Assets and Barriers to Infection Control on a College Campus

An abstract about a photovoice done concerning infection control on college campus

The Grizzly, February 25, 2010

Airband Date Auction Meets, Surpasses Goal • Drawing the Curtain Opens at the Berman Museum • Spread the Word to End the R Word Next Week • Student-Athlete Advisory Committee Takes UC Athletics Beyond the Fieldhouse • Snow Photos • Author Speaks on Campus About Bringing Nature Home • Skin We\u27re In Addresses Self-Esteem Issues • Cutting Down Waste by Recycling Kegs Instead of Canshttps://digitalcommons.ursinus.edu/grizzlynews/1807/thumbnail.jp

The Grizzly, March 4, 2010

Ursinus Theater presents The Crucible • Political Cartoonist, Author Discusses New Book • CoSA Application, Logo Submission Deadlines Extended • Interest in Bioethics in Medicine Rises at UC • American Heart Month • Ursinus Looks Into The Buried Life • Neshoba Highlights Civil Rights Corruption in Honor of Black History Month • Chat Roulette Gambles with the Issues of Social Networking • Ursinus Lacrosse Looks to Outwork Opposition • Indoor Track & Field Championshiphttps://digitalcommons.ursinus.edu/grizzlynews/1808/thumbnail.jp

Humor-Centered Design: Using Humor as a Rhetorical Approach in Design

My thesis pursues the development of a tool to empower designers and non-designers to better understand humor’s function in design and to encourage the use of humor as a rhetorical device to undertake social problems. Humor research is a field that is largely based on linguistic studies, but because of its multidisciplinary stretch in the past decade has displayed a broad rhetorical influence; however, it has yet to form a substantial relationship with design. Through a literature review of linguistic, rhetorical, and design theories, I identified a set of heuristics that guide how humor should operate in design. I then tested the effectiveness of the heuristics, and with their final revision, applied them to designing for motivational problems associated with public displays of political mobilization. My user research inferred the creation of a mobile instructional tool that guides the collaborative and/or individual production of political communication artifacts (e.g. rally signs), which use humor to confront socially complex issues. The artifacts’ implicit intent is to motivate political mobilization and to found and/or empower communities. My project focus entails the creation and testing of the tool on the individual level. Whether the artifacts created produce the desired effect regarding mobilization and community strength is unknown; Future work should lend itself to testing humorous design’s effect on political mobilization and ability to empower communities.</p

A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial

Background Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework. Methods We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression. Results The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66. Conclusions In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation

Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.

ObjectivesAmong patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant.DesignSecondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722).SettingOne hundred-fifty-three ICUs in 13 countries.PatientsAltogether 2693 critically ill patients with AKI, of whom 994 were North American, 1143 European, and 556 from Australia and New Zealand (ANZ).InterventionsNone.Measurements and main resultsTotal mean FB to a maximum of 14 days was +7199 mL in North America, +5641 mL in Europe, and +2211 mL in ANZ (p p p p p p p p = 0.007).ConclusionsAmong STARRT-AKI trial centers, significant regional practice variation exists regarding FB, timing of initiation of RRT, and initial use of continuous RRT. After adjustment, such practice variation was associated with lower ICU and hospital stay and 90-day mortality among ANZ patients compared with other regions