Effects of mutation and some environmental factors on the physiology and pathogenicity of selected bacteria

Studies with mutants of Staphylococcus aureus lacking some virulence factors suggest that the presence of deoxyribonuclease correlates with mouse pathogenicity of S. aureus, while the ability to ferment mannitol or the possession of coagulases are not required for virulence. Autotrophy investigations on mycobacteria demonstrate a complete correlation between the ability to grow with hydrogen and the species of scotochromogenic mycobacterium tested. All tested strains of M. gordonae, a saprophyte, could grow autotrophically while none of the tested strains of M. scrofulaceum, a clinically important species, possessed this ability. A series of heat tolerant mutants of Pseudomonas fluorescences were obtained which can grow at temperatures up to 54 C, in contrast to a maximum growth temperature of 37 C for the wild type

La Comunidad de Lawrence

During the semester, the class is learning about communities, the meaning and boundaries of communities and what makes a community. For my project, I am going to study the community and city of Lawrence, Massachusetts. Throughout the semester, I will be attending at least 3 different events in Lawrence. This will allow me to learn about the important aspects of the Lawrence community, such as the children, food and home life. The event reports will be the basis of the presentation and the presentation will also include information about the community as a whole

The Gender Wage Gap and the Motherhood Effect

This paper discusses the gender pay gap and how motherhood is a major factor toward the inequalities in the workplace. For this paper, the wage gap is defined as the difference between men and women’s yearly income consisting of hourly or salary wages, overtime, benefits and bonuses. It should be noted that men earn more in every category of work, even the categories that are female-dominated professions

Exploring Shakespearean Influence On Executive Leadership In Finance: A Qualitative Narrative Inquiry

This qualitative narrative inquiry sought to investigate perceptions of executive leaders in finance about how Shakespeare can influence leadership performance. It employed a conceptual framework in dramaturgical analyses (Goffman, 1959) and a theoretical framework in reflective leadership (Schon, 1983). Separate semi-structured interviews were conducted with five participants to gather data, which was coded in vivo. Codes were then analyzed and sorted into themes. The study was driven by two major research questions and a sub-question: The two major research questions and sub-question guiding this study were as follows: (1) What are perceptions of executive leaders in the financial industry about portrayals of leadership in Shakespearean drama and literature?; (2) How does a sample of executive financial leaders describe how Shakespearean drama and literature inform their leadership performance?; and (2.a.) How can the reflective analytical processes developed by leaders be described in context of Shakespearean leadership narrative? The analyses of the data collected in this study revealed two major themes with five (total) sub-themes. The first theme was: Clear Perceptions of Leadership with sub-themes of (1) “Brush Up” Your Shakespeare and (2) On Hamlet. The second major theme was: The Power to Inform Personal Practice, with the sub-themes of (1) “Suck Up All the Arts You Can,” (2) Shakespeare, the Cynic: “What Not to Do,” and (3) Grave Consequences. The study painted a picture of the rigorous emotional landscape of working as an executive in finance and highlighted this sample’s proclivity toward an environment in finance that is conducive to good teamwork

Wages, costs, and prices in the basic steel industry, 1947-49, 1957.

Thesis (Ph.D.)--Boston University

Long-Distance Movements of Anadromous Dolly Varden between Alaska and the U.S.S.R.

Two anadromous Dolly Varden, tagged in the Wulik River, Alaska, during September 1988, were recaptured in the Anadyr River, U.S.S.R., one in August 1989 and one in August 1990. Two additional tag recoveries were made south of the Bering Strait, one near Savoonga on St. Lawrence Island, Alaska, and one near Egavik in Norton Sound, Alaska. The greatest distance traveled was 1690 km. This is the first record of fish movement between freshwaters of Alaska and the U.S.S.R. and the longest documented movement of a Dolly Varden or Arctic char.Key words: Dolly Varden, Salvelinus malma, movements, U.S.S.R., AlaskaRÉSUMÉ. Deux Dolly Varden potamotoques étiquetés dans la rivière Wulik en Alaska au cours du mois de septembre 1988 ont été recapturés dans le fleuve Anadyr, en Union soviétique, l’un en août 1989 et l’autre en août 1990. Deux autres captures de poissons étiquetés ont eu lieu au sud dudétroit de Béring, l’une près de Savoonga sur l’île Saint Lawrence en Alaska et l’autre près d’Egavik dans Norton Sound en Alaska. La distance maximale parcourue était de 1690 km. Cela représente le premier cas documenté de migration de poissons entre les eaux douces de l’Alaska et de l’Union soviétique, ainsi que la migration documentée la plus longue d’un Dolly Varden ou omble chevalier.Mots clés: Dolly Varden, Salvelinus malma, migration, Union soviétique, Alask

Using the Diels-Alder Reaction in the Synthesis of Biologically Interesting Molecules: Targets of Opportunity

This thesis is composed of reports on two projects, which are described separately in two chapters. The first project described (Chapter 1) involves the synthesis of a series of molecules that contain a 1,4-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxy-imide core structure. These types of molecules represent a class of analogues of the natural product cantharidin, a potent cytotoxic agent isolated from Meloidae insects. Cantharidin and cantharidin-like small molecules have been extensively studied in literature as potential leads in new anti-cancer medications. A series of 1,4-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3- dicarboxy-imides are also being investigated by researchers at Bristol-Meyers-Squibb (BMS) as prospective treatments of prostate cancer (PC). PC is the most common malignancy among men in the United States and the second most common cause of cancer-related death worldwide. The need for novel prostate cancer medications arises from patient resistance to current PC drugs. Synthesis and biological activity of a series of cantharidin/BMS-641988 analogues will be presented. Theoretical studies to identify our next generation of synthetic targets and their potential application in the treatment of PC will also be discussed. The second project (Chapter 2) describes new methodology studies to provide access to 9-membered lactones. This structural moiety is an unusual, yet frequently observed structural feature of natural products. The synthesis of medium sized cyclic functional groups, namely 9-membered lactones, is still a formidable challenge in synthetic organic chemistry. Studies toward a facile, three step synthesis of molecules containing 9-membered lactones is proposed and synthetic efforts towards the appropriate precursors will be discussed

Multi-Satellite Attitude Prediction program/Orbiting Solar Observatory-8 (MSAP/OSO-8) operating guide

The sun's lower corona and chromosphere and their interaction in the X-ray and ultraviolet (UV) spectral regions were investigated to better understand the transport of energy from the photosphere to the corona. The interaction between the solar electromagnetic and particle radiation and the earth's environment was studied and the background component of cosmic X-rays was discussed