Magnetic properties and quench dynamics of two interacting ultracold molecules in a trap

We theoretically investigate the magnetic properties and nonequilibrium dynamics of two interacting ultracold polar and paramagnetic molecules in a one-dimensional harmonic trap in external electric and magnetic fields. The molecules interact via a multichannel two-body contact potential, incorporating the short-range anisotropy of intermolecular interactions. We show that various magnetization states arise from the interplay of the molecular interactions, electronic spins, dipole moments, rotational structures, external fields, and spin-rotation coupling. The rich magnetization diagrams depend primarily on the anisotropy of the intermolecular interaction and the spin-rotation coupling. These specific molecular properties are challenging to calculate or measure. Therefore, we propose the quench dynamics experiments for extracting them from observing the time evolution of the analyzed system. Our results indicate the possibility of controlling the molecular few-body magnetization with the external electric field and pave the way towards studying the magnetization of ultracold molecules trapped in optical tweezers or optical lattices and their application in quantum simulation of molecular multichannel many-body Hamiltonians and quantum information storing.Comment: 16 pages, 8 figures, the code is available at https://github.com/Shmoo137/Two-Molecules-1D-Tra

Rola samorządu lokalnego i branży turystycznej w kształtowaniu systemu informacji turystycznej na przykładzie województwa zachodniopomorskiego

Celem niniejszego opracowania jest pokazanie, w kontekście wyników przeprowadzonych badań  w województwie zachodniopomorskim,  że wykreowanie sprawnie funkcjonującego systemu informacji turystycznej wymaga aktywnej współpracy samorządu lokalnego z branżą turystyczną. 

Social campaigns as a possibilities to build cooperation sports organizations with business organizations. Actions embedded in the CSR concept

The aim of the article is to indicate the possibility of joint action in the strategic CSR-profit organizations (min. Company) and non-profit (min. Sports clubs). The authors point to social campaigns as one of the possibilities, which allows for the creation of joint business-social projects, with particular focus on the context of CSR and the 7th ISO 26000 area; the involvement and development of local communities

Multifunctional Ligand Approach : search for Effective Therapy Against Alzheimers Disease

Alzheimer’s disease is a progressive, incurable, and complex neurodegenerative disease. Currently, an effective treatment that can slow down or stop the damage and death of neurons, which is a characteristic of Alzheimer’s disease, is lacking. Taking into account the complex nature of the disease, a multitarget design approach has been developed for the production of new potential anti-AD agents. The goal of this approach is to create a single molecule that can interact selectively with several desired molecular targets relevant to the disease. This strategy was successfully developed two decades ago and has been improved in recent years. This chapter describes the progress made in the discovery and design of selected multitargeted drugs based on molecular targets, which can be used for treating Alzheimer’s disease. The most promising among these drugs are the molecules having properties that are valuable not only in the symptomatic therapy but also in the causal treatment of the disease. The main hypotheses of Alzheimer’s disease, such as β-amyloid (Aβ), tau, and cholinergic, suggest that compounds capable of inhibiting the aggregation of neurotoxic Aβ amyloid peptide and tau protein, and improving the cholinergic neurotransmission, may possess such properties. Examples of such multifunctional molecules, which have been recently reported in the literature, are presented in this chapter

Dermal exposure to immunostimulants induces changes in activity and proliferation of coelomocytes of Eisenia andrei

Due to the specific habitat conditions in which they live, earthworms are constantly exposed to pathogens. Consequently, they have evolved various immuno-defense mechanisms, including cellular (coelomocytes) and humoral responses, which may help to eliminate deleterious micro-organisms but also repair and/or protect host cells and tissues. Similar to mammalian phagocytes, coelomocytes can kill ingested pathogens with reactive oxygen species (ROS) and nitric oxide. In the present work, we studied the effects of the dermal exposure of Eisenia andrei earthworms to different immuno-stimulants: phorbol-12-myristate-13-acetate (PMA), lipopolysaccharide (LPS) or concanavalin A (ConA). After 3 days of treatment with all immuno-stimulants, decreased numbers and changed composition of the coelomocytes were observed. The immuno-stimulants also induced numerous changes in bactericidal activity, including ROS production. Furthermore, all stimulants increased cell proliferation while only LPS-treatment significantly elevated apoptosis of coelomocytes. These results demonstrate that in vivo treatment of earthworms with immuno-stimulants induces various changes in their coelomocyte response

Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease

Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder. The available therapy is limited to the symptomatic treatment and its efficacy remains unsatisfactory. In view of the prevalence and expected increase in the incidence of AD, the development of an effective therapy is crucial for public health. Due to the multifactorial aetiology of this disease, the multi-target-directed ligand (MTDL) approach is a promising method in search for new drugs for AD. This review updates information on the development of multifunctional potential anti-AD agents published within the last three years. The majority of the recently reported structures are acetylcholinesterase inhibitors, often endowed with some additional properties. These properties enrich the pharmacological profile of the compounds giving hope for not only symptomatic but also causal treatment of the disease. Among these advantageous properties, the most often reported are an amyloid- antiaggregation activity, inhibition of -secretase and monoamine oxidase, an antioxidant and metal chelating activity, NOreleasing ability and interaction with cannabinoid, NMDA or histamine H3 receptors. The majority of novel molecules possess heterodimeric structures, able to interact with multiple targets by combining different pharmacophores, original or derived from natural products or existing therapeutics (tacrine, donepezil, galantamine, memantine). Among the described compounds, several seem to be promising drug candidates, while others may serve as a valuable inspiration in the search for new effective therapies for AD

Lipofuscin-mediated photodynamic stress induces adverse changes in nanomechanical properties of retinal pigment epithelium cells

Abstract Retinal pigment epithelium (RPE) is an important part of the blood-retina barrier (BRB) that separates the retina from the choroid. Although melanin granules contribute to the mechanical stability of the BRB complex, it is unknown if the age pigment lipofuscin affects mechanical properties of the tissue. To address this issue the effect of sub-lethal photic stress mediated by phagocytized lipofuscin granules, isolated from RPE of human donors, on morphology and mechanical properties of ARPE-19 cells was investigated. Nanomechanical analysis using atomic force spectroscopy revealed that irradiation of cells containing lipofuscin granules with blue light induced significant softening of the cells, which was accompanied by substantial reorganization of the cell cytoskeleton due to peroxidation of cellular proteins. Our results indicate that lipofuscin-mediated photic stress can cause significant modification of the RPE cells with the potential to disturb biological function of the BRB complex

Zamówienia publiczne na innowacje

The Author deals with public procurement of innovation (PPI and PCP) introducing the meaning of this legal institution, presenting and explaining it. This goals are achieved by indicating its characteristic features, as well as paying attention to the role they play in the economic turnover, and the expectations of the European Union related to the use of public procurement of innovation. The characteristics of pre-commercial procurement (PCP), as well as orders in the field of innovation (PPI) bring these institutions closer to each other. Innovative orders are changes in an approach to public procurement of regarding a purchase of goods, services and works from the perspective of purchasing products, or services which are incorporated the latest technical solutions or the latest technologies. It is also a change in the perception of public procurement as a tool to achieve goals, and meet defined needs by public entities.Autorka podejmuje problematykę zagadnienia zamówień publicznych na innowacje (PPI i PCP), przybliżając znaczenie tej instytucji prawnej, przedstawia i wyjaśnia ją przez wskazanie charakterystyki, zwracając uwagę na rolę, jaką spełniają w obrocie gospodarczym, oraz oczekiwania Unii Europejskiej związane z ich stosowaniem. Charakterystyka zamówień przedkomercyjnych (PCP), jak również zamówień w dziedzinie innowacji (PPI) przybliża każdą z nich, wskazując na funkcje i znaczenie. Zamówienia na innowacje to zmiany w podejściu zamówień publicznych do nabywanych towarów, usług i robót budowlanych z perspektywy nabywania produktów, usług zawierających w sobie najnowsze rozwiązania techniki czy też najnowsze technologie. To również zmiana postrzegania zamówień publicznych jako narzędzia do osiągania celów oraz zaspokajania zdefiniowanych potrzeb przez jednostki publiczne. Wyższa jakość realizowanych zadań ma stać się stymulatorem rozwoju gospodarki

INTRA-ORGANIZATIONAL TRUST AS A FACTOR THAT AFFECTS SATISFACTION WITH DOCTORAL STUDIES

The aim of the article is to examine intra-organizational trust as a factor impacting satisfaction with doctoral studies. The study on intra-organizational trust is related to three types of trust: vertical trust, horizontal trust and institutional trust. In turn, perceived satisfaction is linked to knowledge and competences gained at a university (academic satisfaction) and studying atmosphere (satisfaction with atmosphere). Furthermore, the following research questions were addressed in this paper: (1) Does personal experience from the past, current personal experience and the impact of surroundings affect particular types of trust? (2) Do particular types of trust and support provided by a university influence the willingness to take a risk? Therefore, in the underlying research the following factors that may be related to trust have been studied: university's support, willingness to take a risk, personal experience from the past, impact of surroundings. The sample consisted of 41 PhD students (26 women and 16 men). The Jagiellonian University has been represented by 11 doctorate student, where as  AGH University of Science and Technology surveyed 30 PhD students. The results of the study allow to answer the research question by pointing out to particular types of intra-organizational trust at a university as factors that affect PhD students’ satisfaction with doctoral studies. Study presents a positive correlation between intra-organizational trust and satisfaction at a university. Moreover, the impact of institutional trust on academic satisfaction and the influence of trust in lecturer and the impact of horizontal trust on satisfaction from atmosphere has been prove.