State total microcirculation in patients with hemophilia

The paper presents the results of the study total microcirculation in patients with hemophilia, obtained using laser Doppler flowmetry. Revealed asymmetric reduction of perfusion, increase the maximum amplitude of violations of microcirculation

Screening for gastroesophageal reflux disease

The Purpose of research. To estimate a role of screening in revealing sick gastroesophageal reflux disease (GERD) and training of these patients in «To School of patients GERD» at an dispensary-polyclinic stage by means of studying an estimation of quality of a life. Materials and methods. Tests for presence gastroesophageal reflux disease developed by professor V.A. Isakovym (MRSRI n. M.F.Vladimirsky) and an estimation of quality of a life (questionnaire SF-36 created J.E. Ware) have passed 180 patients who have addressed the dispensary-polyclinic help. By results of testing interrogated have been divided into 2 groups: 1-st with presence gastroesophageal reflux disease, 2-nd — without symptoms gastroesophageal a reflux. An estimation of quality of a life spent a method of summation of estimations Likerti on the basis of code conversion of intermediate values by means of the software distributed by company QMetric Inc (MOS SF-36. The Health Institute, New England Medical Center, Boston, USA). Retrospectivity electronic out-patient cards of all patients are studied, results esophagogastroduodenoscopy and contrast rentghenoskopy the top departments of a digestive path are analysed. Results. More than half of the patients who have addressed the dispensary-polyclinic help, had symptoms gastroesophageal reflux disease. Gastroesophageal reflux disease proceeded under «Masks» other diseases, and their mutual influence led to a syndrome of mutual burdening. The conclusion. Screening of patients at an dispensary stage allows to reveal symptoms gastroesophageal a reflux, to define further tactics of inspection and treatment, and training of patients will allow to reduce clinical displays of this pathology and to warn complications.Цель исследования. Оценить роль скрининга в выявлении больных гастроэзофагеальной рефлюксной болезнью (ГЭРБ) и обучения этих пациентов в «Школе больных ГЭРБ» на амбулаторно-поликлиническом этапе с помощью изучения оценки качества жизни. Материалы и методы. Тесты на наличие гастроэзофагеальной рефлюксной болезни, разработанные профессором В.А. Исаковым (МОНИКИ им. М.Ф. Владимирского) и оценку качества жизни (опросник SF-36, созданный J.E. Ware) прошли 180 пациентов, обратившихся за амбулаторно-поликлинической помощью. По результатам тестирования опрошенные были разделены на 2 группы: 1-я с наличием гастроэзофагеальной рефлюксной болезни, 2-я — без симптомов гастро-эзофагеального рефлюкса. Оценку качества жизни проводили методом суммирования оценок Ликерта на основе перекодировки промежуточных значений с помощью программного обеспечения, распространяемого компанией QMetric Inc (MOS SF-36. The Health Institute, New England Medical Center, Boston, USA). Ретроспективно изучены электронные амбулаторные карты всех больных, проанализированы результаты ФГДС и контрастной рентгеноскопии верхних отделов пищеварительного тракта. Результаты. Более половины пациентов, обратившихся за амбулаторно-поликлинической помощью, имели симптомы гастроэзофагеальной рефлюксной болезни. Гастроэзофагеальная рефлюксная болезнь протекала под «масками» других заболеваний, а их взаимное влияние приводило к синдрому взаимного отягощения. Заключение. Скрининг пациентов на амбулаторном этапе позволяет выявить симптомы гастроэзофагеального рефлюкса, определить дальнейшую тактику обследования и лечения, а обучение больных позволит уменьшить клинические проявления этой патологии и предупредить осложнения

Evaluation of anemia syndrom in haemophilia

In work risk factors of development of an anemia at patients with a hemophilia are analyzed. The anemia met more often at the heavy form of disease, at persons with A (II) group of blood (40%)

Travellers returning with measles from Thailand to Finland, April 2012: infection control measures

Peer reviewe

The experience of a minimally invasive retroperitoneoscopic operation on ureter in case of megaureteritis

The study shows the data of reconstructive surgery in case of megaureteritis using a minimally invasive open retroperitoneoscopic operation (RPNS). 16 reconstructive operations have been made in the urology clinic of The Ural State Medical Academy of Roszdrav since 2005. The combined intermuscle-splitting approach for urethroplication and urethrovesicoanastomosis was used for the first time. It makes a proper condition in a wound for operation on ureter, vesicoureteral segment. That allows to reach the main aim — the elimination of vesicoureteral fistula obstruction along with minimally traumatic operation, and terms of medical treatment of a patient in the hospital due to operative trauma and number of medicine abatement, good cosmetic effect.В работе представлены данные о выполнении реконструктивных операций при мегауретере с использованием малоинвазивной открытой ретроперитонеоскопии (РПС). С 2005 г. в клинике урологии УГМА выполнено 16 таких реконструктивных операций. При этом впервые применен комбинированный межмышечный доступ для проведения уретеропликации и уретеровезикоанастомоза, что создает достаточные условия в ране для вмешательства на мочеточнике, пузырно-мочеточниковом сегменте, позволяющие достигнуть основной цели — ликвидации обструкции пузырно-мочеточникового соустья при минимальной травматичности операции, снижения продолжительности пребывания больного в стационаре за счет уменьшения операционной травмы, уменьшения количества лекарственных препаратов, а также хорошего косметического эффекта

Standardization of measles, mumps and rubella assays to enable comparisons of seroprevalence data across 21 European countries and Australia

The aim of the European Sero-Epidemiology Network is to establish comparability of the serological surveillance of vaccine-preventable diseases in Europe. The designated reference laboratory (RL) for measles, mumps, rubella (MMR) prepared and tested a panel of 151 sera by the reference enzyme immunoassay (rEIA). Laboratories in 21 countries tested the panel for antibodies against MMR using their usual assay (a total of 16 different EIAs) and the results were plotted against the reference results in order to obtain equations for the standardization of national serum surveys. The RL also tested the panel by the plaque neutralization test (PNT). Large differences in qualitative results were found compared to the RL. Well-fitting standardization equations with R20·8 were obtained for almost all laboratories through regression of the quantitative results against those of the RL. When compared to PNT, the rEIA had a sensitivity of 95·3%, 92·8% and 100% and a specificity of 100%, 87·1% and 92·8% for measles, mumps and rubella, respectively. The need for standardization was highlighted by substantial inter-country differences. Standardization was successful and the selected standardization equations allowed the conversion of local serological results into common units and enabled direct comparison of seroprevalence data of the participating countrie

Reliability of medical students' vaccination histories for immunisable diseases

<p>Abstract</p> <p>Background</p> <p>Medical students come into contact with infectious diseases early on their career. Immunity against vaccine-preventable diseases is therefore vital for both medical students and the patients with whom they come into contact.</p> <p>Methods</p> <p>The purpose of this study was to compare the medical history and serological status of selected vaccine-preventable diseases of medical students in Germany.</p> <p>Results</p> <p>The overall correlation between self-reported medical history statements and serological findings among the 150 students studied was 86.7 %, 66.7 %, 78 % and 93.3 % for measles, mumps, rubella and varicella, conditional on sufficient immunity being achieved after one vaccination. Although 81.2 % of the students' medical history data correlated with serological findings, significant gaps in immunity were found.</p> <p>Conclusion</p> <p>Our findings indicate that medical history alone is not a reliable screening tool for immunity against the vaccine-preventable diseases studied.</p

Residual susceptibility to measles among young adults in Victoria, Australia following a national targeted measles-mumps-rubella vaccination campaign

<p>Abstract</p> <p>Background</p> <p>Past measles immunisation policies in Australia have resulted in a cohort of young adults who have been inadequately vaccinated, but who also have low levels of naturally acquired immunity because immunisation programs have decreased the circulation of wild virus. A measles-mumps-rubella (MMR) immunisation campaign aimed at addressing this susceptibility to measles among young adults was conducted in Australia in 2001–2. By estimating age-specific immunity, we aimed to evaluate the success of this campaign in the state of Victoria.</p> <p>Methods</p> <p>We conducted serosurveys after the young adult MMR program at state and national levels to estimate immunity among young adults born between 1968–82. We compared results of the Victorian (state) surveys with the Victorian component of the national surveys and compared both surveys with surveys conducted before the campaign. We also reviewed all laboratory confirmed measles cases in Victoria between 2000–4.</p> <p>Results</p> <p>The Victorian state serosurveys indicated no significant change in immunity of the cohort following the young adult MMR campaign (83.9% immune pre and 85.5% immune post campaign) while the Victorian component of the national serosurvey indicated a significant decline in immunity (91.0% to 84.2%; p = 0.006). Both surveys indicated about 15% susceptibility to measles among young Victorian adults after the campaign. Measles outbreaks in Victoria between 2000–4 confirmed the susceptibility of young adults. Outbreaks involved a median of 2.5 cases with a median age of 24.5 years.</p> <p>Conclusion</p> <p>In Victoria, the young adult MMR program appears to have had no effect on residual susceptibility to measles among the 1968–82 birth cohort. Young adults in Victoria, as in other countries where past immunisation policies have left a residual susceptible cohort, represent a potential problem for the maintenance of measles elimination.</p