RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Multi-messenger and transient astrophysics with the Cherenkov Telescope Array

The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators

Observation of the Gamma-Ray Binary HESS J0632+057 with the H.E.S.S., MAGIC, and VERITAS Telescopes

The results of gamma-ray observations of the binary system HESS J0632 + 057 collected during 450 hr over 15 yr, between 2004 and 2019, are presented. Data taken with the atmospheric Cherenkov telescopes H.E.S.S., MAGIC, and VERITAS at energies above 350 GeV were used together with observations at X-ray energies obtained with Swift-XRT, Chandra, XMM-Newton, NuSTAR, and Suzaku. Some of these observations were accompanied by measurements of the Hα emission line. A significant detection of the modulation of the very high-energy gamma-ray fluxes with a period of 316.7 ± 4.4 days is reported, consistent with the period of 317.3 ± 0.7 days obtained with a refined analysis of X-ray data. The analysis of data from four orbital cycles with dense observational coverage reveals short-timescale variability, with flux-decay timescales of less than 20 days at very high energies. Flux variations observed over a timescale of several years indicate orbit-to-orbit variability. The analysis confirms the previously reported correlation of X-ray and gamma-ray emission from the system at very high significance, but cannot find any correlation of optical Hα parameters with fluxes at X-ray or gamma-ray energies in simultaneous observations. The key finding is that the emission of HESS J0632 + 057 in the X-ray and gamma-ray energy bands is highly variable on different timescales. The ratio of gamma-ray to X-ray flux shows the equality or even dominance of the gamma-ray energy range. This wealth of new data is interpreted taking into account the insufficient knowledge of the ephemeris of the system, and discussed in the context of results reported on other gamma-ray binary systems