Efficacy of endoluminal interventional therapy in diabetic peripheral arterial occlusive disease: a retrospective trial

<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to assess the efficacy of interventional therapy for peripheral arterial occlusive disease and the difference between diabetic patients and non-diabetic patients.</p> <p>Methods</p> <p>139 consecutive patients between September 2006 and September 2010 who underwent percutaneous lower extremity revascularization for arterial lesions were divided into diabetes group (n = 62) and non-diabetes group (n = 77). Before intervention, rest ankle brachial indexes and three dimensional computed tomography angiography from abdominal aorta to tiptoe were performed. The interventional treatments included angioplasty with or without stenting. The clinical outcomes included rest ankle-brachial indexes, primary patency rates, secondary patency rates and limb-salvage rates for 6-month, 12-month, 24-month and 36-month after treatment. The primary and secondary patency rates of all interventions and the limb-salvage rates of the patients are illustrated by Kaplan-Meier curves and compared by log-rank analysis.</p> <p>Results</p> <p>The interventional operation success rates were 98.4% (61/62) in diabetes group and 100% (77/77) in non-diabetes group. The re-interventional operation success rates were 85.7% (18/21) in diabetes group and 76.9% (20/26) in non-diabetes group. The mean value of ankle brachial indexes was significantly increased after intervention (0.397 ± 0.125 versus 0.779 ± 0.137, t = -25.780, <it>P </it>< 0.001) in diabetes group and (0.406 ± 0.101 versus 0.786 ± 0.121, t = -37.221, <it>P </it>< 0.001) in non-diabetes group. Perioperative 30-day mortality was 0%. Major complications included groin hematoma in 7.2%, and pseudoaneurysm formation 2.2%. In diabetes group, 6, 12, 24, and 36-month primary patency rates were 88.7% ± 4.0%, 62.3% ± 6.6%, 55.3% ± 7.0%, and 46.5% ± 7.5%; secondary patency rates were 93.5% ± 3.1%, 82.3% ± 5.1%, 70.8% ± 6.5%, and 65.7% ± 7%; limb-salvage rates were 95.2% ± 2.7%, 87.7% ± 4.4%, 85.5% ± 4.8%, and 81.9% ± 5.8%. In non-diabetes group, 6, 12, 24, and 36-month primary patency rates were 90.9% ± 3.3%, 71.8% ± 5.4%, 71.8% ± 5.4%, and 60.9% ± 6.2%; secondary patency rates were 96.1% ± 2.2%, 91.6% ± 3.3%, 82.7% ± 4.8%, and 71.8% ± 6.2%; limb-salvage rates were 97.4% ± 1.8%, 94.4% ± 2.7%, 90.6% ± 3.7%, and 83.1% ± 5.4%. The differences between two groups were not significant (<it>P </it>> 0.05).</p> <p>Conclusion</p> <p>With a low risk of morbidity and mortality, the percutaneous revascularization accepted by patients does not affect ultimate necessary surgical revascularization and consequently should be considered as the preferred therapy for chronic lower extremity ischemia. The efficacy and prognosis of interventional therapy in diabetic patients is similar that in non-diabetic patients.</p

Search Result Diversification in Short Text Streams

We consider the problem of search result diversification for streams of short texts. Diversifying search results in short text streams is more challenging than in the case of long documents, as it is difficult to capture the latent topics of short documents. To capture the changes of topics and the probabilities of documents for a given query at a specific time in a short text stream, we propose a dynamic Dirichlet multinomial mixture topic model, called D2M3, as well as a Gibbs sampling algorithm for the inference. We also propose a streaming diversification algorithm, SDA, that integrates the information captured by D2M3 with our proposed modified version of the PM-2 (Proportionality-based diversification Method -- second version) diversification algorithm. We conduct experiments on a Twitter dataset and find that SDA statistically significantly outperforms state-of-the-art non-streaming retrieval methods, plain streaming retrieval methods, as well as streaming diversification methods that use other dynamic topic models

Theoretical Analysis on Deflagration-to-Detonation Transition

The study on deflagration-to-detonation transition (DDT) is very important because this mechanism has relevance to safety issues in industries, where combustible premixed gases are in general use. However, the quantitative prediction of DDT is one of the major unsolved problems in combustion and detonation theory to date. In this paper, the DDT process is studied theoretically and the critical condition is given by a concise theoretical expression. The results show that a deflagration wave propagating with about 60% Chapman-Jouguet (C-J) detonation velocity is a critical condition. This velocity is the maximum propagating velocity of a deflagration wave and almost equal to the sound speed of combustion products. When this critical conation is reached, a C-J detonation is triggered immediately. This is the quantitative criteria of the DDT process

Seasonal distribution of active systemic lupus erythematosus and its correlation with meteorological factors

OBJECTIVE: To explore the characteristics of seasonal distribution of active systemic lupus erythematosus (SLE) and the influences of meteorological factors including temperature and humidity on active systemic lupus erythematosus. METHODS: The characteristics of seasonal distribution of active SLE and its correlation with meteorological factors were retrospectively analyzed in 640 patients living in the city of Zhanjiang, China and had active SLE between January 1997 and December 2006. RESULTS: In winter, when there are weaker ultraviolet (UV) rays, the ratio of patients with active SLE to total inpatients was 3.89 %o, which is significantly higher than in other seasons with stronger UV rays, including 2.17 %o in spring, 1.87 0 in summer and 2.12 0 in autumn. The number of patients with active SLE had significant negative correlation with mean temperature and was not significantly related to mean humidity. CONCLUSION: Active SLE has the characteristics of seasonal distribution and is associated with temperature. The mechanism remains to be further studied

Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery

Ligand-protein mapping was found to follow a power law and the preferential attachment principle, leading to the identification of the molecules, mostly nucleotide-containing compounds, that are likely to have evolved earliest

Suppression of Quantum Phase Interference in Molecular Magnets Fe&#8328; with Dipolar-Dipolar Interaction

Renormalized tunnel splitting with a finite distribution in the biaxial spin model for molecular magnets is obtained by taking into account the dipolar interaction of enviromental spins. Oscillation of the resonant tunnel splitting with a transverse magnetic field along the hard axis is smeared by the finite distribution which subsequently affects the quantum steps of hysteresis curve evaluated in terms of the modified Landau-Zener model of spin flipping induced by the sweeping field. We conclude that the dipolar-dipolar interaction drives decoherence of quantum tunnelling in molcular magnets Fe&#8328;, which explains why the quenching points of tunnel spliting between odd and even resonant tunnelling predcited theoretically were not observed experimentally.Comment: 5 pages including 3 figure and 1 table. To appear in Physical Review

Two-dimensional gapless spin liquids in frustrated SU(N) quantum magnets

A class of the symmetrically frustrated SU(N) models is constructed for quantum magnets based on the generators of SU(N) group. The total Hamiltonian lacks SU(N) symmtry. A mean field theory in the quasi-particle representation is developed for spin liquid states. Numerical solutions in two dimension indicate that the ground states are gapless and the quasi-particles are Dirac particles. The mechanism may be helpful in exploring the spin liquid phases in the spin-1 bilinear-biquadratic model and the spin-orbital model in higher dimensions.Comment: 9 pages, 3 figures, to appear in New Journal of Physic

Almost sure state estimation with H2-type performance constraints for nonlinear hybrid stochastic systems

This paper is concerned with the problem of almost sure state estimation for general nonlinear hybrid stochastic systems whose coefficients only satisfy local Lipschitz conditions. By utilizing the stopping time method combined with martingale inequalities, a theoretical framework is established for analyzing the so-called almost surely asymptotic stability of the addressed system. Within such a theoretical framework, some sufficient conditions are derived under which the estimation dynamics is almost sure asymptotically stable and the upper bound of estimation error is also determined. Furthermore, a suboptimal state estimator is obtained by solving an optimization problem in the H2 sense. According to the obtained results, for a class of special nonlinear hybrid stochastic systems, the corresponding conditions reduce to a set of matrix inequalities for the purpose of easy implementation. Finally, two numerical simulation examples are used to demonstrate the effectiveness of the results derived.This work was supported in part by the National Natural Science Foundation of China under Grants 61134009 and 61329301, the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany

The shallow-decay phase in both optical and x-ray afterglows of Swift GRB 090529A: Energy injection into a wind-type medium?

The energy injection model is usually proposed to interpret the shallow-decay phase in Swift GRB X-ray afterglows. However, very few GRBs have simultaneous signatures of energy injection in their optical and X-ray afterglows. Here, we report optical observations of GRB 090529A from 2000 sec to $\sim10^6$ sec after the burst, in which an achromatic decay is seen at both wavelengths. The optical light curve shows a decay from 0.37 to 0.99 with a break at $\sim10^5$ sec. In the same time interval, the decay indices of the X-ray light curve changed from 0.04 to 1.2. Comparing these values with the closure relations, the segment after 3$\times10^{4}$ sec is consistent with the prediction of the forward shock in an ISM medium without any energy injection. The shallow-decay phase between 2000 to 3$\times10^{4}$ sec could be due to the external shock in a wind-type-like medium with an energy injection under the condition of $\nu_o < \nu_c < \nu_x$. However, the constraint of the spectral region is not well consistent with the multi-band observations. For this shallow-decay phase, other models are also possible, such as energy injection with evolving microphysical parameters, or a jet viewed off-axis,etc.Comment: 19pages,2gigures, accepted by MNRA