Evaluación de cepas de Escherichia coli productora de toxina shiga y Escherichia coli enteropatógena sometidas a condiciones de estrés en arena

Escherichia coli shigatoxigénico (STEC) y E. coli enteropatógeno (EPEC) constituyen patovares de E. coli que pueden causar diarrea infantil potencialmente mortal. Los objetivos del presente trabajo fueron: i) estudiar la persistencia de cepas STEC y EPEC en una matriz de arena sometida a condiciones ambientales estresantes (sequedad); ii) detectar la presencia de STEC y EPEC en areneros de jardines de infantes.Trabajo publicado en Cagliada, Maria del Pilar Lilia y Galosi, Cecilia Mónica (comps.). I Congreso de Microbiología Veterinaria. Libro de resúmenes. La Plata: Facultad de Ciencias Veterinarias, 2021.Facultad de Ciencias Veterinaria

Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study

Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms)

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Modelos de administración y gestión, políticas y metodologías, en materia de e-learning para la enseñanza en la universidad pública española

Proyecto elaborado en el ámbito de la 'III convocatoria de ayudas a la innovación educativa: convocatoria para el desarrollo y participación en proyectos de innovación educativa y mejora de la calidad docente, curso 2007-2008'No existe un modelo estándar, ni aproximaciones pedagógicas, tecnológicas u organizativas únicas al e-learning. Por ello es necesario determinar cuáles son los elementos que definen la elección de un modelo u otro para su aplicación al ámbito de la educación superior. En este sentido se ofrece una aproximación a los distintos modelos existentes de e-learning para, a continuación, realizar un estudio sobre el aprendizaje derivado del uso de estos modelos: aprendizaje significativo, aprendizaje basado en problemas, aprendizaje basado en proyectos, y aprendizaje basado en casos. Por último, se ofrece un apartado en el que se describe la situación del e-learning en la Universidad pública española, se proponen modelos de evaluación del e-learning y se dan herramientas para la acción docente y para la gestión de modelos en el ámbito universitario.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]