The flat phase of fixed-connectivity membranes

The statistical mechanics of flexible two-dimensional surfaces (membranes) appears in a wide variety of physical settings. In this talk we discuss the simplest case of fixed-connectivity surfaces. We first review the current theoretical understanding of the remarkable flat phase of such membranes. We then summarize the results of a recent large scale Monte Carlo simulation of the simplest conceivable discrete realization of this system \cite{BCFTA}. We verify the existence of long-range order, determine the associated critical exponents of the flat phase and compare the results to the predictions of various theoretical models.Comment: 7 pages, 5 figures, 3 tables. LaTeX w/epscrc2.sty, combined contribution of M. Falcioni and M. Bowick to LATTICE96(gravity), to appear in Nucl. Phys. B (proc. suppl.

CRF1 Receptor Activation Increases the Response of Neurons in the Basolateral Nucleus of the Amygdala to Afferent Stimulation

The basolateral nucleus (BLA) of the amygdala contributes to the consolidation of memories for emotional or stressful events. The nucleus contains a high density of CRF1 receptors that are activated by corticotropin-releasing factor (CRF). Modulation of the excitability of neurons in the BLA by CRF may regulate the immediate response to stressful events and the formation of associated memories. In the present study, CRF was found to increase the amplitude of field potentials recorded in the BLA following excitatory afferent stimulation, in vitro. The increase was mediated by CRF1 receptors, since it could be blocked by the selective, non-peptide antagonists, NBI30775 and NBI35583, but not by the CRF2-selective antagonist, astressin 2B. Furthermore, the CRF2-selective agonist, urocortin II had no effect on field potential amplitude. The increase induced by CRF was long-lasting, could not be reversed by subsequent administration of NBI35583, and required the activation of protein kinase C. This effect of CRF in the BLA may be important for increasing the salience of aversive stimuli under stressful conditions, and for enhancing the consolidation of associated memories. The results provide further justification for studying the efficacy of selective antagonists of the CRF1 receptor to reduce memory formation linked to emotional or traumatic events, and suggest that these compounds might be useful as prophylactic treatments for stress-related illnesses such as post-traumatic stress disorder

M.C.R.G. Study of Fixed-connectivity Surfaces

We apply Monte Carlo Renormalization group to the crumpling transition in random surface models of fixed connectivity. This transition is notoriously difficult to treat numerically. We employ here a Fourier accelerated Langevin algorithm in conjunction with a novel blocking procedure in momentum space which has proven extremely successful in $\lambda\phi^4$. We perform two successive renormalizations in lattices with up to $64^2$ sites. We obtain a result for the critical exponent $\nu$ in general agreement with previous estimates and similar error bars, but with much less computational effort. We also measure with great accuracy $\eta$. As a by-product we are able to determine the fractal dimension $d_H$ of random surfaces at the crumpling transition.Comment: 35 pages,Latex file, 6 Postscript figures uuencoded,uses psfig.sty 2 misspelled references corrected and one added. Paper unchange

Evaluation of a community‐based early childhood caries (ECC) intervention in Cambodia

Objective: To critically evaluate an early childhood caries (ECC) intervention performed by non-dental primary healthcare providers. Methods: This mixed-methods investigation includes data from three sources: (a) a pilot non-randomized controlled trial to examine clinical outcomes at four health centres; (b) stakeholder focus group interviews; and (c) a survey of parents whose children were exposed to the intervention. The pilot study involved four Community Health Centres in rural Cambodia whereby mother-child (6-24 months of age)dyads received oral health education (OHE), toothbrushes, fluoride toothpaste and fluoride varnish on up to six occasions as part of the routine vaccination schedule. Outcomes were as follows: presence of ECC; impacts on oral health-related quality of life (OHRQoL); stakeholder perceptions of intervention delivery; and parental perceptions of fluoride varnish. Results: Participants in the intervention group had six times lower odds of developing ECC than those in the comparison group after controlling for socio-economic status (OR 0.13). Those in the intervention group also had a large reduction OHRQoL scale scores. Key knowledge and practice gaps were identified among stakeholders. Surveyed parents had favourable views of the fluoride varnish placement by medical professionals, and four out of five stated that they would recommend fluoride varnish for other children. Primary healthcare providers, commune council representatives and community health promoters supported oral health interventions being provided in CHCs. Conclusions: OHE and fluoride varnish interventions provided by non-dental primary health workers were feasible and acceptable for stakeholders in a Cambodian setting. The intervention group had lower ECC experience and better OHRQoL at 2 years of age

Generalization of the Bollob\'as-Riordan polynomial for tensor graphs

Tensor models are used nowadays for implementing a fundamental theory of quantum gravity. We define here a polynomial $\mathcal T$ encoding the supplementary topological information. This polynomial is a natural generalization of the Bollob\'as-Riordan polynomial (used to characterize matrix graphs) and is different of the Gur\uau polynomial, (R. Gur\uau, "Topological Graph Polynomials in Colored Group Field Theory", Annales Henri Poincare {\bf 11}, 565-584 (2010)) defined for a particular class of tensor graphs, the colorable ones. The polynomial $\mathcal T$ is defined for both colorable and non-colorable graphs and it is proved to satisfy the contraction/deletion relation. A non-trivial example of a non-colorable graphs is analyzed.Comment: 22 pages, 20 figure

Comparative Pathway Analyzer—a web server for comparative analysis, clustering and visualization of metabolic networks in multiple organisms

In order to understand the phenotype of any living system, it is essential to not only investigate its genes, but also the specific metabolic pathway variant of the organism of interest, ideally in comparison with other organisms. The Comparative Pathway Analyzer, CPA, calculates and displays the differences in metabolic reaction content between two sets of organisms. Because results are highly dependent on the distribution of organisms into these two sets and the appropriate definition of these sets often is not easy, we provide hierarchical clustering methods for the identification of significant groupings. CPA also visualizes the reaction content of several organisms simultaneously allowing easy comparison. Reaction annotation data and maps for visualizing the results are taken from the KEGG database. Additionally, users can upload their own annotation data. This website is free and open to all users and there is no login requirement. It is available at https://www.cebitec.uni-bielefeld.de/groups/brf/software/cpa/index.html