Cepheid Mass-loss and the Pulsation -- Evolutionary Mass Discrepancy

I investigate the discrepancy between the evolution and pulsation masses for Cepheid variables. A number of recent works have proposed that non-canonical mass-loss can account for the mass discrepancy. This mass-loss would be such that a 5Mo star loses approximately 20% of its mass by arriving at the Cepheid instability strip; a 14Mo star, none. Such findings would pose a serious challenge to our understanding of mass-loss. I revisit these results in light of the Padova stellar evolutionary models and find evolutionary masses are ($17\pm5$)% greater than pulsation masses for Cepheids between 5<M/Mo<14. I find that mild internal mixing in the main-sequence progenitor of the Cepheid are able to account for this mass discrepancy.Comment: 15 pages, 3 figures, ApJ accepte

A phase Ib study of pertuzumab, a recombinant humanised antibody to HER2, and docetaxel in patients with advanced solid tumours

Pertuzumab represents the first in a new class of targeted therapeutics known as HER dimerisation inhibitors. We conducted a phase Ib study to determine the maximum-tolerated dose, the dose limiting toxicities (DLT), and pharmacokinetic (PK) interaction of docetaxel when administered in combination with pertuzumab. Initially, two dose levels of docetaxel (60 and 75 mg m−2) were explored in combination with a fixed dose of 1050 mg of pertuzumab; then two dose levels of docetaxel (75 and 100 mg m−2) were explored in combination following a fixed dose of 420 mg of pertuzumab with a loading dose of 840 mg. Both drugs were administered intravenously every 3 weeks. The latter dose of pertuzumab was allowed after an amendment to the original protocol when phase II data suggesting no difference in toxicity or activity between the 2 doses became available. Two patients out of two treated at docetaxel 75 mg m−2 in combination with pertuzumab 1050 mg suffered DLT (grade 3 diarrhoea and grade 4 febrile neutropaenia). Two out of five patients treated at docetaxel 100 mg m−2 in combination with pertuzumab 420 mg with a loading dose of 840 mg suffered DLT (grade 3 fatigue and grade 4 febrile neutropaenia). Stable disease was observed at four cycles in more than half of the patients treated and a confirmed radiological partial response with a >50% decline in PSA in a patient with hormone refractory prostate cancer were observed. There were no pharmacokinetic drug–drug interactions. The recommended phase II dose of this combination was docetaxel 75 mg m−2 and 420 mg pertuzumab following a loading dose of 840 mg

On the metallicity gradient of the Galactic disk

Aims: The iron abundance gradient in the Galactic stellar disk provides fundamental constraints on the chemical evolution of this important Galaxy component. However the spread around the mean slope is, at fixed Galactocentric distance, larger than estimated uncertainties. Methods: To provide quantitative constraints on these trends we adopted iron abundances for 265 classical Cepheids (more than 50% of the currently known sample) based either on high-resolution spectra or on photometric metallicity indices. Homogeneous distances were estimated using near-infrared Period-Luminosity relations. The sample covers the four disk quadrants and their Galactocentric distances range from ~5 to ~17 kpc. Results: A linear regression over the entire sample provides an iron gradient of -0.051+/-0.004 dex/kpc. The above slope agrees quite well, within the errors, with previous estimates based either on Cepheids or on open clusters covering similar Galactocentric distances. However, once we split the sample in inner (Rg < 8 kpc) and outer disk Cepheids we found that the slope (-0.130+/-0.015 dex/kpc) in the former region is ~3 times steeper than the slope in the latter one (-0.042+/-0.004 dex/kpc). We found that in the outer disk the radial distribution of metal-poor (MP, [Fe/H]<-0.02 dex) and metal-rich (MR) Cepheids across the four disk quadrants does not show a clear trend when moving from the innermost to the external disk regions. We also found that the relative fractions of MP and MR Cepheids in the 1st and in the 3rd quadrant differ at 8 sigma (MP) and 15 sigma (MR) level.Comment: 6 pages, 6 figures, A&A accepte

Constraints on the Formation of the Globular Cluster IC 4499 from Multi-Wavelength Photometry

We present new multiband photometry for the Galactic globular cluster IC 4499 extending well past the main sequence turn-off in the U, B, V, R, I, and DDO51 bands. This photometry is used to determine that IC4499 has an age of 12 pm 1 Gyr and a cluster reddening of E(B-V) = 0.22 pm 0.02. Hence, IC 4499 is coeval with the majority of Galactic GCs, in contrast to suggestions of a younger age. The density profile of the cluster is observed to not flatten out to at least r~800 arcsec, implying that either the tidal radius of this cluster is larger than previously estimated, or that IC 4499 is surrounded by a halo. Unlike the situation in some other, more massive, globular clusters, no anomalous color spreads in the UV are detected among the red giant branch stars. The small uncertainties in our photometry should allow the detection of such signatures apparently associated with variations of light elements within the cluster, suggesting that IC 4499 consists of a single stellar population.Comment: accepted to MNRA

Spotting the diffusion of New Psychoactive Substances over the Internet

Online availability and diffusion of New Psychoactive Substances (NPS) represent an emerging threat to healthcare systems. In this work, we analyse drugs forums, online shops, and Twitter. By mining the data from these sources, it is possible to understand the dynamics of drugs diffusion and their endorsement, as well as timely detecting new substances. We propose a set of visual analytics tools to support analysts in tackling NPS spreading and provide a better insight about drugs market and analysis

The VMC Survey. V. First results for Classical Cepheids

The VISTA Magellanic Cloud (VMC, PI M.R. Cioni) survey is collecting deep Ks-band time-series photometry of the pulsating variable stars hosted by the system formed by the two Magellanic Clouds (MCs) and the "bridge" connecting them. In this paper we present the first results for Classical Cepheids, from the VMC observations of two fields in the Large Magellanic Cloud (LMC). The VMC Ks-band light curves of the Cepheids are well sampled (12-epochs) and of excellent precision. We were able to measure for the first time the Ks magnitude of the faintest Classical Cepheids in the LMC (Ks\sim17.5 mag), which are mostly pulsating in the First Overtone (FO) mode, and to obtain FO Period-Luminosity (PL), Period-Wesenheit (PW), and Period-Luminosity-Color (PLC) relations, spanning the full period range from 0.25 to 6 day. Since the longest period Cepheid in our dataset has a variability period of 23 day, we have complemented our sample with literature data for brighter F Cepheids. On this basis we have built a PL relation in the Ks band that, for the first time, includes short period pulsators, and spans the whole range from 1.6 to 100 days in period. We also provide the first ever empirical PW and PLC relations using the (V-Ks) color and time-series Ks photometry. The very small dispersion (\sim0.07 mag) of these relations makes them very well suited to study the three-dimensional (3D) geometry of the Magellanic system. The use of "direct" (parallax- and Baade-Wesselink- based) distance measurements to both Galactic and LMC Cepheids, allowed us to calibrate the zero points of the PL, PW, and PLC relations obtained in this paper, and in turn to estimate an absolute distance modulus of (m-M)0=18.46\pm0.03 for the LMC. This result is in agreement with most of the latest literature determinations based on Classical Cepheids.Comment: 12 pages, 7 figures: MNRAS in pres