199 research outputs found
The equivalence theorem and the Bethe-Salpeter equation
We solve the Bethe-Salpeter equation for two-particle scattering in a
field-theoretical model using two lagrangians related by a field
transformation. The kernel of the equation consists of the sum of all
tree-level diagrams for each lagrangian. The solutions differ even if all four
external particles are put on the mass shell, which implies that observables
calculated by solving the Bethe-Salpeter equation depend on the representation
of the theory. We point out that this violation of the equivalence theorem has
a simple explanation and should be expected for any Bethe-Salpeter equation
with a tree-level kernel. Implications for dynamical models of hadronic
interactions are discussed.Comment: 10 pages, 4 figures, using REVTeX. Fig. 2 corrected, results
unchanged, to be published in Phys. Lett.
Reaction and Axial Vector Coupling
The reaction is studied in the region of low
to investigate the effect of deuteron structure and width of the
resonance on the differential cross section. The results are used to extract
the axial vector coupling from the experimental data on
this reaction. The possibility to determine this coupling from electroweak
interaction experiments with high intensity electron accelerators is discussed.Comment: 14 pages, REVTEX, 5 figure
Proton-proton bremsstrahlung below and above pion-threshold: the influence of the -isobar
The proton-proton bremsstrahlung is investigated within a coupled-channel
model with the degree of freedom. The model is consistent with the
scattering up to 1 GeV and the vertex determined in the
study of pion photoproduction reactions. It is found that the
excitation can significantly improve the agreements with the at MeV. Predictions at and MeV are
presented for future experimental tests.Comment: 26 pages Revtex, 12 figures are available from the authors upon
request ([email protected]
Dressing the nucleon in a dispersion approach
We present a model for dressing the nucleon propagator and vertices. In the
model the use of a K-matrix approach (unitarity) and dispersion relations
(analyticity) are combined. The principal application of the model lies in
pion-nucleon scattering where we discuss effects of the dressing on the phase
shifts.Comment: 17 pages, using REVTeX, 6 figure
Astrophysical Reaction Rates for B(p,)Be and B(p,)Be From a Direct Model
The reactions B(p,)Be and B(p,)Be
are studied at thermonuclear energies using DWBA calculations. For both
reactions, transitions to the ground states and first excited states are
investigated. In the case of B(p,)Be, a resonance at
keV can be consistently described in the potential model, thereby
allowing the extension of the astrophysical -factor data to very low
energies. Strong interference with a resonance at about keV
require a Breit-Wigner description of that resonance and the introduction of an
interference term for the reaction B(p,)Be. Two
isospin resonances (at keV and keV)
observed in the B+p reactions necessitate Breit-Wigner resonance and
interference terms to fit the data of the B(p,)Be
reaction. -factors and thermonuclear reaction rates are given for each
reaction. The present calculation is the first consistent parametrization for
the transition to the ground states and first excited states at low energies.Comment: 27 pages, 5 Postscript figures, uses RevTex and aps.sty; preprint
also available at http://quasar.physik.unibas.ch/ Phys. Rev. C, in pres
Pion photoproduction on the nucleon in the quark model
We present a detailed quark-model study of pion photoproduction within the
effective Lagrangian approach. Cross sections and single-polarization
observables are investigated for the four charge channels, , , , and .
Leaving the coupling strength to be a free parameter, we obtain a
reasonably consistent description of these four channels from threshold to the
first resonance region. Within this effective Lagrangian approach, strongly
constrainted by the quark model, we consider the issue of double-counting which
may occur if additional {\it t}-channel contributions are included.Comment: Revtex, 35 pages, 16 eps figures; version to appear on PR
Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop
Aims/hypothesis:
Validated biomarkers are needed to monitor the effects of immune intervention in individuals with type 1 diabetes. Despite their importance, few options exist for monitoring antigen-specific T cells. Previous reports described a combinatorial approach that enables the simultaneous detection and quantification of multiple islet-specific CD8+ T cell populations. Here, we set out to evaluate the performance of a combinatorial HLA-A2 multimer assay in a multi-centre setting.
Methods:
The combinatorial HLA-A2 multimer assay was applied in five participating centres using centralised reagents and blinded replicate samples. In preliminary experiments, samples from healthy donors were analysed using recall antigen multimers. In subsequent experiments, samples from healthy donors and individuals with type 1 diabetes were analysed using beta cell antigen and recall antigen multimers.
Results:
The combinatorial assay was successfully implemented in each participating centre, with CVs between replicate samples that indicated good reproducibility for viral epitopes (mean %CV = 33.8). For beta cell epitopes, the assay was very effective in a single-centre setting (mean %CV = 18.4), but showed sixfold greater variability across multi-centre replicates (mean %CV = 119). In general, beta cell antigen-specific CD8+ T cells were detected more commonly in individuals with type 1 diabetes than in healthy donors. Furthermore, CD8+ T cells recognising HLA-A2-restricted insulin and glutamate decarboxylase epitopes were found to occur at higher frequencies in individuals with type 1 diabetes than in healthy donors.
Conclusions/interpretation
Our results suggest that, although combinatorial multimer assays are challenging, they can be implemented in multiple laboratories, providing relevant T cell frequency measurements. Assay reproducibility was notably higher in the single-centre setting, suggesting that biomarker analysis of clinical trial samples would be most successful when assays are performed in a single laboratory. Technical improvements, including further standardisation of cytometry platforms, will likely be necessary to reduce assay variability in the multi-centre setting
Future Directions in Parity Violation: From Quarks to the Cosmos
I discuss the prospects for future studies of parity-violating (PV)
interactions at low energies and the insights they might provide about open
questions in the Standard Model as well as physics that lies beyond it. I cover
four types of parity-violating observables: PV electron scattering; PV hadronic
interactions; PV correlations in weak decays; and searches for the permanent
electric dipole moments of quantum systems.Comment: Talk given at PAVI 06 workshop on parity-violating interactions,
Milos, Greece (May, 2006); 10 page
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