Observaciones sobre el proceso de conservación del cuerpo de la momia del Nevado del Chuscha

Fil: De Cicco, Carlos G.. Universidad Nacional de Cuy

Lower semicontinuity in GSBD for nonautonomous surface integrals

We provide a sufficient condition for lower semicontinuity of nonautonomous noncoercive surface energies defined on the space of $GSBD^p$ functions, whose dependence on the $x$-variable is $W^{1,1}$ or even $BV$: the notion of \emph{nonautonomous symmetric joint convexity}, which extends the analogous definition devised for autonomous integrands in \cite{FPS} where the conservativeness of the approximating vector fields is assumed. This condition allows to extend to our setting a nonautonomous chain formula in $SBV$ obtained in \cite{ACDD}, and this is a key tool in the proof of the lower semicontinuity result. This new joint convexity can be checked explicitly for some classes of surface energies arising from variational models of fractures in inhomogeneous materials

Restauración y conservación de una momia de altura : informe sobre control, tratamiento tanatopráxico parcial y tareas complementarias aplicadas a la "Momia Incaica del Cerro Aconcagua" (prov. Mendoza, Argentina)

En 2001 publicamos todas las investigaciones realizadas sobre el niño de 7 años ofrendado hace unos 500 años a las divinidades incaicas, hallado en 1985 en los flancos del cerro Aconcagua a 5.300 metros de altura. En la presente oportunidad se informa sobre un trabajo de carácter técnico efectuado en 2005 sobre esta momia (conservada en un freezer) con el fin de restaurarla, debido a que había quedado parcialmente dañada por efectos de la intervención practicada dos décadas antes con fines tanatológicos y de investigación biológica. Se detallan las sustancias utilizadas y los procedimientos -que consideramos novedosos y de valor metodológico que llevan a una restauración muy satisfactoria y contribuirá a la mejor conservación de este importante hallazgo antropológico.In 2001 we publish di the researches realized on the 7-year-oldchild ofrended approximately 500 years ago to the divinities incaicas, found in 1985 in the flanks of the hill Aconcagua to 5.300 meters of height. In the present opportunity it reports on a work of technical character effected in 2005 on this mummy (preserved in a freezer) in order to restore it, due to the fact that she had remained partially damaged by effects of the practised intervention two decades before with purposes tanatological and of biological research. The used substances and the procedures are detailed - that we consider to be new and of methodological value — that lead to a very satisfactory restoration and will contribute to the best conservation of this important anthropologic find.Fil: Allegretti, Pablo. Universidad Nacional de CuyoFil: De Cicco, Carlos G.. Universidad Nacional de CuyoFil: Schobinger, Juan. Universidad Nacional de Cuy

Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition

Olive tree leaves are an abundant source of bioactive compounds with several beneficial effects for human health, including a protective role against many types of cancer. In this study, we investigated the effect of an extract, obtained from olive tree (Olea europaea L.) leaves (OLE), on proliferation, invasion, and epithelial to mesenchymal transition (EMT) on metastatic melanoma, the highly aggressive form of skin cancer and the deadliest diseases. Our results demonstrated that OLE inhibited melanoma cells proliferation through cell cycle arrest and induction of apoptotic cell death. Moreover, OLE suppressed the migration, invasion, and colonies formation of human melanoma cells. Similar to our in vitro findings, we demonstrated that the oral administration of OLE inhibited cutaneous tumor growth and lung metastasis formation in vivo by modulating the expression of EMT related factors. In addition, the anti-proliferative and anti-invasive effects of OLE against melanoma were also related to a simultaneous targeting of mitogen-activated protein kinase and PI3K pathways, both in vitro and in vivo. In conclusion, our findings suggest that OLE has the potential to inhibit the metastatic spread of melanoma cells thanks to its multifaceted mechanistic effects, and may represent a new add-on therapy for the management of metastatic melanoma

New insights on metal allergy in total joint arthroplasty

Metal allergy is an uncommon and not completely understood cause of failure in total joint arthroplasty (TJA). However, either immunopathology neither histologic studies clarified the mechanisms through which the metal ions could lead to the complications related to them. The lack of evidence around this topic also reflects the difficulties to diagnose the MRP in TJA. In fact, the diagnosis is generally based on the exclusion of other causes. Currently, skin-patch testing and lymphocyte transformation test (LTT) are being commonly used to investigate about metal hypersensitivity and a delayed type-IV hypersensitivity is the immuno-histologic response to metals involved in TJA loosening. A review of the recent publications about this topic has been made focusing on immunology, histopathology, and clinics to better understand a still debated topic in orthopedic practice

Role of surgical setting and patients-related factors in predicting the occurrence of postoperative pulmonary complications after abdominal surgery

OBJECTIVE: The aim of this retrospective study was to evaluate the role of surgical setting (urgent vs. elective) and approach (open vs. laparoscopic) in affecting postoperative pulmonary complications (PPCs) prevalence in patients undergoing abdominal surgery. PATIENTS AND METHODS: After local Ethical Committee approval, 409 patients who had undergone abdominal surgery between January and December 2014 were included in the final analysis. PPCs were defined as the development of one of the following new findings: respiratory failure, pulmonary infection, aspiration pneumonia, pleural effusion, pneumothorax, atelectasis on chest X-ray, bronchospasm or un-planned urgent re-intubation. RESULTS: PPCs prevalence was greater in urgent (33%) vs. elective setting (7%) (chi(2) with Yates correction: 44; p=0.0001) and in open (6%) vs. laparoscopic approach (1.9%) (chi(2) with Yates correction: 12; p=0.0006). PPCs occurrence was positively correlated with in-hospital mortality (Biserial Correlation r=0.37; p=0.0001). Logistic regression showed that urgent setting (p=0.000), Ariscat (Assess Respiratory Risk in Surgical Patients in Catalonia) score (p=0.004), and age (p=0.01) were predictors of PPCs. A cutoff of 23 for Ariscat score was also identified as determining factor for PPCs occurrence with 94% sensitivity and 29% specificity. CONCLUSIONS: Patients undergoing abdominal surgery in an urgent setting were exposed to a higher risk of PPCs compared to patients scheduled for elective procedures. Ariscat score fitted with PPCs prevalence and older patients were exposed to a higher risk of PPCs. Prospective studies are needed to confirm these result

The VOICE Survey : VST Optical Imaging of the CDFS and ES1 Fields

Indexación: Scopus.We present the VST Optical Imaging of the CDFS and ES1 Fields (VOICE) Survey, a VST INAF Guaranteed Time program designed to provide optical coverage of two 4 deg2 cosmic windows in the Southern hemisphere. VOICE provides the first, multi-band deep optical imaging of these sky regions, thus complementing and enhancing the rich legacy of longer-wavelength surveys with VISTA, Spitzer, Herschel and ATCA available in these areas and paving the way for upcoming observations with facilities such as the LSST, MeerKAT and the SKA. VOICE exploits VST's OmegaCAM optical imaging capabilities and completes the reduction of WFI data available within the ES1 fields as part of the ESO-Spitzer Imaging Extragalactic Survey (ESIS) program providing ugri and uBVR coverage of 4 and 4 deg2 areas within the CDFS and ES1 field respectively. We present the survey's science rationale and observing strategy, the data reduction and multi-wavelength data fusion pipeline. Survey data products and their future updates will be released at http://www.mattiavaccari.net/voice/ and on CDS/VizieR.https://pos.sissa.it/275/026/pd

SUDARE-VOICE variability-selection of Active Galaxies in the Chandra Deep Field South and the SERVS/SWIRE region

One of the most peculiar characteristics of Active Galactic Nuclei (AGN) is their variability over all wavelengths. This property has been used in the past to select AGN samples and is foreseen to be one of the detection techniques applied in future multi-epoch surveys, complementing photometric and spectroscopic methods. In this paper, we aim to construct and characterise an AGN sample using a multi-epoch dataset in the r band from the SUDARE-VOICE survey. Our work makes use of the VST monitoring program of an area surrounding the Chandra Deep Field South to select variable sources. We use data spanning a six month period over an area of 2 square degrees, to identify AGN based on their photometric variability. The selected sample includes 175 AGN candidates with magnitude r < 23 mag. We distinguish different classes of variable sources through their lightcurves, as well as X-ray, spectroscopic, SED, optical and IR information overlapping with our survey. We find that 12% of the sample (21/175) is represented by SN. Of the remaining sources, 4% (6/154) are stars, while 66% (102/154) are likely AGNs based on the available diagnostics. We estimate an upper limit to the contamination of the variability selected AGN sample of about 34%, but we point out that restricting the analysis to the sources with available multi-wavelength ancillary information, the purity of our sample is close to 80% (102 AGN out of 128 non-SN sources with multi-wavelength diagnostics). Our work thus confirms the efficiency of the variability selection method in agreement with our previous work on the COSMOS field; in addition we show that the variability approach is roughly consistent with the infrared selection.Comment: Published in A & A, 15 pages, 6 figure

Integrated Nitrogen CAtchment model (INCA) applied to a tropical catchment in the Atlantic Forest, São Paulo, Brazil

International audienceStream-water flows and in-stream nitrate and ammonium concentrations in a small (36.7 ha) Atlantic Forest catchment were simulated using the Integrated Nitrogen in CAtchments (INCA) model version 1.9.4. The catchment, at Cunha, is in the Serra do Mar State Park, SE Brazil and is nearly pristine because the nearest major conurbations, São Paulo and Rio, are some 450 km distant. However, intensive farming may increase nitrogen (N) deposition and there are growing pressures for urbanisation. The mean-monthly discharges and NO3-N concentration dynamics were simulated adequately for the calibration and validation periods with (simulated) loss rates of 6.55 kg.ha?1 yr?1 for NO3-N and 3.85 kg.ha?1 yr?1 for NH4-N. To investigate the effects of elevated levels of N deposition in the future, various scenarios for atmospheric deposition were simulated; the highest value corresponded to that in a highly polluted area of Atlantic Forest in Sao Paulo City. It was found that doubling the atmospheric deposition generated a 25% increase in the N leaching rate, while at levels approaching the highly polluted São Paulo deposition rate, five times higher than the current rate, leaching increased by 240%, which would create highly eutrophic conditions, detrimental to downstream water quality. The results indicate that the INCA model can be useful for estimating N concentration and fluxes for different atmospheric deposition rates and hydrological conditions

Optically variable active galactic nuclei in the 3 yr VST survey of the COSMOS field

The analysis of the variability of active galactic nuclei (AGNs) at different wavelengths and the study of possible correlations among different spectral windows are nowadays a major field of inquiry. Optical variability has been largely used to identify AGNs in multivisit surveys. The strength of a selection based on optical variability lies in the chance to analyze data from surveys of large sky areas by ground-based telescopes. However the effectiveness of optical variability selection, with respect to other multiwavelength techniques, has been poorly studied down to the depth expected from next generation surveys. Here we present the results of our r-band analysis of a sample of 299 optically variable AGN candidates in the VST survey of the COSMOS field, counting 54 visits spread over three observing seasons spanning > 3 yr. This dataset is > 3 times larger in size than the one presented in our previous analysis (De Cicco et al. 2015), and the observing baseline is ~8 times longer. We push towards deeper magnitudes (r(AB) ~23.5 mag) compared to past studies; we make wide use of ancillary multiwavelength catalogs in order to confirm the nature of our AGN candidates, and constrain the accuracy of the method based on spectroscopic and photometric diagnostics. We also perform tests aimed at assessing the relevance of dense sampling in view of future wide-field surveys. We demonstrate that the method allows the selection of high-purity (> 86%) samples. We take advantage of the longer observing baseline to achieve great improvement in the completeness of our sample with respect to X-ray and spectroscopically confirmed samples of AGNs (59%, vs. ~15% in our previous work), as well as in the completeness of unobscured and obscured AGNs. The effectiveness of the method confirms the importance to develop future, more refined techniques for the automated analysis of larger datasets.Comment: 21 pages, 10 figures; accepted for publication in A&