JNCC Offshore Natura Survey : Anton Dohrn Seamount and East Rockall Bank areas of search : 2009/03-JNCC Cruise Report

This cruise report summarises operations and initial observations onboard the M/V Franklin during cruise 2009/03-JNCC on behalf of the Joint Nature Conservation Committee (JNCC). The cruise took place between the 1st and 29th of July 2009 and surveyed two Areas of Search (AoS) for offshore Special Areas of Conservation (SACs): Anton Dohrn Seamount located 155km west of the St Kilda archipelago, and East Rockall Bank located 260km west of the St Kilda archipelago (Figure 1). The main aims of the survey were to acquire acoustic and photographic “ground-truthing” data to enable geological, geomorphological and biological characterisation of the Anton Dohrn Seamount and East Rockall Bank AoS. Specifically, the data acquired will lead to the production of broadscale habitat maps, the identification and description of Annex I reef habitats with particular attention to the occurrence of bedrock, stony and biogenic reef, to identify and record any anthropogenic impacts in the areas of search and finally to evaluate data acquisition methods, techniques and equipment. The work programme was highly successful with 215 line kilometres of multibeam echosounder and 10 photographic “ground-truthing” sites acquired in the Anton Dohrn Seamount AoS, and 692 line kilometres of multibeam echosounder and 168 line kilometres of sidescan sonar data and 17 photographic “ground-truthing” sites acquired in the East Rockall Bank AoS. No physical sea-bed samples were acquired during this cruise. The data revealed the flanks and area immediately adjacent to Anton Dohrn Seamount to comprise predominantly gravel-rich sediment with bedrock outcropping on the steeper sections of the Seamount flanks. East Rockall Bank comprised predominantly gravelly muddy sand on the eastern flank of the Bank with gravel- and sand-rich sediments dominating the crest of the Bank. Interestingly, the parasitic cones surveyed within the Anton Dohrn area of search comprised predominantly corals, including large gorgonian species, small bamboo coral, the soft coral Anthomastus sp. and the antipatharian Leiopathes sp. Significant bedrock reef was encountered during the course of this cruise along an escarpment located on the eastern flank of Rockall Bank roughly coincident with the 500m bathymetric contour. This laterally extensive feature primarily comprises volcanic bedrock with possible sedimentary bedrock cropping out at sea bed colonised by large stylsaterid hydrocorals and sponges. Preliminary observations and interpretation of the data acquired during the course of this cruise suggest that several sites may fit the definition of Annex I reef under the EC Habitats Directive. If they fulfil the criteria for Annex I reef, they will be assessed against site selection criteria as possible areas for consideration as SACs

Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration

Article approval pendingWith expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic failure and switching in children in South Africa

Visual pigments in a living fossil, the Australian lungfish Neoceratodus forsteri

Background. One of the greatest challenges facing the early land vertebrates was the need to effectively interpret a terrestrial environment. Interpretation was based on ocular adaptations evolved for an aquatic environment millions of years earlier. The Australian lungfish Neoceratodus forsteri is thought to be the closest living relative to the first terrestrial vertebrate, and yet nothing is known about the visual pigments present in lungfish or the early tetrapods. Results. Here we identify and characterise five visual pigments (rh1, rh2, lws, sws1 and sws2) expressed in the retina of N. forsteri. Phylogenetic analysis of the molecular evolution of lungfish and other vertebrate visual pigment genes indicates a closer relationship between lungfish and amphibian pigments than to pigments in teleost fishes. However, the relationship between lungfish, the coelacanth and tetrapods could not be absolutely determined from opsin phylogeny, supporting an unresolved trichotomy between the three groups. Conclusion. The presence of four cone pigments in Australian lungfish suggests that the earliest tetrapods would have had a colorful view of their terrestrial environment

Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaboration.

OBJECTIVES: To introduce the combined South African cohorts of the International epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) collaboration as reflecting the South African national antiretroviral treatment (ART) programme; to characterise patients accessing these services; and to describe changes in services and patients from 2003 to 2007. DESIGN AND SETTING: Multi-cohort study of 11 ART programmes in Gauteng, Western Cape, Free State and KwaZulu-Natal. SUBJECTS: Adults and children (<16 years old) who initiated ART with > or =3 antiretroviral drugs before 2008. RESULTS: Most sites were offering free treatment to adults and children in the public sector, ranging from 264 to 17,835 patients per site. Among 45,383 adults and 6,198 children combined, median age (interquartile range) was 35.0 years (29.8-41.4) and 42.5 months (14.7-82.5), respectively. Of adults, 68% were female. The median CD4 cell count was 102 cells/microl (44-164) and was lower among males than females (86, 34-150 v. 110, 50-169, p<0.001). Median CD4% among children was 12% (7-17.7). Between 2003 and 2007, enrolment increased 11-fold in adults and 3-fold in children. Median CD4 count at enrolment increased for all adults (67-111 cells/microl, p<0.001) and for those in stage IV (39-89 cells/microl, p<0.001). Among children <5 years, baseline CD4% increased over time (11.5-16.0%, p<0.001). CONCLUSIONS: IeDEA-SA provides a unique opportunity to report on the national ART programme. The study describes dramatically increased enrolment over time. Late diagnosis and ART initiation, especially of men and children, need attention. Investment in sentinel sites will ensure good individual-level data while freeing most sites to continue with simplified reporting

FACTORS INFLUENCING ‘BURN-OUT’ IN NEWLY-QUALIFIED COUNSELLORS AND PSYCHOTHERAPISTS: A CROSS-CULTURAL, CRITICAL REVIEW OF THE LITERATURE.

Mental health problems have been established as one of the leading causes of the global burden of disease. Approximately a quarter of all people worldwide will experience a mental disorder during their lifetime. With depression and anxiety becoming the leading causes of mental ill health globally, the numbers of people reporting mental health complaints are set to grow. The dramatic increase in reporting and diagnosis of mental health disorders has been in parallel to a decline in the ability to cope with mental health symptoms and a rise in the incidence of self-harm and suicidal ideation. Whilst mental health assessment and diagnoses are usually the responsibility of general practitioners (family doctors) or psychiatrists, the frontline provision of mental health care is often delegated to counsellors and psychotherapists. Publicly funded counselling and psychotherapy services vary across the globe, but are commonly under-resourced and lacking in adequate funding. This may lead to insufficient clinical supervision and compressed time to complete continuing professional development, which are both vital for new counsellors and psychotherapists to feel confident in providing care, and to learn new skills. Newly-qualified counsellors and psychotherapists may also experience emotional, physical, and mental exhaustion or ‘burn-out’. This position paper aims to critically appraise available cross-cultural literature on the experiences of ‘burn-out’ by newly-qualified counsellors and psychotherapists, globally. Finally, we shall make recommendations for how best to support the mental health and psychological wellbeing of newly-qualified practitioners

Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity, and perturb Ca2+ homeostasis in human coronary artery endothelial cells

The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a critical role in Ca2+ homeostasis via sequestration of this ion into the sarco/endoplasmic reticulum. The activity of this pump is inhibited by oxidants and impaired in ageing tissues and cardiovascular disease. We have shown previously that the myeloperoxidase- (MPO) derived oxidants HOCl and HOSCN target thiols and mediate cellular dysfunction. As SERCA contains Cys residues critical to ATPase activity, we hypothesized that HOCl and HOSCN might inhibit SERCA activity, via thiol oxidation, and increase cytosolic Ca2+ levels in human coronary artery endothelial cells (HCAEC). Exposure of sarcoplasmic reticulum vesicles to pre-formed or enzymatically-generated HOCl and HOSCN resulted in a concentration-dependent decrease in ATPase activity; this was also inhibited by the SERCA inhibitor thapsigargin. Decomposed HOSCN and incomplete MPO enzyme systems did not decrease activity. Loss of ATPase activity occurred concurrently with oxidation of SERCA Cys residues and protein modification. Exposure of HCAEC, with or without external Ca2+, to HOSCN or HOCl, resulted in a time- and concentration-dependent increase in intracellular Ca2+ under conditions that did not result in immediate loss of cell viability. Thapsigargin, but not inhibitors of plasma membrane or mitochondrial Ca2+ pumps/channels, completely attenuated the increase in intracellular Ca2+ consistent with a critical role for SERCA in maintaining endothelial cell Ca2+ homeostasis. Angiotensin II pre-treatment potentiated the effect of HOSCN at low concentrations. MPO-mediated modulation of intracellular Ca2+ levels may exacerbate endothelial dysfunction, a key early event in atherosclerosis, and be more marked in smokers due to their higher SCN− levels

Are You Sure? Confidence about the Satiating Capacity of a Food Affects Subsequent Food Intake

Expectations about a food’s satiating capacity predict self-selected portion size, food intake and food choice. However, two individuals might have a similar expectation, but one might be extremely confident while the other might be guessing. It is unclear whether confidence about an expectation affects adjustments in energy intake at a subsequent meal. In a randomized cross-over design, 24 subjects participated in three separate breakfast sessions, and were served a low-energy-dense preload (53 kcal/100 g), a high-energy-dense preload (94 kcal/100 g), or no preload. Subjects received ambiguous information about the preload’s satiating capacity and rated how confident they were about their expected satiation before consuming the preload in its entirety. They were served an ad libitum test meal 30 min later. Confidence ratings were negatively associated with energy compensation after consuming the high-energy-dense preload (r = −0.61; p = 0.001). The same relationship was evident after consuming the low-energy-dense preload, but only after controlling for dietary restraint, hunger prior to, and liking of the test meal (p = 0.03). Our results suggest that confidence modifies short-term controls of food intake by affecting energy compensation. These results merit consideration because imprecise caloric compensation has been identified as a potential risk factor for a positive energy balance and weight gain

8000 years of North Atlantic storminess reconstructed from a Scottish peat record: implications for Holocene atmospheric circulation patterns in Western Europe

North Atlantic storminess can affect human settlements, infrastructure and transport links, all of which strongly impact local, national and global economies. An increase in storm frequency and intensity is predicted over the Northeast Atlantic in the 21st century because of a northward shift in storm tracks and a persistently positive North Atlantic Oscillation (NAO), driven by recent atmospheric warming. Although documentary records of North Atlantic storminess exist, these are generally limited to the last c. 1000‐2000 years. This paper presents a continuous high‐resolution proxy record of storminess spanning the last 8000 years from a 6 m long core taken from a peat bog in Northern Scotland. Bromine concentrations in the peat, derived from sea spray, are used to reconstruct storm frequency and storm intensity, and mire surface wetness is used as an indicator of longer‐term climate shifts. The results suggest a relationship between positive phases of the NAO and increased North Atlantic storminess. However, subtle differences between bromine concentrations and mire surface wetness suggest that high intensity but perhaps less frequent periods of storminess are not necessarily associated with a wetter climate

Comparison of Parent Questionnaires, Examiner-Led Assessment and Parents' Concerns at 14 Months of Age as Indicators of Later Diagnosis of Autism.

Parents participating in a prospective longitudinal study of infants with older siblings with autism completed an autism screening questionnaire and were asked about any concerns relating to their child's development, and children were administered an interactive assessment conducted by a researcher at 14 months. Scores on the parent questionnaire were highest for children later diagnosed with autism. Parental concerns and scores from the examiner-led assessment distinguished children with later developmental difficulties (both autism and other developmental atypicalities) from those who were developing typically. Children about whom parents expressed concern scored higher on both the questionnaire and the interactive assessment than those without concerns. There were no significant associations between total or individual item scores from the questionnaire and interactive assessment