599 research outputs found
Prevalência e fatores de risco para transtornos mentais comuns entre estudantes de medicina
The Worker Honeybee Fat Body Proteome Is Extensively Remodeled Preceding a Major Life-History Transition
Honeybee workers are essentially sterile female helpers that make up the majority of individuals in a colony. Workers display a marked change in physiology when they transition from in-nest tasks to foraging. Recent technological advances have made it possible to unravel the metabolic modifications associated with this transition. Previous studies have revealed extensive remodeling of brain, thorax, and hypopharyngeal gland biochemistry. However, data on changes in the abdomen is scarce. To narrow this gap we investigated the proteomic composition of abdominal tissue in the days typically preceding the onset of foraging in honeybee workers
Effect of cortisol levels on working memory performance in elderly subjects with Alzheimer's disease
Ticks infesting birds in Atlantic Forest fragments in Rio Claro, State of Sao Paulo, Brazil
Perfil sociossanitário e estilo de vida de hipertensos e/ou diabéticos, usuários do Programa de Saúde da Família no município de Teixeiras, MG
Use of Robson classification to assess cesarean section rate in Brazil: the role of source of payment for childbirth
Production, Composition, Fatty Acids Profile and Stability of Milk and Blood Composition of Dairy Cows Fed High Polyunsaturated Fatty Acids Diets and Sticky Coffee Hull
Instrument for evaluating care given by undergraduate nursing students to people with wounds
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10-8), 6q21 (rs9372120, P=9.09 × 10-15), 7q36.1 (rs7781265, P=9.71 × 10-9), 8q24.21 (rs1948915, P=4.20 × 10-11), 9p21.3 (rs2811710, P=1.72 × 10-13), 10p12.1 (rs2790457, P=1.77 × 10-8), 16q23.1 (rs7193541, P=5.00 × 10-12) and 20q13.13 (rs6066835, P=1.36 × 10-13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development
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