34 research outputs found

    Incubators as enablers for academic entrepreneurship

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    The key questions that academics are struggling with are: can one teach entrepreneurship and how can it be embedded into a science, technology or engineering curriculum while maintaining high academic standards. Furthermore, prior research has pointed to a mismatch between the competencies of the highest educated and most specialised students of our academic system and the expectations of the (corporate) market (Anseel, 2012; De Grande, De Boyser, Vandevelde et al, 2011). Therefore, this paper investigates the opportunities offered by 'learning-by-doing' in an ecosystem perspective. The organisation iMinds somehow acts as network integrator for research and entrepreneurship in ICT in Flanders. In this role, iMinds collaborates with universities and university colleges and other actors in the ecosystem supporting entrepreneurship. The various mechanisms deployed to support entrepreneurship and the development of entrepreneurial skills amongst (under) graduate students are analysed. These include extra-curricular activities (workshop and coaching series). Additionally, these activities are embedded in and intertwined with the development of entrepreneurial behaviour and skills in the classical curriculum using new learning methods. Some examples can be found at Karel de Grote University College (the so-called 'The Company' minor) and at Ghent University ('student-entrepreneur' status). The enabler to drive this evolution forward is the inclusion of incubators as part of the learning system. Students that want to start a business can spend 2 years on an MBA or join an incubator; the latter generally being accepted as a faster and more effective way of learning. Results can be seen at three levels. Firstly, it results in an increased awareness of entrepreneurship as viable career opportunity. Secondly, these programs increase the number of student start-ups, which additionally are better equipped to grow and prosper. Since the program's start in 2011, iMinds has received eight applications for student start-ups and has supported four. Furthermore, about 25 students have made use of the (physical) incubator space. Thirdly, this ecosystem approach results in an increased cooperation between universities (e.g., at the level of doctoral schools) and with other network actors, leading to spillover effects and more effective use of proceeds. The universities of the future will intertwine academic education with entrepreneurship. The end goal should not be that all students become entrepreneurs, but the development of entrepreneurial skills will be beneficial to all stakeholders. This requires collaboration with these stakeholders in the ecosystem, including incubators as further enablers of entrepreneurial behaviour

    Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors

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    Evaluation of kinetic parameters of drug-target binding, kon, koff, and residence time (RT), in addition to the traditional in vitro parameter of affinity is receiving increasing attention in the early stages of drug discovery. Target binding kinetics emerges as a meaningful concept for the evaluation of a ligand's duration of action and more generally drug efficacy and safety. We report the biological evaluation of a novel series of spirobenzo-oxazinepiperidinone derivatives as inhibitors of the human equilibrative nucleoside transporter 1 (hENT1, SLC29A1). The compounds were evaluated in radioligand binding experiments, i.e., displacement, competition association, and washout assays, to evaluate their affinity and binding kinetic parameters. We also linked these pharmacological parameters to the compounds' chemical characteristics, and learned that separate moieties of the molecules governed target affinity and binding kinetics. Among the 29 compounds tested, 28 stood out with high affinity and a long residence time of 87 min. These findings reveal the importance of supplementing affinity data with binding kinetics at transport proteins such as hENT1.Medicinal Chemistr

    Wages in high-tech start-ups - do academic spin-offs pay a wage premium?

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    Due to their origin from universities, academic spin‐offs operate at the forefront of the technological development. Therefore, spin‐offs exhibit a skill‐biased labour demand, i.e. spin‐offs have a high demand for employees with cutting edge knowledge and technical skills. In order to accommodate this demand, spin‐offs may have to pay a relative wage premium compared to other high‐tech start‐ups. However, neither a comprehensive theoretical assessment nor the empirical literature on wages in start‐ups unambiguously predicts the existence and the direction of wage differentials between spin‐offs and non‐spin‐offs. This paper addresses this research gap and examines empirically whether or not spin‐offs pay their employees a wage premium. Using a unique linked employer‐employee data set of German high‐tech start‐ups, we estimate Mincer‐type wage regressions applying the Hausman‐Taylor panel estimator. Our results show that spin‐offs do not pay a wage premium in general. However, a notable exception from this general result is that spin‐offs that commercialise new scientific results or methods provide higher wages to employees with linkages to the university sector – either as university graduates or as student workers

    Rowing against the wind: how do times of austerity shape academic entrepreneurship in unfriendly environments?

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    [EN] Academic spin-offs (ASOs) help universities transfer knowledge or technology through business projects developed by academic staff. This investigation aims at analyzing the critical factors for spin-off creation at universities operating in crisis-raven, entrepreneurship-unfriendly environments. Such factors revolve around four types of resources: environmental, institutional, organizational, and personal. Focusing on a Southern European context, as an example of an unfriendly environment affected by economic crisis, an entrepreneurial university (the Technical University of Valencia in Spain, UPV) is our research setting. Through a case study approach, we examine the potential of UPV as a springboard for ASOs. Our results show an adverse local environment, a rather favorable influence of institutional and organizational drivers, and a mixed role of personal factors. Our findings illustrate that UPV consistently supports spin-off creation due to a greater (rather positive) reflexivity from its institutional, organizational and personal resources than the (negative) imprinting of the unfriendly environment. This helps counter-balance the structural unfriendliness for academic entrepreneurship, and trigger a crisis-led risk-taking attitude by academic staff. Hence, UPV should continue with its current strategy of supporting academic entrepreneurship, and might transfer best practices to other universities also affected by unfavorable environmental conditions. Generally speaking, we would advise universities facing adverse circumstances to develop rules and mechanisms for academic entrepreneurship, carefully revise and improve malfunctions, and become involved throughout the whole process of spin-off development. All in all, our study advances understanding of how the different drivers for ASO creation can be revamped by universities located in unfriendly environments, having in mind the key role that universities play in fostering social and economic development through academic entrepreneurship in such environments.The authors would like to thank the Universitat Politecnica de Valencia (grant PAID-06-12-0916), and the Spanish Ministry of Economy and Competitiveness (grant ECO2011-29863), for their financial support for this research.Seguí-Mas, E.; Oltra, V.; Tormo-Carbó, G.; Sarrión Viñes, F. (2017). Rowing against the wind: how do times of austerity shape academic entrepreneurship in unfriendly environments?. International Entrepreneurship and Management Journal. 1-42. doi:10.1007/s11365-017-0478-zS142Acs, Z. J., Audretsch, D. B., & Lehmann, E. E. (2013). The knowledge spillover theory of entrepreneurship. Small Business Economics, 41, 757–774.Alemany, L. (2011). 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    HPLC determination of piperine in pepper and in pepper extracts

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    An economic evaluation of photovoltaic grid connected systems (PVGCS) in Flanders for companies: a generic model

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    Energy efficiency in buildings has become a key goal of any energy policy. Europe relies on the Energy Performance of Buildings Directive (EPBD), which has been converted by Flanders into the ‘Energy Performance and Interior Climate’ (EPB). Taking into account this Flemish EPB-standard (in terms of maximum U-values, E-level and K-value), this study seeks the economically most profitable combination of insulation - facade, roof, floor and glazing - for the Flemish citizen. For this purpose, a scenario-analysis is conducted using the EPB-software Flanders and a self-designed Excel file. Based on some important profitability criteria, the most profitable combination is determined for three representative types of dwellings studied. The scenario-analysis generates some well-founded guidelines for the Flemish citizen when building a house. It shows that in order to ensure the maximum profitability from investment in insulation, the key factor for the semi-detached dwelling is the insulation of roof and floor, whereas for a detached dwelling the key factor is the insulation of facade and floor. As a subsidiary consideration, the study also indicates that the U-values resulting from the more stringent E-level are still not sufficiently stringent because the U-values obtained for the most profitable combination are far below their maximum value. The same consideration applies in the case of the K-value.status: publishe
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