La descrizione del mondo. Reportage immaginari dalla città asiatica

Il volume elettronico raccoglie una selezione dei "reportage immaginari" elaborati negli anni 2011/12 e 2012/13 dagli studenti dell'atelier storia/progetto del Politecnico di Torino "Progettare la città asiatica", diretto da Michele Bonino e Filippo De Pieri. Con un'introduzione dei due curator

Time-dependent Gross-Pitaevskii equation for composite bosons as the strong-coupling limit of the fermionic BCS-RPA approximation

The linear response to a space- and time-dependent external disturbance of a system of dilute condensed composite bosons at zero temperature, as obtained from the linearized version of the time-dependent Gross-Pitaevskii equation, is shown to result also from the strong-coupling limit of the time-dependent BCS (or broken-symmetry RPA) approximation for the constituent fermions subject to the same external disturbance. In this way, it is possible to connect excited-state properties of the bosonic and fermionic systems by placing the Gross-Pitaevskii equation in perspective with the corresponding fermionic approximationsComment: 4 pages, 1 figur

Functional single nucleotide polymorphisms in dopaminergic receptors D2 predict clinical response to Cariprazine

Cariprazine (CAR) is an antipsychotic drug for the treatment of schizophrenia (SCZ) and bipolar disorder (BD), and it acts as a partial agonist on the dopamine receptors (DR), D2, and D3. Although many single nucleotide polymorphisms (SNPs) in genes coding for these receptors are known to influence response to antipsychotics, to date, no study on CAR pharmacogenetics exists. In this pilot study, we investigated the relationship between SNPs in DRD2 (rs1800497 and rs6277) and DRD3 (rs6280), and response to CAR treatment, evaluated by the psychometric Brief Psychiatric Rating Scale (BPRS), in a cohort of Caucasian patients. We found a significant association between DRD2 rs1800497 and rs6277 and response to CAR treatment. When genotypes were combined into an arbitrary score, the receiver operating characteristic curve analysis showed that using a cut-off value of -2.5 the response to CAR treatment could be predicted with a positive likelihood ratio of 8.0. Our study report, for the first time, a correlation between SNPs in DRD2 and response to CAR treatment. After confirmation in a larger cohort of patients, our results could open the way for the identification of new tools for the provision of response to CAR treatment

Effective interaction between molecules in the BEC regime of a superfluid Fermi gas

We investigate the effective interaction between Cooper-pair molecules in the st rong-coupling BEC regime of a superfluid Fermi gas with a Feshbach resonance. Our work uses a path integral formulation and a renormalization group (RG) analy sis of fluctuations in a single-channel model. We show that a physical cutoff en ergy $\omega_c$ originating from the finite molecular binding energy is the key to understanding the interaction between molecules in the BEC regime. Our work t hus clarifies recent results by showing that $a_{\rm M}=2a_{\rm F}$ is a {\it ba re} molecular scattering length while $a_{\rm M}=(0.6\sim0.75) a_{\rm F}$ is the low energy molecular scattering length renormalized to include high-energy scat tering up to $\omega_c$ (here $a_{\rm F}$ is the scattering length between Fermi atoms). We also include many-body effects at finite temperatures. We find that $a_{\rm M}$ is strongly dependent on temperature, vanishing at $T_{\rm c}$, consistent with the earlier Bose gas results of Bijlsma and Stoof.Comment: 10 pages, 3 figure

Integrating diffusion tensor imaging and neurite orientation dispersion and density imaging to improve the predictive capabilities of CED models

This paper aims to develop a comprehensive and subject-specific model to predict the drug reach in Convection-Enhanced Delivery (CED) interventions. To this end, we make use of an advance diffusion imaging technique, namely the Neurite Orientation Dispersion and Density Imaging (NODDI), to incorporate a more precise description of the brain microstructure into predictive computational models. The NODDI dataset is used to obtain a voxel-based quantification of the extracellular space volume fraction that we relate to the white matter (WM) permeability. Since the WM can be considered as a transversally isotropic porous medium, two equations, respectively for permeability parallel and perpendicular to the axons, are derived from a numerical analysis on a simplified geometrical model that reproduces flow through fibre bundles. This is followed by the simulation of the injection of a drug in a WM area of the brain and direct comparison of the outcomes of our results with a state-of-the-art model, which uses conventional diffusion tensor imaging. We demonstrate the relevance of the work by showing the impact of our newly derived permeability tensor on the predicted drug distribution, which differs significantly from the alternative model in terms of distribution shape, concentration profile and infusion linear penetration length

In Situ Treatment of Contaminated Water Environments: The Experiment of the Arsenale Vecchio, Venice Lagoon, Italy

We report on the results of an experiment of in situ bioremediation by forced aeration, carried out in the Arsenale Vecchio shipyard dock basin of the Venice Lagoon, Italy. The experimental area is characterized by its limited size and reduced boat traffic. The forced aeration technique chosen for the oxygenation of the highly polluted bottom sediments and of the water column above does not obstruct harbor activities and is unique due to its innovative use of a system of porous pipes laid on the bottom sediments. The general recovery of the polluted shipyard dock basin resulted in the documented return of small fish to the area as an indication of a less polluted environment. Most important the bioremediation of the water body above the bottom sediment favours, with time, the formation of a clean natural sediment capping over the bottom contaminated sediments. Post-experiment control after fifteen months of aeration with no extra oxygen added, shows the presence of clean light grey sediments with no foul septic smell, deposited over the polluted bottom sediments. The experiment has indicated that oxygenation by porous pipe forced aeration could represent a cost effective and environmentally feasible way for the recovery of shallow marine and fresh water systems, in situations where other techniques may not be economically and/or environmentally feasible

"La descrizione del mondo". Reportage immaginari dalla città asiatica

Il volume elettronico raccoglie una selezione dei "reportage immaginari" elaborati negli anni 2011/12 e 2012/13 dagli studenti dell'atelier storia/progetto del Politecnico di Torino "Progettare la città asiatica", diretto da Michele Bonino e Filippo De Pieri. Con un'introduzione dei due curator

Momentum distribution of a trapped Fermi gas with large scattering length

Using a scattering length parametrization of the BCS-BEC crossover as well as the local density approximation for the density profile, we calculate the momentum distribution of a harmonically trapped atomic Fermi gas at zero temperature. Various interaction regimes are considered, including the BCS phase, the unitarity limit and the molecular regime. We show that the relevant parameter which characterizes the crossover is given by the dimensionless combination $N^{1/6}a/a_{ho}$, where $N$ is the number of atoms, $a$ is the scattering length and $a_{ho}$ is the oscillator length. The width of the momentum distribution is shown to depend in a crucial way on the value and sign of this parameter. Our predictions can be relevant for experiments on ultracold atomic Fermi gases near a Feshbach resonance.Comment: 6 pages, 2 figures. Submitted to Phys. Rev. A. Added reference