10 research outputs found
Multi-site, Multi-domain Airway Tree Modeling (ATM'22): A Public Benchmark for Pulmonary Airway Segmentation
Open international challenges are becoming the de facto standard for
assessing computer vision and image analysis algorithms. In recent years, new
methods have extended the reach of pulmonary airway segmentation that is closer
to the limit of image resolution. Since EXACT'09 pulmonary airway segmentation,
limited effort has been directed to quantitative comparison of newly emerged
algorithms driven by the maturity of deep learning based approaches and
clinical drive for resolving finer details of distal airways for early
intervention of pulmonary diseases. Thus far, public annotated datasets are
extremely limited, hindering the development of data-driven methods and
detailed performance evaluation of new algorithms. To provide a benchmark for
the medical imaging community, we organized the Multi-site, Multi-domain Airway
Tree Modeling (ATM'22), which was held as an official challenge event during
the MICCAI 2022 conference. ATM'22 provides large-scale CT scans with detailed
pulmonary airway annotation, including 500 CT scans (300 for training, 50 for
validation, and 150 for testing). The dataset was collected from different
sites and it further included a portion of noisy COVID-19 CTs with ground-glass
opacity and consolidation. Twenty-three teams participated in the entire phase
of the challenge and the algorithms for the top ten teams are reviewed in this
paper. Quantitative and qualitative results revealed that deep learning models
embedded with the topological continuity enhancement achieved superior
performance in general. ATM'22 challenge holds as an open-call design, the
training data and the gold standard evaluation are available upon successful
registration via its homepage.Comment: 32 pages, 16 figures. Homepage: https://atm22.grand-challenge.org/.
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The art of Linux kernel design : illustrating the operating system design principle and implementation
circ-Amotl1 in extracellular vesicles derived from ADSCs improves wound healing by upregulating SPARC translation
Aim: This study aims to explore the mechanism of circ- AMOT-like protein 1 (Amotl1) in extracellular vesicles (Evs) derived from adipose-derived stromal cells (ADSCs) regulating SPARC translation in wound healing process. Methods: The morphology, wound healing rate of the wounds and Ki67 positive rate in mouse wound healing models were assessed by H&E staining and immunohistochemistry (IHC). The binding of IGF2BP2 and SPARC was verified by RNA pull-down. Adipose-derived stromal cells (ADSCs) were isolated and verified. The Evs from ADSCs (ADSC-Evs) were analyzed. Results: Overexpression of SPARC can promote the wound healing process in mouse models. IGF2BP2 can elevate SPARC expression to promote the proliferation and migration of HSFs. circ-Amotl1 in ADSC-Evs can increase SPARC expression by binding IGF2BP2 to promote the proliferation and migration of HSFs. Conclusion: ADSC-Evs derived circ-Amotl1 can bind IGF2BP2 to increase SPARC expression and further promote wound healing process
Multi-site, Multi-domain Airway Tree Modeling
Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolution. Since EXACTâ09 pulmonary airway segmentation, limited effort has been directed to the quantitative comparison of newly emerged algorithms driven by the maturity of deep learning based approaches and extensive clinical efforts for resolving finer details of distal airways for early intervention of pulmonary diseases. Thus far, public annotated datasets are extremely limited, hindering the development of data-driven methods and detailed performance evaluation of new algorithms. To provide a benchmark for the medical imaging community, we organized the Multi-site, Multi-domain Airway Tree Modeling (ATMâ22), which was held as an official challenge event during the MICCAI 2022 conference. ATMâ22 provides large-scale CT scans with detailed pulmonary airway annotation, including 500 CT scans (300 for training, 50 for validation, and 150 for testing). The dataset was collected from different sites and it further included a portion of noisy COVID-19 CTs with ground-glass opacity and consolidation. Twenty-three teams participated in the entire phase of the challenge and the algorithms for the top ten teams are reviewed in this paper. Both quantitative and qualitative results revealed that deep learning models embedded with the topological continuity enhancement achieved superior performance in general. ATMâ22 challenge holds as an open-call design, the training data and the gold standard evaluation are available upon successful registration via its homepage (https://atm22.grand-challenge.org/)