Left ventricular heart failure and pulmonary hypertension

In patients with left ventricular heart failure (HF), the development of pulmonary hypertension (PH) and right ventricular (RV) dysfunction are frequent and have important impact on disease progression, morbidity, and mortality, and therefore warrant clinical attention. Pulmonary hypertension related to left heart disease (LHD) by far represents the most common form of PH, accounting for 65–80% of cases. The proper distinction between pulmonary arterial hypertension and PH-LHD may be challenging, yet it has direct therapeutic consequences. Despite recent advances in the pathophysiological understanding and clinical assessment, and adjustments in the haemodynamic definitions and classification of PH-LHD, the haemodynamic interrelations in combined post- and pre-capillary PH are complex, definitions and prognostic significance of haemodynamic variables characterizing the degree of pre-capillary PH in LHD remain suboptimal, and there are currently no evidence-based recommendations for the management of PH-LHD. Here, we highlight the prevalence and significance of PH and RV dysfunction in patients with both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), and provide insights into the complex pathophysiology of cardiopulmonary interaction in LHD, which may lead to the evolution from a ‘left ventricular phenotype’ to a ‘right ventricular phenotype’ across the natural history of HF. Furthermore, we propose to better define the individual phenotype of PH by integrating the clinical context, non-invasive assessment, and invasive haemodynamic variables in a structured diagnostic work-up. Finally, we challenge current definitions and diagnostic short falls, and discuss gaps in evidence, therapeutic options and the necessity for future developments in this context

The 18S ribosomal RNA sequence of the sea anemone <i>Ammonia sulcata</i> and its evolutionary position among other eukaryotes

Evolutionary trees based on partial small ribosomal subunit RNA sequences of 22 metazoa species have been published [(1988) Science 239, 748-753]. In these trees, cnidarians (Radiata) seemed to have evolved independently from the Bilateria, which is in contradiction with the general evolutionary view. In order to further investigate this problem, the complete srRNA sequence of the sea anemone Ammonia sulcata was determined and evolutionary trees were constructed using a matrix optimization method. In the tree thus obtained the sea anemone and Bilateria together form a monophyletic cluster, with the sea anemone forming the first line of descent of the metazoan group

Near-infrared follow-up to the May 2008 activation of SGR 1627-41

On 28 May 2008, the Swift satellite detected the first reactivation of SGR 1627-41 since its discovery in 1998. Following this event we began an observing campaign in near infrared wavelengths to search for a possible counterpart inside the error circle of this SGR, which is expected to show flaring activity simultaneous to the high energy flares or at least some variability as compared to the quiescent state. For the follow-up we used the 0.6m REM robotic telescope at La Silla Observatory, which allowed a fast response within 24 hours and, through director discretionary time, the 8.2m Very Large Telescope at Paranal Observatory. There, we observed with NACO to produce high angular resolution imaging with the aid of adaptive optics. These observations represent the fastest near infrared observations after an activation of this SGR and the deepest and highest spatial resolution observations of the Chandra error circle. 5 sources are detected in the immediate vicinity of the most precise X-ray localisation of this source. For 4 of them we do not detect variability, although the X-ray counterpart experimented a significant decay during our observation period. The 5th source is only detected in one epoch, where we have the best image quality, so no variability constrains can be imposed and remains as the only plausible counterpart. We can impose a limit of Ks > 21.6 magnitudes to any other counterpart candidate one week after the onset of the activity. Our adaptive optics imaging, with a resolution of 0.2" provides a reference frame for subsequent studies of future periods of activity.Comment: Accepted for publication in A&

The influence of home language and school language on the academic language proficiency of first-year students in higher education: an explorative study

Een colloquium over universitair taalvaardigheidsonderwijs Universiteit Leiden, 2 december 2016, the complete issue can be found at http://hdl.handle.net/1887/57204Wetensch. publicatieFaculteit der Geesteswetenschappe

Risk analysis of marine activities in the Belgian part of the North Sea (RAMA): final report

RAMA is a 2-year project (04/2004 - 04/2006) executed by two Belgian partners, Ecolas NV (Environmental Consultancy Agency) and the Maritime Institute (University of Ghent), and financed by the SPSD II research program, specific actions, of the Belgian Science Policy (BELPSO). RAMA aims to assess the environmental risks of spills by commercial shipping activities on the Belgian Part of the North Sea. Shipping patterns, transports of dangerous goods, probability of risks and the potential impact of spill incidents (oil & hazardous and noxious substances) will be assessed. The risk analysis within this project studies both the chances of a spill accident happening and the environmental impacts in case of an accident. The valorisation of the RAMA project will result in a thorough analysis of the current status of the shipping at the North Sea in relation to the issue of safety. The scope of the project will however go beyond the mere result of a fundamental risk analysis of the commercial shipping at the North Sea. It is also aiming at the formulation of recommendations to improve the safety level for the environment and at an optimization of response in the framework of the Belgian "North Sea Disaster Plan"

Equivalence of Kinetic Theories of Bose-Einstein Condensation

We discuss the equivalence of two non-equilibrium kinetic theories that describe the evolution of a dilute, Bose-Einstein condensed atomic gas in a harmonic trap. The second-order kinetic equations of Walser et al. [PRA 63, 013607 (2001)] reduce to the Gross-Pitaevskii equation and the quantum Boltzmann equation in the low and high temperature limits, respectively. These kinetic equations can thus describe the system in equilibrium (finite temperature) as well as in non-equilibrium (real time). We have found this theory to be equivalent to the non-equilibrium Green's function approach originally proposed by Kadanoff and Baym and more recently applied to inhomogeneous trapped systems by M. Imamovi\'c-Tomasovi\'c and A. Griffin [arXiv:cond-mat/9911402].Comment: REVTeX3, 6 pages, 2 eps figures, published version, minor change

Magnetic susceptibility of EuTe/PbTe Heisenberg superlattices: experimental and theoretical studies

We report results on the temperature dependence of the susceptibilities of a set of MBE-grown short-period EuTe/PbTe antiferromagnetic superlattices having different EuTe layer thicknesses. In-plane and orthogonal susceptibilities have been measured and display a strong anisotropy at low temperature, confirming the occurrence of a magnetic phase transition in the thicker samples, as seen also in neutron diffraction studies. We suggest that dipolar interactions stabilize antiferromagnetic long-range order in an otherwise isotropic system and we present numerical and analytical results for the low-temperature orthogonal susceptibility.Comment: 30 pages, 8 ps figures, RevTe

Study of the luminous blue variable star candidate G26.47+0.02 and its environment

The luminous blue variable (LBV) stars are peculiar very massive stars. The study of these stellar objects and their surroundings is important for understanding the evolution of massive stars and its effects on the interstellar medium. We study the LBV star candidate G26.47+0.02. Using several large-scale surveys in different frequencies we performed a multiwavelength study of G26.47+0.02 and its surroundings. We found a molecular shell (seen in the 13CO J=1-0 line) that partially surrounds the mid-infrared nebula of G26.47+0.02, which suggests an interaction between the strong stellar winds and the molecular gas. From the HI absorption and the molecular gas study we conclude that G26.47+0.02 is located at a distance of ~4.8 kpc. The radio continuum analysis shows a both thermal and non-thermal emission toward this LBV candidate, pointing to wind-wind collision shocks from a binary system. This hypothesis is supported by a search of near-IR sources and the Chandra X-ray analysis. Additional multiwavelength and long-term observations are needed to detect some possible variable behavior, and if that is found, to confirm the binary nature of the system.Comment: accepted in A&A 01/05/201

White Dwarf - Red Dwarf Systems Resolved with the Hubble Space Telescope: I. First Results

First results are presented for a Hubble Space Telescope Advanced Camera for Surveys snapshot study of white dwarfs with likely red dwarf companions. Of 48 targets observed and analyzed so far, 27 are totally or partially resolved into two or more components, while an additional 15 systems are almost certainly unresolved binaries. These results provide the first direct empirical evidence for a bimodal distribution of orbital separations among binary systems containing at least one white dwarf.Comment: 46 pages, 3 figures, 5 tables, accepted to ApJ. Full-resolution images available upon request. A few table entries correcte