A Program Transformation for Continuation Call-Based Tabled Execution

The advantages of tabled evaluation regarding program termination and reduction of complexity are well known --as are the significant implementation, portability, and maintenance efforts that some proposals (especially those based on suspension) require. This implementation effort is reduced by program transformation-based continuation call techniques, at some efficiency cost. However, the traditional formulation of this proposal by Ramesh and Cheng limits the interleaving of tabled and non-tabled predicates and thus cannot be used as-is for arbitrary programs. In this paper we present a complete translation for the continuation call technique which, using the runtime support needed for the traditional proposal, solves these problems and makes it possible to execute arbitrary tabled programs. We present performance results which show that CCall offers a useful tradeoff that can be competitive with state-of-the-art implementations.Comment: Part of the proceedings of CICLOPS 200

The LcrG tip chaperone protein of the Yersinia pestis type III secretion system is partially folded

The type III secretion system (T3SS) is essential in the pathogenesis of Yersinia pestis, the causative agent of plague. A small protein, LcrG, functions as a chaperone to the tip protein LcrV, and the LcrG-LcrV interaction is important in regulating protein secretion through the T3SS. The atomic structure of the LcrG family is currently unknown. However, because of its predicted helical propensity, many have suggested that the LcrG family forms a coiled-coil structure. Here, we show by NMR and CD spectroscopy that LcrG lacks a tertiary structure and it consists of three partially folded alpha helices spanning residues 7-38, 41-46, and 58-73. NMR titrations of LcrG with LcrV show that the entire length of a truncated LcrG (residues 7-73) is involved in binding to LcrV. However, there is regional variation in how LcrG binds to LcrV. The C-terminal region of a truncated LcrG (residues 52-73) shows tight-binding interaction with LcrV while the N-terminal region (residues 7-51) shows weaker interaction with LcrV. This suggests there are at least two binding events when LcrG binds to LcrV. Biological assays and mutagenesis indicate that the C-terminal region of LcrG (residues 52-73) is important in blocking protein secretion through the T3SS. Our results reveal structural and mechanistic insights into the atomic conformation of LcrG and how it binds to LcrV

Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution

This is the publisher's version, also available electronically from http://scripts.iucr.org/cgi-bin/paper?S1744309113008579.The human pathogen Yersinia pestis requires the assembly of the type III secretion system (T3SS) for virulence. The structural component of the T3SS contains an external needle and a tip complex, which is formed by LcrV in Y. pestis. The structure of an LcrV triple mutant (K40A/D41A/K42A) in a C273S background has previously been reported to 2.2 Å resolution. Here, the crystal structure of LcrV without the triple mutation in a C273S background is reported at a higher resolution of 1.65 Å. Overall the two structures are similar, but there are also notable differences, particularly near the site of the triple mutation. The refined structure revealed a slight shift in the backbone positions of residues Gly28-Asn43 and displayed electron density in the loop region consisting of residues Ile46-Val63, which was disordered in the original structure. In addition, the helical turn region spanning residues Tyr77-Gln95 adopts a different orientation

When Fat Meets Disability in Poverty Porn: exploring the cultural mechanisms of suspicion in Too Fat to Work

There has been a distinct neglect of dis/ability in socio-cultural analysis of poverty porn (Runswick-Cole and Goodley 2015). This paper applies framing analysis to reality TV documentaries that feature larger bodied, disabled, welfare claimants to examine how cultural literacies of fatness and ‘obesity’ are drawn upon to cast suspicion upon disability welfare claimants in so-called poverty-porn. With a focus on Channel 5’s Benefit Britain series, Bene£its Too Fat to Work we demonstrate that enduring and harmful representations of 'obesity' are put to the work of securing public consent for a post-welfare society in the UK

The lived experiences of nuclear medicine technologists during Covid-19 pandemic

This study presented the lived experiences of the nuclear medicine technologists (NMTs) during the COVID-19 pandemic. The participants of this study are nuclear medicine technologists working in healthcare facilities before and during the COVID-19 pandemic. A qualitative research design was used, specifically the phenomenological qualitative approach. The participants were chosen through purposive and snowball sampling. Based on the findings, it can be concluded that the experiences of the NMTs is an interplay of fear, sadness, and happiness. Fear of contacting COVID and/or spreading it to others has become a driving force to be more mindful of the infection control measures, specifically on the use of PPEs and appropriate physical distancing measures. The sadness, happiness, and fear felt by the participants have seemed to balance and helped the participants to cope with the pandemic. There had been notable changes in the personal-social (isolation from family and friends) and professional (workload change, redeployment) lives of the participants. Adaptation to the changes brought about by the pandemic has been evident in the participants. These reflect the resilience of the participants in the midst of the pandemi

What patients see online: assessing the online identities of Pennsylvania dermatologists

Introduction: Patients use the internet to search for health-related information. We sought to characterize the information that patients find when searching for dermatologists on Google. Methods: The Centers for Medicare and Medicaid Services (CMS) Physician Comparable Downloadable File was utilized to identify all Medicare-participating dermatologists practicing in Pennsylvania (PA). A custom Google-based search engine was used to search each dermatologist. Up to the top 10 results for each physician were then sorted into: (1) physician, hospital, or healthcare system, (2) third-party, (3) social media, (4) academic journal articles, or (5) other. Results: Within the CMS, 519 health care providers (53.9% male, 46.1% female) self-identified as dermatologists practicing in PA. At least one search result was obtained for each physician (4,963 total search results). About 30.6% (1,519) search results were hospital, health system, or physician-controlled websites, and 26.6% (1,318) were third-party websites (1,318; 26.6%). Social media websites accounted for 601 (12.1%) hits whereas peer-reviewed academic journal websites generated 135 (2.7%) results. One-way chi-square analysis showed domains were not randomly distributed across the five categories (P<0.0001). Conclusion: Dermatologists should be better aware of their digital presence and the strategies to better control their online identity