Probing the helium-graphite interaction

Two separate lines of investigation have recently converged to produce a highly detailed picture of the behavior of helium atoms physisorbed on graphite basal plane surfaces. Atomic beam scattering experiments on single crystals have yielded accurate values for the binding energies of several· states for both (^4)He and (^3)He, as well as matrix elements of the largest Fourier component of the periodic part of the interaction potential. From these data, a complete three-dimensional description of the potential has been constructed, and the energy band structure of a helium atom moving in this potential calculated. At the same time, accurate thermodynamic measurements were made on submonolayer helium films adsorbed on Grafoil. The binding energy and low-coverage specific heat deduced from these measurements are in excellent agreement with those calculated from the band structures

A kiloparsec-scale nuclear stellar disk in the milky way as a possible explanation of the high velocity peaks in the galactic bulge

The Apache Point Observatory Galactic Evolution Experiment has measured the stellar velocities of red giant stars in the inner Milky Way. We confirm that the line of sight velocity distributions (LOSVDs) in the mid-plane exhibit a second peak at high velocities, whereas those at | b| =2^\circ do not. We use a high resolution simulation of a barred galaxy, which crucially includes gas and star formation, to guide our interpretation of the LOSVDs. We show that the data are fully consistent with the presence of a thin, rapidly rotating, nuclear disk extending to ∼1 kpc. This nuclear disk is orientated perpendicular to the bar and is likely to be composed of stars on x2 orbits. The gas in the simulation is able to fall onto such orbits, leading to stars populating an orthogonal disk

Osteology of the American Plaice, Hippoglossoides platessoides

The Hippoglossoides platessoides skeleton is described and figured; for these purposes 17 specimens were observed. Study material was prepared by fleshing and disarticulation or by clearing and staining. Skull lengths of the specimens examined ranged from 27 to 68 mm and total lengths from 181 to 851 mm. Paired lacrymals constitute the only suborbital elements, although canal ossicles occur on both sides. A single nasal houses a portion of the supraorbital lateral-line canal of the right eye. Right elements of the oromandibular region are anterior and ventral to their left counterparts. Three left jaw bones, premaxillary, maxillary and dentary, are longer than the right elements. Tooth-bearing structures are represented by the premaxillaries, dentaries, pharyngobranchials (2-4) and ceratobranchials (5). The spine of the neural process of the first trunk vertebra extends well above the cranium whereas its arch in part lies sessile on the second centrum. Additional pleural and epipleural ribs may be found on the right side. Lateral apophyses are confined to the right side but arise from trunk and caudal centra. The specialized caudal skeleton consists of 18 branched lepidotrichs, 1 parhypural, 2 hypural plates and 2 epurals

Seismic hazard due to fluid injections

Earthquakes can be induced by natural and anthropogenic processes involving the injection or migration of fluids within rock formations. A variety of field observations has led to the formulation of three different and apparently contradicting paradigms in the estimation of the seismic hazard associated with fluid injections. We introduce a unified conceptual model accounting for the nonhomogeneous pore-pressure stimulation caused by fluid injection in a prestressed region, to prove how all three paradigms can naturally coexist. Within our model framework the loading history, accounting for both the fluid injections and natural tectonic loading, together with the heterogeneity of the host medium determine which of the three paradigms prevails at a given time. We identify a superposition of two populations of events triggered at different local stress levels with different Gutenberg-Richter b-values. Our findings suggest that both the observed diversity of b-values across different fluid-induced settings and the dominating hazard paradigm are a consequence of such a superposition leading to an effective b-value

Energy and Charged Particle Flow in 10.8 A GeV/c Au+Au Collisions

Experimental results and a detailed analysis are presented of the transverse energy and charged particle azimuthal distributions measured by the E877 collaboration for different centralities of Au+Au collisions at a beam momentum of 10.8 A GeV/c. The anisotropy of these distributions is studied with respect to the reaction plane reconstructed on an event-by-event basis using the transverse energy distribution measured by calorimeters. Results are corrected for the reaction plane resolution. For semicentral events we observe directed flow signals of up to ten percent. We observe a stronger anisotropy for slow charged particles. For both the charged particle and transverse energy distributions we observe a small but non zero elliptic anisotropy with the major axis pointing into the reaction plane. Combining the information on transverse energy and charged particle flow we obtain information on the flow of nucleons and pions. The data are compared to event generators and the need to introduce a mean field or nucleon-nucleon potential is discussed.Comment: RevTex, 25 pages, 13 figures included as one Postscript file, submitted to Phys. Rev.

Reliable in silico ranking of engineered therapeutic TCR binding affinities with MMPB/GBSA

Accurate and efficient in silico ranking of proteinprotein binding affinities is useful for protein design with applications in biological therapeutics. One popular approach to rank binding affinities is to apply the molecular mechanics Poisson-Boltzmann/generalized Born surface area (MMPB/ GBSA) method to molecular dynamics (MD) trajectories. Here, we identify protocols that enable the reliable evaluation of T-cell receptor (TCR) variants binding to their target, peptide-human leukocyte antigens (pHLAs). We suggest different protocols for variant sets with a few (<= 4) or many mutations, with entropy corrections important for the latter. We demonstrate how potential outliers could be identified in advance and that just 5-10 replicas of short (4 ns) MD simulations may be sufficient for the reproducible and accurate ranking of TCR variants. The protocols developed here can be applied toward in silico screening during the optimization of therapeutic TCRs, potentially reducing both the cost and time taken for biologic development

The formation of stellar nuclear discs in bar-induced gas inflows

The role of gas in the mass assembly at the nuclei of galaxies is still subject to some uncertainty. Stellar nuclear discs bridge the gap between the large-scale galaxy and the central massive objects that reside there. Using a high-resolution simulation of a galaxy forming out of gas cooling and settling into a disc, we study the formation and properties of nuclear discs. Gas, driven to the centre by a bar, settles into a rotating star-forming nuclear disc (ND). This ND is thinner, younger, kinematically cooler and more metal rich than the surrounding bar. The ND is elliptical and orthogonal to the bar. The complex kinematics in the region of the ND are a result of the superposition of older stars streaming along the bar and younger stars circulating within the ND. The signature of the ND is therefore subtle in the kinematics. Instead the ND stands out clearly in metallicity and age maps. We compare the model to the density and kinematics of real galaxies with NDs finding qualitative similarities. Our results suggest that gas dissipation is very important for forming nuclear structure