852 research outputs found
PCV29: PERSISTENCY OF TREATMENT IN PATIENTS INITIATED ON FIVE DIFFERENT CLASSES OF ANTIHYPERTENSIVE THERAPY: A PHARMACO-UTILIZATION AND PHARMACO-ECONOMIC ANALYSIS
PCV76 Standard Costs and Resources Allocation in Attainment of Target Lipid Levels among Experienced Statin Users: Results From the STAR Study (Statins Target Assessment in Real Practice)
Egorov property in perturbed cat map
We study the time evolution of the quantum-classical correspondence (QCC) for
the well known model of quantised perturbed cat maps on the torus in the very
specific regime of semi-classically small perturbations. The quality of the QCC
is measured by the overlap of classical phase-space density and corresponding
Wigner function of the quantum system called quantum-classical fidelity (QCF).
In the analysed regime the QCF strongly deviates from the known general
behaviour in particular it decays faster then exponential. Here we study and
explain the observed behavior of the QCF and the apparent violation of the QCC
principle.Comment: 12 pages, 7 figure
Folds and Buckles at the Nanoscale: Experimental and Theoretical Investigation of the Bending Properties of Graphene Membranes
The elastic properties of graphene crystals have been extensively investigated, revealing unique properties in the linear and nonlinear regimes, when the membranes are under either stretching or bending loading conditions. Nevertheless less knowledge has been developed so far on folded graphene membranes and ribbons. It has been recently suggested that fold-induced curvatures, without in-plane strain, can affect the local chemical reactivity, the mechanical properties, and the electron transfer in graphene membranes. This intriguing perspective envisages a materials-by-design approach through the engineering of folding and bending to develop enhanced nano-resonators or nano-electro-mechanical devices. Here we present a novel methodology to investigate the mechanical properties of folded and wrinkled graphene crystals, combining transmission electron microscopy mapping of 3D curvatures and theoretical modeling based on continuum elasticity theory and tight-binding atomistic simulations
Phase separation and pairing regimes in the one-dimensional asymmetric Hubbard model
We address some open questions regarding the phase diagram of the
one-dimensional Hubbard model with asymmetric hopping coefficients and balanced
species. In the attractive regime we present a numerical study of the passage
from on-site pairing dominant correlations at small asymmetries to
charge-density waves in the region with markedly different hopping
coefficients. In the repulsive regime we exploit two analytical treatments in
the strong- and weak-coupling regimes in order to locate the onset of phase
separation at small and large asymmetries respectively.Comment: 13 pages, RevTeX 4, 12 eps figures, some additional refs. with
respect to v1 and citation errors fixe
Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a 'real-world' retrospective cohort study
OBJECTIVE:
The present study investigated the effects of switching to different products of the same off-patent active substance (brand name or generic) on therapy discontinuation or substitution with another molecule of the same class, in patients with cardiovascular disease treated with statins and antihypertensives in a 'real-world' setting.
DESIGN:
A retrospective cohort study in a 'real-world' setting.
SETTING:
Analysis of data performed by integrating administrative databases that included approximately two million individuals who are assisted by the National Health System from three Local Health Units located in three different regions of Italy.
PARTICIPANTS:
All patients aged 6518\u2005years with at least one prescription of simvastatin, ramipril or amlodipine in the period 1 January to 31 December 2010 were included and followed up for 2\u2005years.
MAIN OUTCOME MEASURES:
Prescription refills occurring during follow-up were evaluated. Frequency of discontinuation of therapy or substitution with another molecule of the same class (eg, from simvastatin to a different statin) during follow-up was identified.
RESULTS:
During follow-up, therapy discontinuation or substitution was found to be more frequent in patients switching to a different product of the same active substance compared with non-switching patients (11.5% vs 10.8% and 22.2% vs 20.8% (p=0.002), respectively, in the simvastatin group; 4.0% vs 3.5% and 24.6% vs 22.7% (p<0.001), respectively, in the amlodipine group). In the ramipril group, 8% of patients undertook a therapy substitution to another molecule; no trend towards a lower percentage of substitution was observed in the non-switching group, while 18% of patients discontinued treatment, with a significant difference in favour of patients not switching. These findings were partially confirmed by multivariate analysis.
CONCLUSIONS:
Switches among products of the same active substance are quite common in patients with cardiovascular disease. Our study suggests that switching may expose patients to a higher risk of therapy discontinuation or substitution
Qubit Teleportation and Transfer across Antiferromagnetic Spin Chains
We explore the capability of spin-1/2 chains to act as quantum channels for
both teleportation and transfer of qubits. Exploiting the emergence of
long-distance entanglement in low-dimensional systems [Phys. Rev. Lett. 96,
247206 (2006)], here we show how to obtain high communication fidelities
between distant parties. An investigation of protocols of teleportation and
state transfer is presented, in the realistic situation where temperature is
included. Basing our setup on antiferromagnetic rotationally invariant systems,
both protocols are represented by pure depolarizing channels. We propose a
scheme where channel fidelity close to one can be achieved on very long chains
at moderately small temperature.Comment: 5 pages, 4 .eps figure
PCV83 ADHERENCE WITH ANTIHYPERTENSIVE DRUG TREATMENT: EVIDENCE FROM PRIMARY CARE PRACTICE IN ITALY
Epidemiology of Statin-Treated Patients with Uncontrolled Ldl Levels from Italian Administrative Official Databases
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Health Care Resource Utilization Costs Related to Anaemia Management in Chronic Kidney Disease Non-Dialysed Patients: A Retrospective Clinical and Administrative Database Analysis
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