13,189 research outputs found

    Estimating the power spectrum covariance matrix with fewer mock samples

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    The covariance matrices of power-spectrum (P(k)) measurements from galaxy surveys are difficult to compute theoretically. The current best practice is to estimate covariance matrices by computing a sample covariance of a large number of mock catalogues. The next generation of galaxy surveys will require thousands of large volume mocks to determine the covariance matrices to desired accuracy. The errors in the inverse covariance matrix are larger and scale with the number of P(k) bins, making the problem even more acute. We develop a method of estimating covariance matrices using a theoretically justified, few-parameter model, calibrated with mock catalogues. Using a set of 600 BOSS DR11 mock catalogues, we show that a seven parameter model is sufficient to fit the covariance matrix of BOSS DR11 P(k) measurements. The covariance computed with this method is better than the sample covariance at any number of mocks and only ~100 mocks are required for it to fully converge and the inverse covariance matrix converges at the same rate. This method should work equally well for the next generation of galaxy surveys, although a demand for higher accuracy may require adding extra parameters to the fitting function.Comment: 7 pages, 7 figure

    Chemical investigation of light induced DNA bipyrimidine damage and repair

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    In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage. The major photolesions formed are the cyclobutane pyrimidine dimers (CPD), pyrimidine–pyrimidone-(6-4)-photoproducts, Dewar valence isomers and, for dehydrated spore DNA, 5-(a-thyminyl)-5,6-dihydrothymine (SP). In order to be able to investigate how nature’s repair and tolerance mechanisms protect the integrity of genetic information, oligonucleotides containing sequence and site-specific UV lesions are essential. This tutorial review provides an overview of synthetic procedures by which these oligonucleotides can be generated, either through phosphoramidite chemistry or direct irradiation of DNA. Moreover, a brief summary on their usage in analysing repair and tolerance processes as well as their biological effects is provided

    Explicit comprehension instruction : a review of research and a new conceptualization of instruction

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    Includes bibliographical references (p. 13-16)The work upon which this publication was based was supported in part by the Office of Educational Research and Improvement under cooperative agreement no. OEG 0087-C100
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