Towards a political economy of the use of research assistants: reflections from fieldwork in Tanzania and Mozambique

Research assistants play a vital role in the research process, often acting as more than just translators or interpreters. However, their contributions to and impacts on the research process and outcomes often remain unacknowledged or unaccounted for. We build on previous work that looks at the subjective relations between the researcher, research assistant and research participant to explore this issue. In particular, drawing on a political economy approach, we look at how research assistants, through their objective position, mediate relations between researcher and participants, and also how power relations and different configurations of roles influence the research process and outcomes. Our analysis concludes that ignoring the role of research assistants in empirical research will lead to flawed processes, biased data and possibly misleading results

Employers’ responses to the HIV epidemic in sub-Saharan Africa: revisiting the evidence

Do employers have a role to play to support people living with HIV? The literature on sub-Saharan Africa points to the existence of a positive business case that sees firms as incentivised to provide HIV-related services to HIV positive workers . However, the evidence is narrow and incomplete, with the business case holding for a limited number of formal sector skilled workers, leaving out the majority of people living with HIV. If employers are to play a role, policy makers need to create conducive conditions for positive responses, in addition to – not in replacement of – strengthening public health care systems

Exploring the relationship between population mobility and HIV risk: evidence from Tanzania

Migration and population mobility has long been regarded as an important structural driver of HIV. Following initial concerns regarding the spatial spread of the disease, mobile populations are viewed to engage in higher levels of risky sexual behaviours than non-mobile groups. However, beyond the case studies of mineworkers and truck drivers, the statistical evidence is inconclusive, suggesting that the relationship between mobility and risk is not well understood. This study investigated how engaging in specific livelihoods that involve mobility influences sexual behaviour and HIV risk. A qualitative research project, including focus groups and in-depth interviews with key mobile groups, was conducted in Northern Tanzania. The findings show that the patterns and conditions of moving related to the requirements of each different economic activity influence the nature of relationships that mobile groups have whilst away, how and where local sexual networks are accessed, and the practicalities of having sex. This has further implications for condom use. Risk behaviours are also shaped by local sexual norms related to transactional sex, emphasising that the roles of mobility and gender are interrelated, overlapping, and difficult to disentangle

Aerodynamic Characteristics of Two Rotary Wing UAV Designs

This paper presents the results of an experimental investigation of two rotary-wing UAV designs. The primary goal of the investigation was to provide a set of interactional aerodynamic data for an emerging class of rotorcraft. The present paper provides an overview of the test and an introduction to the test articles, and instrumentation. Sample data in the form of a parametric study of fixed system lift and drag coefficient response to changes in configuration and flight condition for both rotor off and on conditions are presented. The presence of the rotor is seen to greatly affect both the character and magnitude of the response. The affect of scaled stores on body drag is observed to be dependent on body shape

Interstitial lung abnormalities in patients with early rheumatoid arthritis: A pilot study evaluating prevalence and progression.

OBJECTIVE:Pulmonary disease is a leading cause of morbidity and mortality in rheumatoid arthritis (RA). In this study, we investigated the prevalence and progression of interstitial lung abnormalities (ILA) in a prospective cohort study of 18 subjects with early RA. METHODS:Eighteen adults diagnosed with anti-citrullinated protein-antibody-positive RA within the prior year underwent baseline high-resolution computed tomography (HRCT), symptom assessment, and pulmonary function and laboratory testing. The follow-up HRCT and clinical assessment were completed after 1 year. RESULTS:Seven of the 18 patients (39%) had baseline HRCT abnormalities including septal thickening, honeycombing, ground glass opacities, and/or traction bronchiectasis. At follow-up, 6 out of the 7 subjects (86%) with ILAs at baseline exhibited progression, while 10 out of 11 (91%) without ILAs at baseline remained stable. A higher Clinical Chronic Obstructive Pulmonary Disease Questionnaire score was associated with both the presence and progression of HRCT abnormalities (10 vs 2, p=0.045; 10 vs 2, p=0.009, respectively). C-reactive protein (CRP) trended higher in patients with radiologic abnormalities (3.5 mg/L vs 1.1 mg/L, p=0.08) and was significantly higher in those with progression (3.5 mg/L vs 1 mg/L, p=0.024). Smoking, pulmonary function, and autoantibodies were not associated with HRCT abnormalities. CONCLUSION:ILAs are prevalent in patients with early RA. If identified at baseline, radiographic progression of ILAs after 1 year is likely, while those without ILAs at baseline are unlikely to develop new ILAs. In addition, early respiratory symptoms and higher CRP levels may correlate with the presence and progression of underlying ILAs

Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease leading to considerable disability over time. The disease can be characterized by the presence of multiple autoantibodies in the serum and synovial fluid. Microbial dysbiosis is proposed to play a role in the pathogenesis of RA. Increased systemic bacterial exposure leads to elevated levels of antimicrobial response factors (ARFs) in the circulation. In the present study, we tested whether RA patients have increased levels of ARFs by analyzing the levels of multiple ARFs in serum from RA patients and healthy age and sex-matched controls. The levels of soluble CD14 (sCD14), lysozyme, and CXCL16 were significantly elevated in RA patients compared to healthy controls. Lipopolysaccharide binding protein (LBP) levels remained unchanged in RA patients compared to healthy controls. A positive correlation of LBP with rheumatoid factor (RF) was also found in RA subjects. Interestingly, the levels of anti-endotoxin core antibodies (EndoCAb) IgM, total IgM, EndoCAb IgA, and total IgA were significantly elevated in RA patients compared to healthy controls. No significant changes in the levels of EndoCAb IgG and total IgG were observed in RA patients compared to healthy controls. Furthermore, lysozyme and CXCL16 levels were positively correlated with disease severity among RA subjects. Increases in the levels of several ARFs and their correlations with clinical indices suggest systemic microbial exposure in the RA cohort. Modulation of microbial exposure may play an important role in disease pathogenesis in individuals with RA

Navier-Stokes Simulation of a Heavy Lift Slowed-Rotor Compound Helicopter Configuration

Time accurate numerical simulations were performed using the Reynolds-averaged Navier-Stokes (RANS) flow solver OVERFLOW for a heavy lift, slowed-rotor, compound helicopter configuration, tested at the NASA Langley 14- by 22-Foot Subsonic Tunnel. The primary purpose of these simulations is to provide support for the development of a large field of view Particle Imaging Velocimetry (PIV) flow measurement technique supported by the Subsonic Rotary Wing (SRW) project under the NASA Fundamental Aeronautics program. These simulations provide a better understanding of the rotor and body wake flows and helped to define PIV measurement locations as well as requirements for validation of flow solver codes. The large field PIV system can measure the three-dimensional velocity flow field in a 0.914m by 1.83m plane. PIV measurements were performed upstream and downstream of the vertical tail section and are compared to simulation results. The simulations are also used to better understand the tunnel wall and body/rotor support effects by comparing simulations with and without tunnel floor/ceiling walls and supports. Comparisons are also made to the experimental force and moment data for the body and rotor

Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients

Background Extra-articular manifestations of rheumatoid arthritis (RA), potentially due to systemic inflammation, include cardiovascular disease and sarcopenic obesity. Adiponectin, an adipose-derived cytokine, has been implicated in inflammatory processes in RA, but little is known regarding its association with inflammation in a pre-clinical period. Therefore, we investigated whether adiponectin was associated with inflammatory markers in individuals at risk for RA, and whether RA-related autoimmunity modifies these associations. Methods We analyzed samples from 144 first-degree relatives (FDRs) of RA probands, of whom 23 were positive for anti-cyclic citrullinated peptide antibody and/or ≥ 2 rheumatoid factor isotypes (IgM, IgG or IgA). We called this phenotype the ‘high risk autoantibody profile (HRP)’ as it has been shown in prior work to be >96% specific for future RA. We measured adiponectin, cytokines, and high-sensitivity C-reactive protein (hsCRP). Using linear mixed effects models, we evaluated interaction between HRP positivity and adiponectin on inflammatory markers, adjusting for age, sex, ethnicity, body mass index, pack-years smoking, and use of cholesterol-lowering medications. Results In everyone, adiponectin concentration was inversely associated with hsCRP and IL-1β in adjusted models, where a 1% higher adiponectin was associated with a 26% lower hsCRP (p = 0.04) and a 26% lower IL-1β (p = 0.04). Significant interactions between HRP and adiponectin for associations with GM-CSF, IL-6, and IL-9 were detected in fully adjusted models (p = 0.0006, p = 0.006, p = 0.01, respectively). In HRP positive FDRs but not HRP negative FDRs, a 1% higher adiponectin was associated with 97% higher GM-CSF, 73% higher IL-6, and 54% higher IL-9 concentrations. Conclusions Adiponectin associates with inflammatory markers, and these associations differ in individuals with a high-risk autoantibody profile compared with those without. The interaction between adiponectin and autoimmunity warrants further investigation into the potential systemic effects of RA-related autoantibodies and adiponectin on inflammation in the absence of clinically apparent RA

Revisiting the economics of transactional sex: evidence from Tanzania

Transactional sex has been identified as one of the key structural drivers of the HIV epidemic. Mainstream economic analyses of this practice primarily conceptualise transactional sex in the language of rational choice, with the focus on behavioural decisions that women make over whether to engage in transactional interactions (or not). However, whilst providing some important insights in relation to the role of poverty and the importance of acknowledging that women are more than passive agents, these approaches fail to address the social and economic complexities of this practice that are reflected in the broader literature. Further, due to the technical framework used, there is a failure to deal with the broader socio-economic and historical underpinnings of this practice. Using evidence from fieldwork undertaken in Tanzania, we revisit the economics of transactional sex, and offer an alternative economic approach to understanding this practice. We explore the notion that transactional sex is an established local sexual norm, and how this norm is creatively applied and reapplied in a range of situations by different actors, including through participation in local value chains. Our analysis has a number of implications for future prevention efforts that differ from the current focus on microfinance as a means of empowering women

INITIAL ASSESSMENT OF SURFACE PRESSURE CHARACTERISTICS OF TWO ROTARY WING UAV DESIGNS

This paper presents results of an experimental investigation of two rotary-wing UAV designs. The primary goal of the investigation was to provide a set of interactional aerodynamic data for an emerging class of rotorcraft. The present paper provides an overview of the test and an introduction to the test articles, and instrumentation. Sample data in the form of fixed system pressure coefficient response to changes in configuration attitude and flight condition for both rotor off and on conditions are presented. The presence of the rotor is seen to greatly affect the magnitude of the response. Pressure coefficients were measured using both conventional pressure taps and via pressure sensitive paint. Comparisons between the two methods are presented and demonstrate that the pressure sensitive paint is a promising method; however, further work on the technique is required