655 research outputs found
Identification of vortexes obstructing the dynamo mechanism in laboratory experiments
The magnetohydrodynamic dynamo effect explains the generation of
self-sustained magnetic fields in electrically conducting flows, especially in
geo- and astrophysical environments. Yet the details of this mechanism are
still unknown, e.g., how and to which extent the geometry, the fluid topology,
the forcing mechanism and the turbulence can have a negative effect on this
process. We report on numerical simulations carried out in spherical geometry,
analyzing the predicted velocity flow with the so-called Singular Value
Decomposition, a powerful technique that allows us to precisely identify
vortexes in the flow which would be difficult to characterize with conventional
spectral methods. We then quantify the contribution of these vortexes to the
growth rate of the magnetic energy in the system. We identify an axisymmetric
vortex, whose rotational direction changes periodically in time, and whose
dynamics are decoupled from those of the large scale background flow, is
detrimental for the dynamo effect. A comparison with experiments is carried
out, showing that similar dynamics were observed in cylindrical geometry. These
previously unexpected eddies, which impede the dynamo effect, offer an
explanation for the experimental difficulties in attaining a dynamo in
spherical geometry.Comment: 25 pages, 12 figures, submitted to Physics of Fluid
Transport Barriers in Magnetized Plasmas -- General Theory with Dynamical Constraints
A fundamental dynamical constraint -- that fluctuation induced
charge-weighted particle flux must vanish -- can prevent instabilities from
accessing the free energy in the strong gradients characteristic of Transport
Barriers (TBs). Density gradients, when larger than a certain threshold, lead
to a violation of the constraint and emerge as a stabilizing force. This
mechanism, then, broadens the class of configurations (in magnetized plasmas)
where these high confinement states can be formed and sustained. The need for
velocity shear, the conventional agent for TB formation, is obviated. The most
important ramifications of the constraint is to permit a charting out of the
domains conducive to TB formation and hence to optimally confined fusion worthy
states; the detailed investigation is conducted through new analytic methods
and extensive gyrokinetic simulations
Deep high-resolution X-ray spectra from cool-core clusters
We examine deep XMM-Newton Reflection Grating Spectrometer (RGS) spectra from
the cores of three X-ray bright cool core galaxy clusters, Abell 262, Abell
3581 and HCG 62. Each of the RGS spectra show Fe XVII emission lines indicating
the presence of gas around 0.5 keV. There is no evidence for O VII emission
which would imply gas at still cooler temperatures. The range in detected gas
temperature in these objects is a factor of 3.7, 5.6 and 2 for Abell 262, Abell
3581 and HCG 62, respectively. The coolest detected gas only has a volume
filling fraction of 6 and 3 per cent for Abell 262 and Abell 3581, but is
likely to be volume filling in HCG 62. Chandra spatially resolved spectroscopy
confirms the low volume filling fractions of the cool gas in Abell 262 and
Abell 3581, indicating this cool gas exists as cold blobs. Any volume heating
mechanism aiming to prevent cooling would overheat the surroundings of the cool
gas by a factor of 4. If the gas is radiatively cooling below 0.5 keV, it is
cooling at a rate at least an order of magnitude below that at higher
temperatures in Abell 262 and Abell 3581 and two-orders of magnitude lower in
HCG 62. The gas may be cooling non-radiatively through mixing in these cool
blobs, where the energy released by cooling is emitted in the infrared. We find
very good agreement between smooth particle inference modelling of the cluster
and conventional spectral fitting. Comparing the temperature distribution from
this analysis with that expected in a cooling flow, there appears to be a even
larger break below 0.5 keV as compared with previous empirical descriptions of
the deviations of cooling flow models.Comment: 19 pages, 22 figures, accepted by MNRA
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Ecological baselines for Oregon's coast: a report for agencies that manage Oregon's coastal habitats for ecological and economic sustainability, and for all who are interested in the welfare of wildlife that inhabit our coast and its estuaries
Against the backdrop of growing concern about dead zones, rare and endangered sea mammals, depletion of Oregon’s once‐abundant fish stocks, acidification threatening coastal molluscs, and proposals for marine reserves along Oregon’s coastline, a multidisciplinary group of scientists was called together in 2008 to discuss what is known about Oregon’s coastal resources at specific points in the past. They agreed that knowing more about the condition of resources in the past could help state resource agencies understand its ecological potential and such information would be useful in planning restoration projects as well as determining gaps in knowledge that need to be filled. Called together by John Meyer, representing Communication Partnership for Science and the Sea (COMPASS), the group decided to develop an “Ecological Baselines” report on past coastal resources at whatever times empirical data exist. We begin this report with a chapter reviewing archaeological, ethnographic, and historic materials to provide a picture of Oregon’s coastal resources before 1750. Subsequent chapters consider salmon, sea otters, and sub‐tidal sea urchins. The salmon chapter provides details on twentieth century abundance and decline of one of Oregon’s most charismatic and economically important ocean resources. This chapter’s authors also evaluate remedies that have attempted to restore salmon species. Next, the sea otter chapter describes a mammal once abundant but no longer present on the Oregon coast, and discusses what the coast has lost by its demise. A decade ago, the author, a descendant of Aleut and Coos/Siuslaw natives, organized a multi‐disciplinary project, named The Elakha Alliance, to study and consider restoration of this keystone species. The sub‐tidal purple sea urchin, described in our fourth chapter, in contrast to salmon and otter, is so small that the intense labor required to harvest it has protected it from commercial harvesting. However, the urchin is affected by all the forces that impinge on the coast’s ecological web, and warming seas could affect its ability to survive along Oregon’s coast. Not all developments in the past decades have been negative. We discuss major estuary restoration projects on the Salmon River and the Coquille River that show how restoration is working in these areas and that suggest how other estuary restorations could proceed. On Tuesday Feb. 22, 2012, the Oregon legislature passed a bill that will add 38 square miles of marine reserves in Oregon’s territorial waters at five locations. And in our final section, the epilogue discusses a significant new paradigm for understanding the process of ecological collapse, beginning with the removal of top consumers – keystone predators. This multi‐authored review, published in Science in 2011, thereby suggests ecosystem wide strategies for restoration and stability (Estes et al., 2011). Our report on historical, ecological baselines is only a first step in a compilation of information on significant coastal resources that we believe could encourage additional research and longterm strategies for restoration
Associations between childhood maltreatment and inflammatory markers.
BACKGROUND:Childhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.AimsTo determine the effects of childhood maltreatment on circulating levels of 41 inflammatory markers in healthy individuals and those with a major depressive disorder (MDD) diagnosis. METHOD:We investigated the association of childhood maltreatment with levels of 41 inflammatory markers in two groups, 164 patients with MDD and 301 controls, using multiplex electrochemiluminescence methods applied to blood serum. RESULTS:Childhood maltreatment was not associated with altered inflammatory markers in either group after multiple testing correction. Body mass index (BMI) exerted strong effects on interleukin-6 and C-reactive protein levels in those with MDD. CONCLUSIONS:Childhood maltreatment did not exert effects on inflammatory marker levels in either the participants with MDD or the control group in our study. Our results instead highlight the more pertinent influence of BMI.Declaration of interestD.A.C. and H.W. work for Eli Lilly Inc. R.N. has received speaker fees from Sunovion, Jansen and Lundbeck. G.B. has received consultancy fees and funding from Eli Lilly. R.H.M.-W. has received consultancy fees or has a financial relationship with AstraZeneca, Bristol-Myers Squibb, Cyberonics, Eli Lilly, Ferrer, Janssen-Cilag, Lundbeck, MyTomorrows, Otsuka, Pfizer, Pulse, Roche, Servier, SPIMACO and Sunovian. I.M.A. has received consultancy fees or has a financial relationship with Alkermes, Lundbeck, Lundbeck/Otsuka, and Servier. S.W. has sat on an advisory board for Sunovion, Allergan and has received speaker fees from Astra Zeneca. A.H.Y. has received honoraria for speaking from Astra Zeneca, Lundbeck, Eli Lilly, Sunovion; honoraria for consulting from Allergan, Livanova and Lundbeck, Sunovion, Janssen; and research grant support from Janssen. A.J.C. has received honoraria for speaking from Astra Zeneca, honoraria for consulting with Allergan, Livanova and Lundbeck and research grant support from Lundbeck
Skin-impedance in Fabry Disease: A prospective, controlled, non-randomized clinical study
<p>Abstract</p> <p>Background</p> <p>We previously demonstrated improved sweating after enzyme replacement therapy (ERT) in Fabry disease using the thermo-regularity sweat and quantitative sudomotor axon reflex tests. Skin-impedance, a measure skin-moisture (sweating), has been used in the clinical evaluation of burns and pressure ulcers using the portable dynamic dermal impedance monitor (DDIM) system.</p> <p>Methods</p> <p>We compared skin impedance measurements in hemizygous patients with Fabry disease (22 post 3-years of bi-weekly ERT and 5 ERT naive) and 22 healthy controls. Force compensated skin-moisture values were used for statistical analysis. Outcome measures included 1) moisture reading of the 100<sup>th </sup>repetitive reading, 2) rate of change, 3) average of 60–110<sup>th </sup>reading and 4) overall average of all readings.</p> <p>Results</p> <p>All outcome measures showed a significant difference in skin-moisture between Fabry patients and control subjects (p < 0.0001). There was no difference between Fabry patients on ERT and patients naïve to ERT. Increased skin-impedance values for the four skin-impedance outcome measures were found in a small number of dermatome test-sites two days post-enzyme infusions.</p> <p>Conclusion</p> <p>The instrument portability, ease of its use, a relatively short time required for the assessment, and the fact that DDIM system was able to detect the difference in skin-moisture renders the instrument a useful clinical tool.</p
Microtearding mode study in NSTX using machine learning enhanced reduced model
This article presents a survey of NSTX cases to study the microtearing mode
(MTM) stabilities using the newly developed global reduced model for Slab-Like
Microtearing modes (SLiM). A trained neutral network version of SLiM enables
rapid assessment (0.05s/mode) of MTM with accuracy providing an
opportunity for systemic equilibrium reconstructions based on the matching of
experimentally observed frequency bands and SLiM prediction across a wide range
of parameters. Such a method finds some success in the NSTX discharges, the
frequency observed in the experiment matches with what SLiM predicted. Based on
the experience with SLiM analysis, a workflow to estimate the potential MTM
frequency for a quick assessment based on experimental observation has been
established
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