Automatic building information model query generation

Energy efficient building design and construction calls for extensive collaboration between different subfields of the Architecture, Engineering and Construction (AEC) community. Performing building design and construction engineering raises challenges on data integration and software interoperability. Using Building Information Modeling (BIM) data hub to host and integrate building models is a promising solution to address those challenges, which can ease building design information management. However, the partial model query mechanism of current BIM data hub collaboration model has several limitations, which prevents designers and engineers to take advantage of BIM. To address this problem, we propose a general and effective approach to generate query code based on a Model View Definition (MVD). This approach is demonstrated through a software prototype called QueryGenerator. By demonstrating a case study using multi-zone air flow analysis, we show how our approach and tool can help domain experts to use BIM to drive building design with less labour and lower overhead cost.published_or_final_versio

Keith County, Nebraska, Map Series

KEITH COUNTY--LIST OF MAPS AND THEIR AUTHORS Topography--U. S. Geological Survey Index of 7.5\u27 Topographic Quadrangles and Township Boundaries--R. F. Diffendal, Jr. Generalized Soils Map--M. Kuzila and J. Culver Approximate Loess Thickness--R. F. Diffendal, Jr. Bedrock Geologic Map--R. F. Diffendal, Jr. Volcanic Ash Localities--R. F. Diffendal, Jr. Ogallala Vertebrate Faunal Sites--R. F. Diffendal, Jr. Ogallala Group Outcrops--R. F. Diffendal, Jr. White River Group Outcrops--R. F. Diffendal, Jr. Conservation and Survey Division Test Hole Locations--R. F. Diffendal, Jr. Oil and/or Gas Test Hole Locations--R. F. Diffendal, Jr. Mineral Resources Localities--R. F. Diffendal, Jr. Locations of Registered Irrigation Wells--R. F. Diffendal, Jr. Configuration of Top of Bedrock--R. F. Diffendal, Jr. Configuration of Top of White River Group (= Brule Fm.)--R. F. Diffendal, Jr. Configuration of Top of Cretaceous--H. M. DeGraw Configuration of Top of Niobrara Fm.--H. M. DeGraw Configuration of Base of Greenhorn Limestone--H. M. DeGraw Configuration of Top of Permian System--R. R. Burchett Structural Contours on Top of Stone Corral--R. R. Burchett Structural Contours on Top of Pennsylvanian System--R. R. Burchett Depth to Precambrian Surface--M. P. Carlson Configuration of Top of Precambrian--R. R. Burchett and M. P. Carlson Geothermal Projected Temperatures on Top of Dakota Group--D. Eversoll and W. Gosnold Bouguer Gravity Anomaly Map--R. R. Burchett and T. Eversol

Keith County, Nebraska, Map Series

KEITH COUNTY--LIST OF MAPS AND THEIR AUTHORS Topography--U. S. Geological Survey Index of 7.5\u27 Topographic Quadrangles and Township Boundaries--R. F. Diffendal, Jr. Generalized Soils Map--M. Kuzila and J. Culver Approximate Loess Thickness--R. F. Diffendal, Jr. Bedrock Geologic Map--R. F. Diffendal, Jr. Volcanic Ash Localities--R. F. Diffendal, Jr. Ogallala Vertebrate Faunal Sites--R. F. Diffendal, Jr. Ogallala Group Outcrops--R. F. Diffendal, Jr. White River Group Outcrops--R. F. Diffendal, Jr. Conservation and Survey Division Test Hole Locations--R. F. Diffendal, Jr. Oil and/or Gas Test Hole Locations--R. F. Diffendal, Jr. Mineral Resources Localities--R. F. Diffendal, Jr. Locations of Registered Irrigation Wells--R. F. Diffendal, Jr. Configuration of Top of Bedrock--R. F. Diffendal, Jr. Configuration of Top of White River Group (= Brule Fm.)--R. F. Diffendal, Jr. Configuration of Top of Cretaceous--H. M. DeGraw Configuration of Top of Niobrara Fm.--H. M. DeGraw Configuration of Base of Greenhorn Limestone--H. M. DeGraw Configuration of Top of Permian System--R. R. Burchett Structural Contours on Top of Stone Corral--R. R. Burchett Structural Contours on Top of Pennsylvanian System--R. R. Burchett Depth to Precambrian Surface--M. P. Carlson Configuration of Top of Precambrian--R. R. Burchett and M. P. Carlson Geothermal Projected Temperatures on Top of Dakota Group--D. Eversoll and W. Gosnold Bouguer Gravity Anomaly Map--R. R. Burchett and T. Eversol

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

PDE4 is one of eleven known cyclic nucleotide phosphodiesterase families and plays a pivotal role in mediating hydrolytic degradation of the important cyclic nucleotide second messenger, cyclic 3′5′ adenosine monophosphate (cAMP). PDE4 inhibitors are known to have anti-inflammatory properties, but their use in the clinic has been hampered by mechanism-associated side effects that limit maximally tolerated doses. In an attempt to initiate the development of better-tolerated PDE4 inhibitors we have surveyed existing approved drugs for PDE4-inhibitory activity. With this objective, we utilised a high-throughput computational approach that identified moexipril, a well tolerated and safe angiotensin-converting enzyme (ACE) inhibitor, as a PDE4 inhibitor. Experimentally we showed that moexipril and two structurally related analogues acted in the micro molar range to inhibit PDE4 activity. Employing a FRET-based biosensor constructed from the nucleotide binding domain of the type 1 exchange protein activated by cAMP, EPAC1, we demonstrated that moexipril markedly potentiated the ability of forskolin to increase intracellular cAMP levels. Finally, we demonstrated that the PDE4 inhibitory effect of moexipril is functionally able to induce phosphorylation of the Hsp20 by cAMP dependent protein kinase A. Our data suggest that moexipril is a bona fide PDE4 inhibitor that may provide the starting point for development of novel PDE4 inhibitors with an improved therapeutic window

First observation of cyclotron radiation from MeV-scale epm{\rm e}^{pm} following nuclear beta decay

We present an apparatus for detection of cyclotron radiation that allows a frequency-based beta energy determination in the 5 keV to 5 MeV range, characteristic of nuclear beta decays. The cyclotron frequency of the radiating beta particles in a magnetic field is used to determine the beta energy precisely. Our work establishes the foundation to apply the cyclotron radiation emission spectroscopy (CRES) technique, developed by the Project 8 collaboration, far beyond the 18-keV tritium endpoint region. We report initial measurements of beta^-s from 6He and beta^+s from 19Ne decays to demonstrate the broadband response of our detection system and assess potential systematic uncertainties for beta spectroscopy over the full (MeV) energy range. This work is an important benchmark for the practical application of the CRES technique to a variety of nuclei, in particular, opening its reach to searches for evidence of new physics beyond the TeV scale via precision beta-decay measurements

EFFECTS OF HANDLING DISTURBANCE STRESS ON HEART RATE IN THE FERRUGINOUS HAWK BUTEO-REGALIS

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