34 research outputs found
STAKEHOLDERS MANAGEMENT ISSUES AND LEADERSHIP IN PROJECT MANAGEMENT: THE WAY FORWARD
Abstract This article examines the roles of a project manager leadership in tackling project stakeholders' management issues in the aim to deliver a successful project. It argues that while it is indeed delivering an outstanding project is a big challenge, but perception of project success varies from stakeholder to another. Therefore, a lack of deep stakeholders' analysis "identification, prioritization, and interest assessment" will lead to divergence among stakeholders 'perception of project success criteria and project success in general. Project manager leadership qualities and traits play a key role in accurately nailing down the project stakeholders' web to enhance the effectiveness of cooperation, collaboration, consultation, and communicating with the different project stakeholders in the aim to shape their expectations and consolidate a common project success criteria list
LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib
Gastrointestinal tumors; Tyrosine kinase inhibitorsTumores gastrointestinales; Inhibidores de la tirosina cinasaTumors gastrointestinals; Inhibidors de la tirosina cinasaGastrointestinal stromal tumor (GIST), the most common sarcoma, is mainly caused by an oncogenic mutation in the KIT receptor tyrosine kinase. Targeting KIT using tyrosine kinase inhibitors, such as imatinib and sunitinib, provides substantial benefit; however, in most patients, the disease will eventually progress due to KIT secondary mutations leading to treatment failure. Understanding how GIST cells initially adapt to KIT inhibition should guide the selection of appropriate therapies to overcome the emergence of resistance. Several mechanisms have been broadly implicated in the resistance to imatinib anti-tumoral effects, including the reactivation of MAPK signaling upon KIT/PDGFRA targeted inhibition. This study provides evidence that LImb eXpression 1 (LIX1), a protein we identified as a regulator of the Hippo transducers YAP1 and TAZ, is upregulated upon imatinib or sunitinib treatment. LIX1 silencing in GIST-T1 cells impaired imatinib-induced MAPK signaling reactivation and enhanced imatinib anti-tumor effect. Our findings identified LIX1 as a key regulator of the early adaptative response of GIST cells to targeted therapies.This work was supported by Inserm Transfert (CoPoc N°; MAT-PI-13315-A-02 to SF), by the Association contre les Myopathies (AFM N° 23800 to SF), and by Ligue RĂ©gionale Contre le Cancer Languedoc-Roussillon (2020 to P.d.S.B). SRD is funded by the âAgence Nationale de la Rechercheâ (ANR-21-CE14-0017). This work was also supported by institutional funds from the University of Montpellier, INSERM, and CNRS
CO2 Reforming of Methane over LaNiO3 Perovskite Supported Catalysts: Influence of Silica Support
The study presents the dry reforming of methane using natural Kaolin silica as catalyst support. The silica-supported LaNiO3 perovskite catalysts (20LaNiO3/SiO2 and 40LaNiO3/SiO2) and bulk LaNiO3 catalyst were synthesized by auto-combustion method. The resulting catalysts were characterized by X-ray diffraction (XRD), N2 adsorption - desorption isotherm measurement, scanning electron microscopy (SEM) and temperature-programmed reduction (TPR). After reduction at 700 °C, they were used as catalysts for the reaction of dry reforming of methane into synthesis gas at atmospheric pressure at 800 °C. The reduced 40LaNiO3/SiO2 exhibited high catalytic activity. This result was attributed to the small Ni metallic particles obtained from the reduced perovskite highly dispersed on the support and the good reducibility. The increase of reduction temperature at 800 °C resulted in a further enhancement of the catalytic performance of 40LaNiO3/SiO2 catalyst. Copyright © 2019 BCREC Group. All rights reserved
Nanocrystalline diamond films synthetized at low temperature by distributed plasma : from growth process to applications
Ce travail de thĂšse avait pour objectif la comprĂ©hension et le contrĂŽle du procĂ©dĂ© de croissance de films de diamant nanocristallin (DNC) Ă basse tempĂ©rature par dĂ©pĂŽt chimique en phase vapeur assistĂ© par plasma micro- onde distribuĂ© (PMD) en vue dâapplications spĂ©cifiques. Deux axes de travail ont Ă©tĂ© suivis pour atteindre cet objectif : (i) une Ă©tude « matĂ©riau » visant Ă Ă©tudier les potentialitĂ©s du rĂ©acteur PMD Ă rĂ©aliser des films de DNC Ă basse tempĂ©rature avec des caractĂ©ristiques rĂ©pondant aux prĂ©requis dâapplications biomĂ©dicales, (ii) une Ă©tude « plasma » sâintĂ©ressant Ă la caractĂ©risation des dĂ©charges basse pression H2/CH4/CO2 et H2/CH4/CO2/N2 utilisĂ©es pour la croissance.Le premier volet de ces Ă©tudes a portĂ© dans un premier temps sur la synthĂšse de films de DNC sur des substrats piĂ©zoĂ©lectriques, tels que lâoxyde de zinc et le nitrure dâaluminium, pour la rĂ©alisation de dispositifs Ă ondes acoustiques guidĂ©es (WLAW). Dans un deuxiĂšme temps nous nous sommes intĂ©ressĂ©s Ă la croissance sur des substrats de gĂ©omĂ©trie complexe, dont lâaboutissement recherchĂ© est la synthĂšse de DNC sur des implants en titane. Les caractĂ©ristiques biologiques de systĂšmes DNC/Ti et DNC/Ti6Al4V ont ensuite Ă©tĂ© investiguĂ©es. Dans un troisiĂšme temps, lâoptimisation du procĂ©dĂ© dâĂ©laboration des films de DNC a Ă©tĂ© menĂ©e en ajoutant de lâazote dans la phase gazeuse.Le deuxiĂšme volet de ces Ă©tudes sâest intĂ©ressĂ© Ă la caractĂ©risation des plasmas H2/CH4/CO2/N2 utilisĂ©s pour la synthĂšse par spectroscopie optique dâĂ©mission et spectroscopie dâabsorption infrarouge afin dâexaminer les effets de lâaddition dâazote dans le mĂ©lange gazeux sur la tempĂ©rature du gaz et la concentration de diffĂ©rentes espĂšces. Les paramĂštres Ă©lectroniques des dĂ©charges H2/CH4/CO2, densitĂ© et tempĂ©rature des Ă©lectrons, ont Ă©tĂ© dĂ©terminĂ©s en fonction des paramĂštres du procĂ©dĂ© par sonde de Langmuir et par une mĂ©thode spectroscopique et la densitĂ© dâhydrogĂšne atomique a Ă©tĂ© mesurĂ©e par actinomĂ©trie.The purpose of This PhD thesis was the understanding and the control of nanocrystalline diamond (NCD) films growth at low temperature using distributed antenna array (DAA) microwave plasma assisted chemical vapor deposition process for specific applications. Two approaches were adopted to reach these objectives: (i) a « material » study aimed at demonstrating the potential of the DAA reactor to synthetize NCD films at low temperature with characteristics required by biomedical applications, (ii) a « plasma » study focused on the diagnostics of H2/CH4/CO2 and H2/CH4/CO2/N2 low-pressure discharges used for NCD growth.The first approach dealt initially with the study of NCD film synthesis at low temperature on piezoelectric substrates such as zinc oxide and aluminum nitride for the achievement of Waveguiding Layer Acoustic Wave (WLAW) devices. That was followed by NCD growth on complex shaped substrates destined for NCD coating of titanium implants. The biological properties of NCD/Ti and NCD/Ti6Al4V systems were then investigated. Finally, the NCD growth process improvement was carried out by adding nitrogen to the gas phase.The second approach focused on the characterization of H2/CH4/CO2/N2 plasmas by optical emission and infrared absorption spectroscopy in order to investigate the effects of nitrogen addition in the gas mixture on gas temperature and species concentration. The electronic parameters of the H2/CH4/CO2 discharges, electron density and temperature, were determined as a function of process parameters by Langmuir probe measurement and by a spectroscopic method and the atomic hydrogen density was measured by actinometry
Films de diamant nanocristallin synthétisés à trÚs basse température par plasma micro-onde distribué : du procédé de croissance aux applications
The purpose of This PhD thesis was the understanding and the control of nanocrystalline diamond (NCD) films growth at low temperature using distributed antenna array (DAA) microwave plasma assisted chemical vapor deposition process for specific applications. Two approaches were adopted to reach these objectives: (i) a « material » study aimed at demonstrating the potential of the DAA reactor to synthetize NCD films at low temperature with characteristics required by biomedical applications, (ii) a « plasma » study focused on the diagnostics of H2/CH4/CO2 and H2/CH4/CO2/N2 low-pressure discharges used for NCD growth.The first approach dealt initially with the study of NCD film synthesis at low temperature on piezoelectric substrates such as zinc oxide and aluminum nitride for the achievement of Waveguiding Layer Acoustic Wave (WLAW) devices. That was followed by NCD growth on complex shaped substrates destined for NCD coating of titanium implants. The biological properties of NCD/Ti and NCD/Ti6Al4V systems were then investigated. Finally, the NCD growth process improvement was carried out by adding nitrogen to the gas phase.The second approach focused on the characterization of H2/CH4/CO2/N2 plasmas by optical emission and infrared absorption spectroscopy in order to investigate the effects of nitrogen addition in the gas mixture on gas temperature and species concentration. The electronic parameters of the H2/CH4/CO2 discharges, electron density and temperature, were determined as a function of process parameters by Langmuir probe measurement and by a spectroscopic method and the atomic hydrogen density was measured by actinometry.Ce travail de thĂšse avait pour objectif la comprĂ©hension et le contrĂŽle du procĂ©dĂ© de croissance de films de diamant nanocristallin (DNC) Ă basse tempĂ©rature par dĂ©pĂŽt chimique en phase vapeur assistĂ© par plasma micro- onde distribuĂ© (PMD) en vue dâapplications spĂ©cifiques. Deux axes de travail ont Ă©tĂ© suivis pour atteindre cet objectif : (i) une Ă©tude « matĂ©riau » visant Ă Ă©tudier les potentialitĂ©s du rĂ©acteur PMD Ă rĂ©aliser des films de DNC Ă basse tempĂ©rature avec des caractĂ©ristiques rĂ©pondant aux prĂ©requis dâapplications biomĂ©dicales, (ii) une Ă©tude « plasma » sâintĂ©ressant Ă la caractĂ©risation des dĂ©charges basse pression H2/CH4/CO2 et H2/CH4/CO2/N2 utilisĂ©es pour la croissance.Le premier volet de ces Ă©tudes a portĂ© dans un premier temps sur la synthĂšse de films de DNC sur des substrats piĂ©zoĂ©lectriques, tels que lâoxyde de zinc et le nitrure dâaluminium, pour la rĂ©alisation de dispositifs Ă ondes acoustiques guidĂ©es (WLAW). Dans un deuxiĂšme temps nous nous sommes intĂ©ressĂ©s Ă la croissance sur des substrats de gĂ©omĂ©trie complexe, dont lâaboutissement recherchĂ© est la synthĂšse de DNC sur des implants en titane. Les caractĂ©ristiques biologiques de systĂšmes DNC/Ti et DNC/Ti6Al4V ont ensuite Ă©tĂ© investiguĂ©es. Dans un troisiĂšme temps, lâoptimisation du procĂ©dĂ© dâĂ©laboration des films de DNC a Ă©tĂ© menĂ©e en ajoutant de lâazote dans la phase gazeuse.Le deuxiĂšme volet de ces Ă©tudes sâest intĂ©ressĂ© Ă la caractĂ©risation des plasmas H2/CH4/CO2/N2 utilisĂ©s pour la synthĂšse par spectroscopie optique dâĂ©mission et spectroscopie dâabsorption infrarouge afin dâexaminer les effets de lâaddition dâazote dans le mĂ©lange gazeux sur la tempĂ©rature du gaz et la concentration de diffĂ©rentes espĂšces. Les paramĂštres Ă©lectroniques des dĂ©charges H2/CH4/CO2, densitĂ© et tempĂ©rature des Ă©lectrons, ont Ă©tĂ© dĂ©terminĂ©s en fonction des paramĂštres du procĂ©dĂ© par sonde de Langmuir et par une mĂ©thode spectroscopique et la densitĂ© dâhydrogĂšne atomique a Ă©tĂ© mesurĂ©e par actinomĂ©trie
A Dynamic 3D Geometry Compression Scheme Based On The Lifted Wavelet Transform
In distributed environments, efficient visual information sharing is critical for effective communication in real-time engineering collaboration. Methods of geometry compression are needed for high-volume geometry data distribution over networks with limited bandwidths and heterogeneous storage capacities. In this paper, a new compression scheme for timevarying 3D geometry is introduced to support engineering and scientific visualization while showing potential for the audiovisual presentation and entertainment fields. This hybrid approach allows geometric and topological information to be uniformly encoded as volume grid values then compressed based on the lifted wavelet transform. The compression ratio is significantly increased without compromising surface quality due to rescaling and integer-to-integer lifting. This approach also allows for scalability in terms of additional data streams such as color, audio, and other types of concurrent data necessary for the desired customization of this method. Copyright © 2007 by ASME
Solvability of a third-order system of nonlinear difference equations via a generalized Fibonacci sequence
In this paper, we solve in closed-form the following third-order system of nonlinear difference equations x_{n+1}=(y_ny_{n-1}x^p_{n-1})/(x_{n}(a_n y^q_{n-2}+b_n y_n y_{n-1})), y_{n+1}=(x_n x_{n-1}y^q_{n-1})/(y_{n}(c_n x^p_{n-2}+d_n x_n x_{n-1})), p, q â â, n â â_0 where the initial values xâi, yâi, i = 0, 1, 2 and the parameters (a_n)nââ_0, (b_n)nââ0, (cn)nââ_0, (dn)nââ_0 are non-zero real numbers. The form of the solutions of the one dimensional case of our system and a more general system defined by one to one functions are also presented
Les chaßnes arabes de télévision d'information en continu
L essor des chaĂźnes satellitaires arabes Ă l Ă©chelle rĂ©gionale et mondiale a mĂ©tamorphosĂ© l espace mĂ©diatique arabe. Le dĂ©but des annĂ©es 1990 annonce la mondialisation, et l acquisition de la technologie satellitaire dans les pays arabes semble ĂȘtre le dĂ©but d une nouvelle Ăšre dans une rĂ©gion oĂč se conjuguent la rentabilitĂ© financiĂšre et l influence politique et idĂ©ologique des acteurs. Les chaĂźnes de tĂ©lĂ©visions d information en continu sont le modĂšle appropriĂ© qui traduit ce schĂ©ma dans une rĂ©gion politiquement, Ă©conomiquement et culturellement complexe. C est l avĂšnement d Al Jazeera et sa couverture de la guerre en Afghanistan en 2001 et par la suite la guerre en Irak en 2003 qui a bien façonnĂ© une large proportion de l opinion publique arabe. D autres chaĂźnes arabes du mĂȘme genre en quĂȘte d influence se sont multipliĂ©es en un temps record dans cet espace mĂ©diatique, telles qu Al Arabiya, Al Manar, ONTV, Al Mayadeen et d autres, le transformant ainsi de façon radicale. L audience arabe est Ă©galement convoitĂ©e par des chaĂźnes occidentales arabophones financĂ©es par les gouvernements respectifs de leurs pays comme la chaĂźne amĂ©ricaine Al Hurra, française France 24, britannique la BBC Arabic ou allemande DW . L Ă©tude porte sur le rĂŽle de ces chaĂźnes d information dans les changements qu a connus et connait Ă l heure actuelle la rĂ©gion du Moyen Orient, et leur degrĂ© d engagement pour la diffusion et l ancrage des valeurs et pratiques dĂ©mocratiques. Dans quelle mesure les mĂ©tamorphoses propres de ces chaĂźnes sont susceptibles de rĂ©vĂ©ler les transformations les plus profondes des sociĂ©tĂ©s arabes? L objet de cette recherche est de saisir les modalitĂ©s de l avĂšnement des chaĂźnes de tĂ©lĂ©visions d information en continu, de dĂ©finir les objectifs de leur crĂ©ation et d identifier les acteurs de toute sorte afin d en discerner les consĂ©quences sur le plan mĂ©diatique et gĂ©opolitique.The Arab TV satellite channels growth at the regional and global scale metamorphosed Arabic media space. The early 90s impulse globalization and satellite technologies acquisition by Arab countries seems to be the beginning of a new era in this region where combined financial profitability, political influence and ideological actors. TV Channels rolling news and continuously broadcast information are the appropriate model that reflects this scheme in a region politically, economically and culturally so complex and mostly complicated. It is the advent of the Arab TV channel Al Jazeera and its Afghanistan war coverage in 2001 and thereafter the Iraq war in 2003 that have shaped a huge proportion of Arab public opinion. Other TV channels of the same kind are multiplied and diversified in a record time, such as Al Arabiya, Al Manar, ONTV, Al Mayadeen, etc. Arabic audience is also coveted by Western Arabic TV channels financed by western countries and their governments, such as the U.S. channel Al Hurra, French once 24 French, British one BBC Arabic or the German one DW. The study focuses on the role of the TV channels specialized on news in r evolutions known and continuously know at present the Middle East region.What is the degree of their commitment to broadcasting and anchoring universal values and democratic practices? What is the degree of influence may reveal changes in the Arab societies? The purpose of this research is to understand how the advent of TV Channels rolling news, set goals, and identify actors in order to recognize the consequences over the media plans and geopolitical perspectives.PARIS-CUJAS-BU Droit (751052119) / SudocSudocFranceF
GerstenhaberâSchack cohomology for Hom-bialgebras and deformations
South America [Correction: Central America, Colombia] Cotton for exportColorVolume 94, Page