauli Basanta
- Gay Alexandra
- Gaylard Jane
- Gellamucho Minerva
- Gemmell Lisa
- Gendall Emma
- Geng Wenli
- Geoghegan Pierce
- Geri Guillaume
- Geurts Heidi
- Ghaffari Mehrdad
- Ghamraoui Ali
- Ghattaoraya Amardeep
- Ghosh Alison
- Giardina Giuseppe
- Gibbins Alexandra
- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
- Girard Timothy
- Girijadevi Dinuraj
- Gladas Kirsty
- Glasby Kathleen
- Gledhill Lisa
- Glister Georgina
- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
- Graham Libby
- Graniewski Jaroslaw
- Grant Caroline
- GrauNovellas Neus
- Greco Massimiliano
- Grecu Irina
- Green Cameron
- Green Jackie
- Greene Emma
- Greener Danni
- Gregory Jane
- Gresham Rebecca
- Greven Frances
- Grieve Richard
- Grimm Patrick
- Grimmer Lisa
- Groeneveld Erika
- Gross Jamie
- Grünewaldt Achim
- Guanco Mark
- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
- Gupta Abhinav
- Gurung Anita
- Guérin Emmanuelle
- Gómez Francisco
- Göpel Siri
- Habeichi Wadih
- Habraken Hannah
- Hadebe Bernard
- Haffiane Abdelmagid
- Hagel Stefan
- Haghi Theerata
- Haiba Khalid
- Haidar Ghady
- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
- Hanisch Alexis
- Hanley Joanne
- Hansen Dan
- Hanson Helen
- Hanson Jane
- Harden Lesley
- Harding Daniel
- Hardy Chloe
- Harford Rachel
- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
- Hassan Noor
- Hausermann Marie-Helene
- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
- Hayes Leanne
- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
- Henning Jeremy
- Henri-Lagarrigue Matthieu
- Henry Joanne
- Henry Lavinia
- Hensley Joseph
- Heritier Stephane
- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
- Hoiting Oscar
- Holbrook Catherine
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- Oza Deepali
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
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- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
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- Udayanga Ishara
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- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
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- van den Berg Lettie
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- van der Eng Hetty
- Van Der Heyden Kymbalee
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- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
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- Vieillard-Baron Antoine
- Vignesh C
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- Vilá Clara
- Vincent Rachel
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- Visentin Elisa
- Visser Yorik
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- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
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- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
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- Wigbers Jeanette
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- Wilcox Louise
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- Wilding Laura
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- Willams Felicity
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- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
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- Albert Mélanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
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- Ali Abraham
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- Ali Mohamed Ahmed
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- Ige F.A.
- Iguosadolo Nosamiefan
- Ihazmad Hassan
- Ihekweazu Chikwe
- Iknane A.A.
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- JOEL Ireoluwa Yinka
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- Tan M.
- Tan Michelle
- Tarnagda Zekiba
- Tarupiwa Andrew
- Tatfeng Mirabeau Y.
- Tato C.
- Tato Cristina M.
- Taweh Fahn M.
- Tayachew Adamu
- Tayimetha Carolle Yanique
- Taylor Susan
- Tchibozo Carine
- Tchoudjin Herve Christian Paho
- Tebeje Yenew K.
- Tefelo Thela
- Tefera D.A.
- Tefera Dessalegn Abeje
- Tegally Houriiyah
- Tegomoh Bryan
- Tegueni Kokou
- Tei-Maya
- Teka Gizaw
- Tembo John
- Tesfaye Abraham
- Tesfaye Gelanew
- Tesfaye Kassahun
- Tessema Sofonias K.
- Testimony Olumade
- Thiam Aminata Sileymane
- Thilliez Gaetan
- Thiongo K.
- Thomas Van L.
- Tia Alie
- Tinto Halidou
- Tollera Getachew
- Tombolomako T. B.
- Tomkins-Tinch C.
- Tomori Oyewale
- Tongo Marcel
- Top Ndeye Marieme
- Tordo Noël
- Toure Abdoulaye
- Touré Bamba Fatoumata
- Touzani Charifa Drissi
- Touzani Otmane
- Trabelsi Sameh
- Traoré
- Traoré Adjaratou
- Treurnicht Florette
- Triki H.
- Triki Henda
- Trotter Alexander J.
- Tsegay Yao
- Tshiabuila Derek
- Tsiry R.
- Tsofa Benjamin
- Tuki Keyru
- Tumedi Kefentse A.
- Turki M.
- Tushabe Phionah
- Tuyisenge Patrick
- Tyers Lynn
- Uche Peace O.
- Ugwu C.A.
- Ulrich M.
- Umumararungu Esperance
- Umuringa Jeanne d’Arc
- Upton Arlo
- Ushijima Yuri
- Ussher James
- Utpatel Christian
- Uwanibe Jessica N.
- Uwituze Arlene
- van der Eijk Annemiek
- van der Linden Anne
- van der Linden Antje
- van der Werf Sylvie
- Van Rooyen G.
- van Rooyen Gerhard
- van Wyk Stephanie
- van Zyl Gert U.
- Vanaerschot M.
- Vanmechelen Bert
- Vanpeene Maud
- Velavan Thirumalaisamy P.
- Venter Marietjie
- Vernet Marie-Astrid
- Viana R.
- Vickos U.
- Victoir Kathleen
- Vida Ahyong
- Vidal Nicole
- Viegas Sofia
- Vincent Grace
- Vinze Anika
- Voegtly Logan J.
- von Gottberg Anne
- Waberi Zeinab Ali
- Wadi Amira Suliaman
- Wadonda N.
- Wadula J.
- Wagner Philipp
- Wahab Kolawole Wasiu
- Waitumbi John
- Walter Mathias C.
- Wamala Joseph F.
- Wandera Dennis N.
- Wang Jing
- Wang Xiuhua
- Wani Gregory
- Wanjohi Dorcas W.
- Wanok Stephen
- Waruhiu C.N.
- Waruhiu Cecilia
- Wasfi Fares
- Watters Chaselynn M.
- Wawina-Bokalanga Tony
- Wayengera Misaki
- Wayoro Oby
- Webby R.
- Webby Richard
- Weldemariam A.G.
- Weldemariam Atsbeha G.
- Werno Anja
- Wiley Michael R.
- Wilkinson David
- Wilkinson Eduan
- Williamson Carolyn
- Wilson Shannon
- Woelfel R.
- Wohl Shirlee
- Wolh S.
- Wolter Nicole
- Wuduri Zara
- Wulf Ben
- Wurie I.
- Wurie Isatta
- Xavier Joicymara S.
- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Development of a methodology for monitoring spinal neuroinflammation mechanisms in the neuropathic rat in vivo
- Author
- Publication venue
- Publication date
- 01/07/2010
- Field of study
Spinal release of pro-inflammatory cytokines plays a pivotal role in the aberrant neuronal signalling that underlies neuropathic pain. This thesis sought to develop a methodology for monitoring spinal cytokine release in vivo using ‘high flux’ microdialysis sampling. In vitro studies characterising ‘high flux’ membranes Plasmaflo® (Poly-E), Prisma® (Poly-P), Terumo®(CUP-R) and commercially available probe, CMA/20 (nominal cut-off 3000,≈3000, 60 and 100 kDa respectively) revealed that Poly-E and Poly-P were significantly better in recovering IL-1β than the commercially available probe (58, 48 and 38% at 0.5 µl/min, n=4-5, respectively). Poly-E was identified as the most suitable membrane for in vivo studies. For future in vivo studies, disinfection of the membrane and blockade of non-specific peptide binding sites by siliconisation rather than conventional use of BSA, was shown not to adversely affect the dialysing capability of the Poly-E membrane. In rats with CCI-induced mechanical hypersensitivity intrathecal microdialysis was successful in measuring basal levels of IL-1β, IL-6 and TNFα (68±27, 5714±2451 and 638±175 pg/ml (mean ± SEM, n=10) respectively). Electrical stimulation capable of activating C-fibres was shown to induce IL-1β (≈ 3-fold), but not IL-6 and TNFα release in CCI animals compared to sham controls. In further studies, intrathecal microdialysis sampling was successfully performed in freely moving naïve animals. Atlanto-occipital catheterisation however, was associated with welfare concerns so a less invasive lumbar catheterisation technique was evaluated. This technique was well tolerated and may prove valuable in determining the spinal cytokine release in animal pain models
The 12q14 microdeletion syndrome: six new cases confirming the role of HMGA2 in growth
- Author
- Amanda L Collins
- Ann-Charlotte Thuresson
- B Menten
- Bernt-Oves Hedberg
- BH LaMonte
- Carol A Delaney
- Caroline M Murray
- Colm Costigan
- David R Fitzpatrick
- F Mari
- Freddie Sharkey
- Göran Annerén
- J Hellemans
- James Iremonger
- John A Crolla
- K Buysse
- M Fichera
- Nicola Foulds
- Regina Regan
- RF Stern
- S Spengler
- Sally Ann Lynch
- SB Jurenka
- Sean Ennis
- SS Chong
- TD Schmittgen
- Wayne Lam
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
We report six patients with array deletions encompassing 12q14. Out of a total of 2538 array investigations carried out on children with developmental delay and dysmorphism in three diagnostic testing centres, six positive cases yielded a frequency of 1 in 423 for this deletion syndrome. The deleted region in each of the six cases overlaps significantly with previously reported cases with microdeletions of this region. The chromosomal range of the deletions extends from 12q13.3q15. In the current study, we report overlapping deletions of variable extent and size but primarily comprising chromosomal bands 12q13.3q14.1. Four of the six deletions were confirmed as de novo events. Two cases had deletions that included HMGA2, and both children had significant short stature. Neither case had osteopoikilosis despite both being deleted for LEMD3. Four cases had deletions that ended proximal to HMGA2 and all of these had much better growth. Five cases had congenital heart defects, including two with atrial septal defects, one each with pulmonary stenosis, sub-aortic stenosis and a patent ductus. Four cases had moderate delay, two had severe developmental delay and a further two had a diagnosis of autism. All six cases had significant speech delay with subtle facial dysmorphism.<br/
Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants
- Author
- Abbot R. Laptook
- Abhik Das
- Alan H. Jobe
- Alexis N. Diaz
- Alicia Guzman
- Alison M. Stuebe
- Amy Mur Worth
- Andrew J. Schaefer
- Angelita M. Hensman
- Anna M. Dusick
- Arnold G. Reinhold
- Avroy A. Fanaroff
- Barbara Alexander
- Barbara Alksninis
- Barbara J. Stoll
- Bartick
- Bartick
- Betty K. Hastings
- Betty R. Vohr
- Bigger
- Bisquera
- Bonnie S. Siner
- Brenda B. Poindexter
- Briana J. Jegier
- Brittany D. Green
- Callen
- Callen
- Carolyn Lytle
- Cathy Grisby
- Charles R. Bauer
- Christopher Henderson
- Clarence Demetrio
- Colaizy
- Cristin Dooley
- Cristofalo
- Darlene Kardatzke
- David K. Stevenson
- Deanne E. Wilson-Costello
- Deborah Kennedy
- Debra L. Bogen
- Diana D. Appel
- Dianne E. Herron
- Donna Posin
- Edward F. Bell
- Edward F. Donovan
- Elaine O. Mathews
- Elaine Romano
- Eleanor Bimla Schwarz
- Elizabeth M. McClure
- Elizabeth M. McClure
- Elizabeth T. Heyne
- Ellen C. Hale
- Fitzgibbons
- Forray
- Fred J. Biasini
- Ganapathy
- Geraldine Muran
- Greg Eaken
- Guillet
- Guthrie
- Hair
- Hake-Brooks
- Harriet G. Friedman
- Heiman
- Henrietta S. Bada
- Heron
- Hirth
- Holly L. Mincey
- Hull
- Ira Adams-Chapman
- Jack M. Anderson
- Jackie F. Hickman
- James A. Lemons
- Jean G. Kohn
- Jean J. Steichen
- Jeanette O'Donnell Auman
- Jegier
- Joan M. Baran
- JoAnn Poulsen
- Jody Hessling
- Johnson
- Johnson
- Johnson
- Julie C. Lee-Ancajas
- Kasey Hamlin-Smith
- Kathleen G. Nelson
- Kathy Arnell
- Kimberly Yolton
- Kirstin J. Bailey
- Kung
- Kurt Schibler
- Laura A. Goldston
- Leslie Dawn Wilson
- Leslie Richard
- Linda A. Madden
- Linda L. Wright
- Lisa Ann Wrage
- Lisa Jean-Gilles
- Llanos
- Lon G. Bohnke
- Lucas
- Lucy C. Miller
- Lucy Noel
- M. Bethany Ball
- Maayan-Metzger
- Marcia Worley Mersmann
- Maria Calejo
- Marilyn G. Williams
- Martha G. Fuller
- Martha R. Leonard
- Mathews
- Maureen Mulligan LaRossa
- Maynard R. Rasmussen
- Meier
- Meier
- Meinzen-Derr
- Melissa C. Bartick
- Michele C. Walsh
- Monica Konstantino
- Monica V. Collins
- Myriam Peralta-Carcelen
- Namasivayam Ambalavanan
- Nancy Close
- Nancy S. Newman
- Neifert
- Neil N. Finer
- Nicholas H. St. John
- Patel
- Patricia Gettner
- Poindexter
- R. Sue Broyles
- Rachel V. Walden
- Rebecca Bara
- Richard A. Ehrenkranz
- Richard V. Rector
- Rosemary D. Higgins
- Ruth Everett-Thomas
- Sally S. Adams
- Sarah Taylor
- Schanler
- Schanler
- Seetha Shankaran
- Shahnaz Duara
- Sheena Carter
- Sheldon B. Korones
- Shirley S. Cosby
- Silvia Hiriart-Fajardo
- Silvia M. Frade
- Sisk
- Stephanie A. Chopko
- Sullivan
- Susan R. Hintz
- Susie Madison
- Tarah T. Colaizy
- Tarah T. Colaizy
- Teresa L. Gratton
- Teresa M. Leach
- Tina Hudson
- Tzialla
- Victoria E. Watson
- Virginia Delaney-Black
- Vivien A. Phillips
- Vohr
- W. Kenneth Poole
- Waldemar A. Carlo
- Walid A. Salhab
- Walter S. Gilliam
- William Oh
- Yamiley Gideon
- Yee
- Yvette R. Johnson
- Yvonne E. Vaucher
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
To estimate risk of NEC for ELBW infants as a function of preterm formula and maternal milk (MM) intake and calculate the impact of suboptimal feeding on NEC incidence and costs
Law in a Shrinking World: The Interaction of Science and Technology with International Law
- Author
- &
- &
- &
- &
- A V Leont&apos
- A. Belden Fields &
- Aaron Schwabach
- Adam Berkoff
- Albert Utton
- Albert Utton
- Aldo Chircop
- Alexandre Timoshenko
- Alfred Aman
- Alfred Verdross
- Allan Hutchinson
- Allott
- Allott
- Allott
- Allott
- Amedeo Postiglione
- Amy Knoll
- Andrea Seielstad
- Andreas Hamfelt
- Andy Johnson-Laird
- Ann Rodgers &
- Anthony D&apos
- Archeology Foucault
- Arthur Goodhart
- Ashley Lipson
- B
- B G Ramcharan
- Babak Nikravesh
- Barry Friedman
- Bashir Hussain
- Benjamin Barber
- Benjamin Kahn
- Bernard Hibbits
- Bernard Oxman
- Berthold Ullman
- Beverly Tarpley
- Blum
- Borders In Cyberspace
- Boyle
- Brian Tamanaha
- Brij Chauhan
- Bruce Bimber
- Bruce Rich
- Bryan Walser
- Bryan Wildenthal
- C O Okidi
- Caldwell
- Carlos Wing-Hung Lo
- Carol Jones
- Carole Rose
- Catherine Richmond
- Catherine Tinker
- Cavazos &
- Charles Pierce
- Chen
- Chin Kim
- Christopher Joyner
- Christopher Lasch
- Clive Walker
- Colin Mccarthy
- Colum L Rev
- Comparative
- Constitutionalizing Daniel Elazar
- Context Text
- Contract See Generally
- Craig Murphy
- Creighton L
- Cyrus Tata
- Dan Burk
- Dan Burk
- Daniel Barstow
- Daniel Kennedy
- Daniel Murphy
- Daniel Rose
- Daniel Tarullo
- Daniel Turack
- Danilenko
- David Caron
- David Hunter
- David Jabbari
- David Johnson
- David Johnson &
- David Johnson &
- David Johnson &
- David Kennedy
- David Martin
- David Rier
- David Scheffer
- David See Generally
- De Lupis
- Dennis Arrow
- Derek Asiedu-Akrofi
- Dinah Shelton
- Ding Xueliang
- Domestic Law Reforms In Post-Mao China
- Dominique Alheritiere
- Donald Hornstein
- Douglas Hayes
- Douglas Johnston
- Douglas Lee Donoho
- Douglas Litowitz
- Douglas Sanders
- E D Krol
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- Econ Organization For
- Edward Mcwhinney
- Elaine Chaney
- Elisabeth Rosehthal
- Ellen Hey
- Erik Eckholm
- Ernest Smerdon
- Ernst Haas
- Eugene Volokh
- Eugene Volokh
- F V Garcia-Amador
- Frances Cairncross
- Francis Boyle
- Francis Gilligan
- Frank Andrews
- Frank Emmert
- Frank Michelman
- Frank Newman &
- Fran�ois Mathys
- Fred Heller
- Frederic Jameson
- Frederick Schauer
- Fredric Lederer
- Friedrich Kratochwil
- From Martti Koskenniemi
- G A Res
- G Burgess Allison
- G Edward White
- G Sartor &
- G Webb
- Gamble
- Gamble
- Geo L Int&apos
- George Field
- George Landow
- Georges Kaeckenbeeck
- Georgio Bosco
- Gilligan &
- Graefrath
- Graham Greenleaf
- Gray Mark Allan
- Gregg Vetter
- Gregory Joseph
- Gregory Maggs
- Guenther Teubner
- H W A Thirlway
- Hank Johnston &
- Harold Berman
- Harold Bordwin
- Harold See
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- Harry Collins &
- Harv J Int&apos
- Harv L Rev
- Henry Perritt
- Henry Perritt
- Henry Perritt
- Herbert Smith
- Hersch Lauterpacht
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- I
- I
- I Trotter Hardy
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- I Trotter Hardy
- Ian Johnstone
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- Id
- Int&apos
- Int&apos
- Irvin Molotsky
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- J
- J C Smith
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- J Int&apos
- Jack Brown
- Jack Goldsmith
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- Jacques Derrida
- James Boyle
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- James Keane
- Jane Ginsburg
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- Janis
- Janusz Symonides
- Jason Mark Anderman
- Jay Carlisle
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- Jay Erstling
- Jean-Fran�ois Lyotard
- Jeff Trask
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- M Ethan Katsh
- M Ethan Katsh
- Maclean
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- Marc Lauritsen
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- Marshall Mcluhan
- Marta Haines-Ferrari
- Martha Minow
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- Marxism Symposium
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- Max Weber
- Mcdonough
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- Michael Ciresi &
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- Michael Kennedy
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- Morgan Cloud
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- Myres Mcdougal
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- Oedel
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- Phillip Trimble
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- Pierre-Marie Dupuy
- Preserving The
- R A W Rhodes
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- R P Dhokala
- R R Baxter
- R S Gupta
- Ralph Taylor
- Raphael Winick
- Raymond Bonner
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- Rebecca Leigh
- Reinhard Bendix
- Rev Marshall L
- Richard Baxter
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- Richard Dunn
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- Richard Ryan Lamb
- Robert Dunne
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- Robert Houseman
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- Roger Cohen
- Roger Meyers
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- Ronald &
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- Russian
- Sally Merry
- Samuel Guiberson
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- See Also Ray Jay Davis
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- Social Roberto Unger
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- T C Hartley
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- Towards
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- Trask
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- Uri Schild
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- Yao Meizhen
- Yvonne Tharpes
- Zaure Ayupova
- Zhou Dadi
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2000
- Field of study
Empagliflozin in Patients with Chronic Kidney Disease
- Author
- Aamir Navivala
- Abdulwahab Arbi
- Abegail Hernandez Pena
- Abraham Hanburry
- Adedolapo Adeleke
- Adeera Levin
- Adil Hazara
- Adline Ghazi
- Agnes Masengu
- Ahmad Tuffaha
- Ahmed Awad
- Ahmed Ghanem
- Ai Fukasawa
- Aik Kheng Lee
- Aiko Terakawa
- Aiko Tomita
- Aiko Yamada
- Ailsa Geddes
- Airi Sato
- Akane Katanosaka
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- Pauline Swift
- Peiling Chen
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- Rocco Baccaro
- Rodel Gloria
- Rodolfo Rivera
- Roger DeRaad
- Roland Veelken
- Ronald Goldenberg
- Rosalyn Wheatley
- Rosario Machicado
- Rosemarie Henschel
- Rossello Xavier
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- Rotimi Oluyombo
- Rowan McDougall
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- Rupal Mehta
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- Sarasa Ramasamy
- Sarojini Sivanandam
- Sasha Dorestin
- Satoko Horikawa
- Satoshi Mano
- Satoshi Masumoto
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- Sawako Kato
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- Sayaka Kawashima
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- Scarlett Forest
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- Sebastian Gabel
- Seiji Itano
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- Sendogan Aker
- Sergio Rovner
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- Severin Schricker
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- Shivinder Jolly
- Shizuka Higashi
- Shogo Banno
- Shogo Kimura
- Shoichi Maruyama
- Shoji Saito
- Shoko Hayashi
- Shoko Otomo
- Shona Murray
- Shota Hashimoto
- Shraddha Shah
- Shuai Tang
- Shuang Xia
- Shuhan Zhou
- Shunichiro Asahara
- Shunsuke Goto
- Shweta Bansal
- Sian Griffin
- Sibylle J Hauske
- Silke Markau
- Simona Barberi
- Simona Bianco
- Simone Boedecker
- Simone Hagge
- Simone Streitenberger
- Simone Vettoretti
- Sina Rolfsmeier
- Sion Roy
- Siti Munirah Jaafar
- Siti Nabilah Mohamad Zaini
- Smeeta Sinha
- Smita Gunda
- Sodai Kubota
- Sofia Dayi
- Sonja Grotjahn
- Sonoka Yamamoto
- Soo Kun Lim
- Soon Yi Sor
- Sorcha Mulligan
- Sri Yarlagadda
- Sridhar Ramanaidu
- Srinivasan Beddhu
- Stacey-Ann Villaruel
- Stacie Hitchcock
- Stacy Gillham
- Staplin Natalie
- Stefan Degenhardt
- Stefan Haack
- Stefan Hantel
- Stefanie Jones
- Stefanie Kuhn
- Stephan Matthias
- Stephanie Bolton
- Stephanie Estcourt
- Stephanie Evans
- Stephanie Martinez
- Stephanie Rosenberg
- Stephanie Watson
- Stephanie Whittaker
- Stephany Topping
- Stephen Aronoff
- Steubl Dominik
- Steven Nagelberg
- Stevens Will
- Stewart Moffat
- Subash Somalanka
- Subha Clarke
- Subrata Debnath
- Sucharit Joshi
- Sue Ann Lee
- Sue Hewins
- SueAnn Squyres
- Sui Phin Kon
- Sunil Bhandari
- Sunita Bavanandan
- Suresh Ramadoss
- Suria Junus
- Susan Haskett
- Susan Hurley
- Susan McLaughlin
- Susannah Pajak
- Susanne Bodine
- Susanne Brenner
- Susumu Nakatani
- Suzannah Dorey
- Sybille Merscher
- Tabbatha Duck
- Tabinda Dugal
- Tadahiro Tomita
- Taeko Uchida
- Tai Meng Chen
- Takahiro Ishikawa
- Takahiro Kato
- Takahiro Matsunaga
- Takahiro Yamano
- Takako Kuramae
- Takako Ozawa
- Takanori Hyo
- Takashi Funayama
- Takashi Kadowaki
- Takashi Kobayashi
- Takashi Udagawa
- Takatoshi Otani
- Takayuki Katsuno
- Takehiko Wada
- Takehiro Sugiyama
- Takeshi Kurose
- Takeshi Miyatsuka
- Takeshi Ogihara
- Takuji Ishimoto
- Takuma Kojo
- Takuya Haraguchi
- Takuya Yokoyama
- Tamaki Sasaki
- Tamara Isakova
- Tammi Glider
- Tammy Ross
- Tanaji Dasgupta
- Taneera Ghate
- Taniya Nimbkar
- Tanvi Talsania
- Tara Johnson
- Tasuku Nagasawa
- Tatsuhito Himeno
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- Tejas Patel
- Teresa Kozlowski
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- Terri Chant
- Tetsuya Hosooka
- Tetsuya Shigehara
- Thahir Abdul-Samad
- The EMPA-KIDNEY Collaborative Group: Colin Baigent
- Theresa McCarthy
- Thiemo Pfab
- Thisun Saram
- Thomas Arnold
- Thomas Jones
- Thomas Phillips
- Thomas Pickett
- Thomas Sitter
- Thomas Walters
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- Timothy Ellam
- Tina Harding
- Tina Ramsey
- Ting Meng
- Tingting Kan
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- Toluleyi Sobande
- Tomoe Sato
- Tomohide Hayami
- Tomohito Gohda
- Tomohito Izumi
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- Tomoki Kosugi
- Tomoko Hisatake
- Tomoko Morisaki
- Tomoko Takahashi
- Tomoko Takai
- Tomonori Hasegawa
- Tomoya Mita
- Torsten Schramm
- Toru Ikeda
- Toshiki Kano
- Toshimasa Yamauchi
- Toshiya Yamamoto
- Toshiyuki Komiya
- Toyoyoshi Uchida
- Tracey Cummins
- Tracy Fuller
- Tracy Spinola
- Trevor Greene
- Tricia Young
- Tristan Daniels
- Tsukasa Iwakura
- Tuttle Katherine R
- Tze Jian Ng
- Ulla Ludwig
- Ulrike Giebeln-Hudnell
- Ulrike Schmidt
- Urs Benck
- Ursula Hohenstatt
- Usah Lilavivat
- Vahid Mahabadi
- Vanessa Rivers
- Verlaine Stewart-Ray
- Veronica Poma
- Veronica Yousif
- Vesta Lai
- Vicki Adell
- Vicki Brindle
- Vicki Dodds
- Vicki Donley
- Vickie Jones
- Victoria Carnall
- Victoria Gonce
- Vimal Derebail
- Vinay Varad
- Vittorio Ortalda
- Vivian Yiu
- Vladimir Cejka
- Volker Schettler
- Volker Vielhauer
- Wael Eid
- Wagdy Basily
- Wakako Isari
- Wallendszus Karl
- Waltraud Kmietschak
- Wan Ahmad Faizal Alaidin Razali
- Wan Hazlina Wan Mohamad
- Wanner Christoph
- Waqar Ayub
- Waseem Karsan
- Wasim Deeb
- Wasim Hanif
- Wataru Ogawa
- Wei Wang
- Wei Wei
- Weijing Bian
- Weiping Hou
- Weixin Kong
- Wen Jiun Liu
- Wen Liu
- Wendy Arriaga
- Wiebke Kaluza-Schilling
- Will Stevens
- William Durham
- William G Herrington
- William G Herrington
- William Hodge
- William Petchey
- Wolf-Adam Seeger
- Wolfgang Seeger
- Wuhanbilige Hundei
- Xavier Rossello
- Xia Song
- Xiangcheng Xiao
- Xiaojing Jiao
- Xiaojue Li
- Xiaoliang Wang
- Xinzhou Zhang
- Xiumei Hu
- Xuejiao Liu
- Xueying Wang
- Yan Li
- Yanmei Xu
- Yanping Wang
- YanRu Qiao
- Yanwu Yu
- Yanyun Xie
- Yao Weng
- Yao Yao
- Yasemin Kavak
- Yasuhiko Furukawa
- Yasuhiko Ito
- Yasuhiko Kanaguchi
- Yasuhiro Suzuki
- Yasushi Iwaita
- Ye Mun Low
- Yee Yan Lee
- Yew Fong Liew
- Yi Loon Tye
- Yik Hong Wong
- Yik Shen Lim
- Ying Hu
- Ying Jiang
- Ying Kuan
- Ying Lu
- Yinghua Chen
- Yohei Ejima
- Yoko Inukai
- Yolanda Miller
- Yong Chieh Chan
- Yonghong Bu
- Yoshiaki Morishita
- Yoshie Shibata
- Yoshifumi Tamura
- Yoshihiko Yamasaki
- Yoshihisa Wada
- Yoshikazu Tamori
- Yoshiki Suzuki
- Yoshimitsu Yamasaki
- Yoshinari Yasuda
- Yoshinori Osaki
- Yoshiro Kato
- Yoshiyuki Hamamoto
- Yosuke Hirakawa
- Yosuke Nakagawa
- Youcef Mostefai
- Young Lee-Barkey
- Yu An
- Yu Chen
- Yu Chen Ong
- Yu Yamanouchi
- Yuana Mohd Yusoff
- Yuichiro Munakata
- Yuji Oe
- Yuka Sato
- Yuka Ueda
- Yukari Miura
- Yuki Fujita
- Yuki Fukao
- Yuki Omori
- Yukihiro Shimizu
- Yukihiro Yamaji
- Yukiko Nakayama
- Yukiko Toyonaga
- Yukiko Wakita
- Yuko Katsuda
- Yuko Makita
- Yuko Okada
- Yuko Orimo
- Yumi Osawa
- Yushi Hirota
- Yusuke Suzuki
- Yutaka Kamimura
- Yuya Nishida
- Yvette Webley
- Yvonne Ehrl
- Yvonne Jackson
- Zabrina Lozon
- Zaid Azhari
- Zaiha Harun
- Zainab Sheriff
- Zanaida Cooper
- Zay Htet
- Zhang Duan Tham
- Zhi-Hong Liu
- Zhirui Zhao
- Zhu Doreen
- Zhuo Tang
- Zohreh Forghani
- Zuber Patel
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2023
- Field of study
Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo