Relaxation of Chemical Reactions to Stationary States in the Chemical Affinities Space

Using the mass balance equations for chemical reactions, we show how the system relaxes towards a steady state in and out of the Onsager region. In the chemical affinities space, after fast transients, the relaxation process is a straight line when operating in the Onsager region, while out of this regime, the evolution of the system is such that the projections of the evolution equations for the forces and the shortest path on the flows coincide. For spatially-extended systems, similar results are valid for the evolution of the thermodynamic mode (i.e., the mode with wave-number k = 0). These results allow us to obtain the expression for the affine connection of the space covered by the thermodynamic forces, close to the steady states. Through the affine connection, the nonlinear closure equations are derived.Comment: 23 pages

Ostial plication: a rarely reported cause of sudden death

We report a rare case of ostial plication as a potential cause of sudden death. Very few reports and images are available in the specialized literature regarding this anomaly. Ostial plication may be a source of sudden death or cause of death when no other significant autopsy findings are present

Sensitivity to wheat, gluten and FODMAPs in IBS: Facts or fiction?

IBS is one of the most common types of functional bowel disorder. Increasing attention has been paid to the causative role of food in IBS. Food ingestion precipitates or exacerbates symptoms, such as abdominal pain and bloating in patients with IBS through different hypothesised mechanisms including immune and mast cell activation, mechanoreceptor stimulation and chemosensory activation. Wheat is regarded as one of the most relevant IBS triggers, although which component(s) of this cereal is/are involved remain(s) unknown. Gluten, other wheat proteins, for example, amylase-trypsin inhibitors, and fructans (the latter belonging to fermentable oligo-di-mono-saccharides and polyols (FODMAPs)), have been identified as possible factors for symptom generation/exacerbation. This uncertainty on the true culprit(s) opened a scenario of semantic definitions favoured by the discordant results of double-blind placebo-controlled trials, which have generated various terms ranging from non-coeliac gluten sensitivity to the broader one of non-coeliac wheat or wheat protein sensitivity or, even, FODMAP sensitivity. The role of FODMAPs in eliciting the clinical picture of IBS goes further since these short-chain carbohydrates are found in many other dietary components, including vegetables and fruits. In this review, we assessed current literature in order to unravel whether gluten/wheat/FODMAP sensitivity represent 'facts' and not 'fiction' in IBS symptoms. This knowledge is expected to promote standardisation in dietary strategies (gluten/wheat-free and low FODMAP) as effective measures for the management of IBS symptoms

Long-term effects of automated mechanical peripheral stimulation on gait patterns of patients with Parkinson's disease

New treatments based on peripheral stimulation of the sensory–motor system have been inspiring new rehabilitation approaches in Parkinson’s disease (PD), especially to reduce gait impairment, levodopa washout effects, and the incidence of falls. The aim of this study was to evaluate the change in gait and the clinical status of PD patients after six sessions of a treatment based on automated mechanical peripheral stimulation (AMPS). Eighteen patients with PD and 15 age-matched healthy individuals (control group) participated in this study. A dedicated medical device delivered the AMPS. PD patients were treated with AMPS six times once every 4 days. All PD patients were treated in the off-levodopa phase and were evaluated with gait analysis before and after the first intervention (acute phase), after the sixth intervention, 48 h after the sixth intervention, and 10 days after the end of the treatment. To compare the differences among the AMPS interventions (pre, 6 AMPS, and 10 days) in terms of clinical scales, a t-test was used (α≤0.05). In addition, to compare the differences among the AMPS interventions (pre, post, 6 AMPS, 48 h and 10 days), the gait spatiotemporal parameters were analyzed using the Friedman test and the Bonferroni post-hoc test (α≤0.05). Also, for comparisons between the PD group and the control group, the gait spatiotemporal parameters were analyzed using the Mann–Whitney test and the Bonferroni post-hoc test (α≤0.05). The results of the study indicate that the AMPS treatment has a positive effect on bradykinesia because it improves walking velocity, has a positive effect on the step and stride length, and has a positive effect on walking stability, measured by the increase in stride length. These results are consistent with the improvements measured with clinical scales. These findings indicate that AMPS treatment seems to generate a more stable walking pattern in PD patients, reducing the well-known gait impairment that is typical of PD; regular repetition every 4 days of AMPS treatment appears to be able to improve gait parameters, to restore rhythmicity, and to reduce the risk of falls, with benefits maintained up to 10 days after the last treatment. The trial was registered online at ClinicalTrials.gov (number identifier: NCT0181528)

Acoustic charge transport in n-i-n three terminal device

We present an unconventional approach to realize acoustic charge transport devices that takes advantage from an original input region geometry in place of standard Ohmic input contacts. Our scheme is based on a n-i-n lateral junction as electron injector, an etched intrinsic channel, a standard Ohmic output contact and a pair of in-plane gates. We show that surface acoustic waves are able to pick up electrons from a current flowing through the n-i-n junction and steer them toward the output contact. Acoustic charge transport was studied as a function of the injector current and bias, the SAW power and at various temperatures. The possibility to modulate the acoustoelectric current by means of lateral in-plane gates is also discussed. The main advantage of our approach relies on the possibility to drive the n-i-n injector by means of both voltage or current sources, thus allowing to sample and process voltage and current signals as well.Comment: 9 pages, 3 figures. Submitted to Applied Physics Letter

Low cost alternatives to commercial lab kits for physics experiments

Conducting experiments in physics using modern measuring techniques, and particularly those utilizing computers, is often much more attractive to students than conducting experiments conventionally. However, the cost of professional kits in the Czech Republic is still very expensive for many schools. The basic equipment for one student workplace in the case of professional kits such as Vernier, Pasco or Coach costs around 800 euros. In this paper some physics experiments in which a computer, or a tablet with Microsoft Windows, is used as the measuring device, along with available physical devices such as a laser pointer, a solar cell or an electret microphone, are presented as suitable and alternative ways to carry out lab work. We show that it is possible to perform very simple school experiments (both as a central demonstration and as individual experimentation), in which high accuracy and clear final conclusions can be achieved at a very low cost. Further information is published on the specialized webpage www.sclpx.eu/ index.php?lang=en. The worksheets are in Czech, but the English version is in preparation

A Nonconvex Singular Stochastic Control Problem and its Related Optimal Stopping Boundaries

Abstract. Equivalences are known between problems of singular stochastic control (SSC) with convex performance criteria and related questions of optimal stopping; see, for example, Karatzas and Shreve [SIAM J. Control Optim., 22 (1984), pp. 856–877]. The aim of this paper is to inves-tigate how far connections of this type generalize to a nonconvex problem of purchasing electricity. Where the classical equivalence breaks down we provide alternative connections to optimal stopping problems. We consider a nonconvex infinite time horizon SSC problem whose state consists of an un-controlled diffusion representing a real-valued commodity price, and a controlled increasing bounded process representing an inventory. We analyze the geometry of the action and inaction regions by characterizing their (optimal) boundaries. Unlike the case of convex SSC problems we find that the optimal boundaries may be both reflecting and repelling and it is natural to interpret the problem as one of SSC with discretionary stopping

BioFET-SIM Web Interface: Implementation and Two Applications

We present a web interface for the BioFET-SIM program. The web interface allows to conveniently setup calculations based on the BioFET-SIM multiple charges model. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface

Effect of verbal instruction on motor learning ability of anaerobic and explosive exercises in physical education university students

This study investigated the effect of motor learning with informational feedback into response to anaerobic exercises with and without motor learning tasks in handball physical education university students. Participants were randomly divided into two groups: experimental group (EG, n = 10) and control group (CG, n = 10). Measurements of T-half test, 15-m and 30-m sprints, and ZIG-ZAG test were assessed in both groups before (T1), between (T2) a 4-week intervention program, and after (T3) an 8-week intervention program, which included agility and speed teaching with (EG) or without (CG) informational feedback (i.e., verbal instruction). The test-retest reliability for all tests was excellent, and the ICC ranged from 0.76 (ZIG-ZAG test) to 0.99 (Agility T test). The interday measurement error was clearly below 1% in all tests (CV range: 0.2–0.8). Time effects for the Agility T test (p = 0.012, η2p = 0.245) and the 15-m sprint (p = 0.035, η2p = 0.190) were found. For the Agility T test, a total interaction effect (p = 0.001, η2p = 0.380) and a partial interaction effect were calculated between T2 and T3 (p < 0.001, η2p = 0.603). A large effect size (d = 0.87) was observed in the EG from T2 to T3. The second relevant (d ≥ 0.5) effect size was calculated for the parameter sprint 30 m. The CG showed a significant sprint performance reduction from T2 to T3 (d = −0.60; parameter: sprint 30 m). All other effect sizes were less than 0.44. The ZIG-ZAG test revealed the largest main and partial effect sizes for all parameters. The EG showed the largest improvement (d = 2.00) between T2 and T3. The results demonstrate that motor learning with informational feedback improves performances of Agility T test, sprint, and ZIG-ZAG performance. It appears that a well-formulated verbal instruction may induce performance enhancement in young trainees in educational environment.The publication of this article was funded by the Qatar National Library. We thank Professor Mohamed Souhaiel Chelly [Research Unit (UR17JS01) “Sport Performance, Health & Society,” Higher Institute of Sport and Physical Education of Ksar Said, University of “La Manouba,” Tunisia] for his valuable experimental help