Symmetry Breaking of Counter-Propagating Light in a Nonlinear Resonator

Spontaneous symmetry breaking is a concept of fundamental importance in many areas of physics, underpinning such diverse phenomena as ferromagnetism, superconductivity, superfluidity and the Higgs mechanism. Here we demonstrate nonreciprocity and spontaneous symmetry breaking between counter-propagating light in dielectric microresonators. The symmetry breaking corresponds to a resonance frequency splitting that allows only one of two counter-propagating (but otherwise identical) states of light to circulate in the resonator. Equivalently, this effect can be seen as the collapse of standing waves and transition to travelling waves within the resonator. We present theoretical calculations to show that the symmetry breaking is induced by Kerr-nonlinearity-mediated interaction between the counter-propagating light. Our findings pave the way for a variety of applications including optically controllable circulators and isolators, all-optical switching, nonlinear-enhanced rotation sensing, optical flip-flops for photonic memories as well as exceptionally sensitive power and refractive index sensors

Dark-Bright Soliton Bound States in a Microresonator

The recent discovery of dissipative Kerr solitons in microresonators has facilitated the development of fully coherent, chip-scale frequency combs. In addition, dark soliton pulses have been observed in microresonators in the normal dispersion regime. Here, we report bound states of mutually trapped dark-bright soliton pairs in a microresonator. The soliton pairs are generated seeding two modes with opposite dispersion but with similar group velocities. One laser operating in the anomalous dispersion regime generates a bright soliton microcomb, while the other laser in the normal dispersion regime creates a dark soliton via Kerr-induced cross-phase modulation with the bright soliton. Numerical simulations agree well with experimental results and reveal a novel mechanism to generate dark soliton pulses. The trapping of dark and bright solitons can lead to light states with the intriguing property of constant output power while spectrally resembling a frequency comb. These results can be of interest for telecommunication systems, frequency comb applications, ultrafast optics and soliton states in atomic physics

Universal symmetry-breaking dynamics for the Kerr interaction of counterpropagating light in dielectric ring resonators

Spontaneous symmetry breaking is an important concept in many areas of physics. A fundamentally simple symmetry-breaking mechanism in electrodynamics occurs between counterpropagating electromagnetic waves in ring resonators, mediated by the Kerr nonlinearity. The interaction of counterpropagating light in bidirectionally pumped microresonators finds application in the realization of optical nonreciprocity (for optical diodes), studies of PT-symmetric systems, and the generation of counterpropagating solitons. Here, we present comprehensive analytical and dynamical models for the nonlinear Kerr interaction of counterpropagating light in a dielectric ring resonator. In particular, we study discontinuous behavior in the onset of spontaneous symmetry breaking, indicating divergent sensitivity to small external perturbations. These results can be applied to realize, for example, highly sensitive near-field or rotation sensors. We then generalize to a time-dependent model, which predicts different types of dynamical behavior, including oscillatory regimes that could enable Kerr-nonlinearity-driven all-optical oscillators. The physics of our model can be applied to other systems featuring Kerr-type interaction between two distinct modes, such as for light of opposite circular polarization in nonlinear resonators, which are commonly described by coupled Lugiato-Lefever equations

Analisis Hukum Islam terhadap penerapan tarif Surge Pricing pada sewa taksi online Uber di wilayah Surabaya

Skripsi ini adalah hasil penelitian lapangan (field research). Rumusan masalahnya: Pertama, bagaimana praktek penerapan tarif surge pricing pada sewa taksi online Uber di wilayah Surabaya. Kedua, bagaimana analisis hukum Islam terhadap penerapan tarif surge pricing pada sewa taksi online Uber di wilayah Surabaya .Data penelitian ini dihimpun melalui observasi, wawancara kemudian dianalisis dengan menggunakan metode deskripsi kualitatif. Penelitian ini menggunakan pola pikir deduktif, yang diawali dengan mengemukakan pengertian-pengertian, teori-teori, atau fakta-fakta yang bersifat umum, yaitu ketentuan-ketentuan hukum Islam mengenai Ija>rah dan Upah dalam hukum Islam yang selanjutnya dipaparkan dari kenyataan yang ada di lapangan mengenai praktik penerapan tarif surge pricing pada sewa taksi online Uber di wilayah Surabaya, kemudian diteliti dan dianalisis.Hasil penelitian menyimpulkan bahwa penerapan tarif surge pricing yang diberlakukan oleh Uber pada saat terjadinya jam jam sibuk yang menggunakan prinsip ekonomi persediaan dan permintaan, dimana jika permintaan sedang tinggi sedangkan persediaan tidak mencukupi maka biaya perjalanan otomatis meningkat. Dalam penerapannya biaya perjalanan akan meingkat antara 1.1x – 5.5x lipat. Hal ini terjadi secara tiba tiba dan menjadikan penumpang membayar biaya yang lebih mahal dibandingkan dengan perjalanan biasa, dan juga hal ini hanya terjadi di wilayah tertentu dan hanya terjadi beberapa menit atau jam saja. Dalam hukum Islam sebernarnya penerapan ini diperbolehkan, akan tetapi harus diberlakukan secara adil, jelas, transparan dan melihat kerelaan antara penumpang dengan driver. Dan dalam hal ini uber juga memberlakukan perjanjian baku yang terdapat pada buku panduan uber yang sedikit menerangkan tentang adanya tarif surge pricing ini, jadi dengan adanya perjanjian baku ini Uber sudah benar dalam penerapan adanya tarif surge pricing ini.Sejalan dengan kesimpulan di atas, maka disarankan kepada Uber supaya memberi fasilitas kepada pelanggan untuk juga mengetahui di mana atau akan terjadinya penerapan tarif surge pricing dan kepada pengguna layanan Uber agar jika terkena penerapan tarif surge pricing untuk bersabar menunggu hingga harga kembali normal atau tetap memesan taksi online uber dengan cepat agar tarif tidak semakin naik, dan juga kepada driver agar tidak memanfaatkan keadaan saat terjadinya penerapan tarif surge pricing

A Kerr Polarization Controller

Kerr-effect-induced changes of the polarization state of light are well known in pulsed laser systems. An example is nonlinear polarization rotation, which is critical to the operation of many types of mode-locked lasers. Here, we demonstrate that the Kerr effect in a high-finesse Fabry-Pérot resonator can be utilized to control the polarization of a continuous wave laser. It is shown that a linearly-polarized input field is converted into a left- or right-circularly-polarized field, controlled via the optical power. The observations are explained by Kerr-nonlinearity induced symmetry breaking, which splits the resonance frequencies of degenerate modes with opposite polarization handedness in an otherwise symmetric resonator. The all-optical polarization control is demonstrated at threshold powers down to 7 mW. The physical principle of such Kerr effect-based polarization controllers is generic to high-Q Kerr-nonlinear resonators and could also be implemented in photonic integrated circuits. Beyond polarization control, the spontaneous symmetry breaking of polarization states could be used for polarization filters or highly sensitive polarization sensors when operated close to the symmetry-breaking point

Regioselective Glycosylation Strategies for the Synthesis of Group Ia and Ib Streptococcus Related Glycans Enable Elucidating Unique Conformations of the Capsular Polysaccharides

Group B Streptococcus serotypes Ia and Ib capsular polysaccharides are key targets for vaccine development. In spite of their immunospecifity these polysaccharides share high structural similarity. Both are composed of the same monosaccharide residues and differ only in the connection of the Neu5Acα2-3Gal side chain to the GlcNAc unit, which is a β1-4 linkage in serotype Ia and a β1-3 linkage in serotype Ib. We described development of efficient regioselective routes for GlcNAcβ1-3[Glcβ1-4)]Gal synthons giving access to different GBS Ia and Ib repeating unit frameshifts. These glycans were used to probe the conformation and molecular dynamics of the two polysaccharides, highlighting the different presentation of the protruding Neu5Acα2-3Gal moieties on the polysaccharide backbones and a higher flexibility of Ib polymer compared to Ia which can impact epitope exposure.Bio-organic Synthesi

Nonlinear enhanced microresonator gyroscope

Optical gyroscopes based on the Sagnac effect have been the mainstay of inertial navigation in aerospace and shipping for decades. These gyroscopes are typically realized either as ring-laser gyroscopes (RLGs) or fiber-optic gyroscopes (FOGs). With the recent rapid progress in the field of ultrahigh-quality optical whispering-gallery mode and ring microresonators, attention has been focused on the development of microresonator-based Sagnac gyroscopes as a more compact alternative to RLGs and FOGs. One avenue that has been explored is the use of exceptional points in non-Hermitian systems to enhance the responsivity to rotation. We use a similar phenomenon, namely, the critical point of a spontaneous symmetry-breaking transition between counterpropagating light, to demonstrate a microresonator gyroscope with a responsivity enhanced by a factor of around 104. We present a proof-of-principle rotation measurement as well as a characterization of the system’s dynamical response, which shows the universal critical behaviors of responsivity enhancement and critical slowing down, both of which are beneficial in an optical gyroscope. We believe that this concept could be used to realize simple and cheap chip-based gyroscopes with sensitivities approaching those of today’s RLGs and FOGs

Chemical Synthesis and Immunological Evaluation of Fragments of the Multiantennary Group-Specific Polysaccharide of Group B Streptococcus.

Group B Streptococcus (GBS) is a Gram-positive bacterium and the most common cause of neonatal blood and brain infections. At least 10 different serotypes exist, that are characterized by their different capsular polysaccharides. The Group B carbohydrate (GBC) is shared by all serotypes and therefore attractive be used in a glycoconjugate vaccine. The GBC is a highly complex multiantennary structure, composed of rhamnose rich oligosaccharides interspaced with glucitol phosphates. We here report the development of a convergent approach to assemble a pentamer, octamer, and tridecamer fragment of the termini of the antennae. Phosphoramidite chemistry was used to fuse the pentamer and octamer fragments to deliver the 13-mer GBC oligosaccharide. Nuclear magnetic resonance spectroscopy of the generated fragments confirmed the structures of the naturally occurring polysaccharide. The fragments were used to generate model glycoconjugate vaccine by coupling with CRM197. Immunization of mice delivered sera that was shown to be capable of recognizing different GBS strains. The antibodies raised using the 13-mer conjugate were shown to recognize the bacteria best and the serum raised against this GBC fragment-mediated opsonophagocytic killing best, but in a capsule dependent manner. Overall, the GBC 13-mer was identified to be a highly promising antigen for incorporation into future (multicomponent) anti-GBS vaccines.Bio-organic Synthesi

Procjena cito-/genotoksičnosti irinotekana u V79-stanicama primjenom komet-testa, mikronukleus-testa i testa kromosomskih aberacija

Irinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 μg mL-1), recommended monotherapy dose (9 μg mL-1), and recommended combined therapy dose (4.5 μg mL-1) of irinotecan were studied on V79 cells using the comet assay, chromosome aberration assay, and micronucleus test. The cells were treated with irinotecan for 2 h or 24 h. The statistical signifi cance of the results was determined using the one-way ANOVA test and a nonparametric Mann Whitney U test. The comet assay did not show dose-dependent or time-dependent effects. The chromosome aberration analysis showed large DNA rearrangements, i.e., chromosome exchanges. Although the exposed cultures showed a signifi cant increase in micronucleated cells in respect to control, no dose-dependent relation was established among the treated cultures. Timedependent effect was also not observed.Irinotekan je citotoksični lijek koji inhibira enzim DNA-topoizomerazu I. U širokoj je primjeni u terapiji metastatskog karcinoma kolona i rektuma. U uvjetima in vitro primjenom komet-testa, analize kromosomskih aberacija i mikronukleus-testa na V79-stanicama istražili smo genotoksični učinak maksimalne pojedinačne doze (18 μg mL-1), preporučene monoterapijske doze (9 μg mL-1) i preporučene doze irinotekana za kombiniranu terapiju (4,5 μg mL-1). Kulture stanica bile su tretirane irinotekanom 2 h i 24 h. Statistička značajnost određivana je jednosmjernim ANOVA-testom i neparametrijskim Mann Whitneyevim U-testom. Komet-testom nije utvrđen učinak koncentracije i/ili vremena izloženosti. Analiza kromosomskih aberacija pokazala je prisutnost izmjena kromatida, tj. porast broja triradijusa i tetraradijusa. Iako je u kulturama stanica izloženi irinotekanu opažen značajan porast broja mikronukleusa u odnosu na kontrolu, nije uočena ovisnost o dozi lijeka ni o vremenu izloženosti u opisanim eksperimentalnim uvjetima. Dobiveni rezultati upućuju na genotoksičnost irinotekana za V79-stanice. Nijednom od primijenjenih metoda nije utvrđena ovisnost učinka irinotekana o vremenu ili dozi