Epidemiologic Questions from Anthrax Outbreak, Hunter Valley, Australia

Anthrax was introduced into Australia in 1847 near Sydney, New South Wales, and spread along stock routes throughout New South Wales and southern Queensland. Anthrax was considered endemic to the Hunter Valley, New South Wales, during the 1890s. The last recorded anthrax-related stock losses there occurred on 3 properties in the Upper Hunter Valley in 1939. During the past 4 decades, anthrax has become uncommon in Australia. However, our experience is a timely reminder that veterinary public health authorities should be on high alert for possible anthrax when unexpected livestock deaths follow flooding in areas where anthrax has historically occurred

Advances in single carrier block modulation with frequency domain processing

International audienceThis special issue focuses on single carrier block modulation (SC-BM) with frequency domain processing. This class of modulation and multiple access schemes complements the orthogonal frequency division multiple access (OFDMA) and its variations. For example, LTE (the long term evolution of the 3GPP standard), and LTE-Advanced, employ OFDMA in the downlink (base stations to mobiles) and SC-FDMA, a version of SC-BM in the uplink (mobiles to base stations). The main reason for adapting the technology of SC-FDMA for uplink LTE is the fact that OFDMA has high "peak-to-average power ratio" (PAPR), which is a disadvantage for mobile devices that are limited by power availability. Besides its advantage of low PAPR, SC-BM technology has a similar performance/complexity to that of OFDMA, and simple frequency domain equalization methods for combating dispersive channels. There were 17 papers submitted to this special issue. All had merits, but the review process reduced the number of accepted papers to 9. The accepted papers cover a number of novel and advanced aspects of single carrier block modulation with frequency domain processing: near-optimal nonlinear and iterative equalization techniques; applications to CDMA, MIMO and ARQ; channel estimation; and application to free-space optical transmission. Following is a summary of the papers. In the paper "Iterative Successive Interference Cancellation for Quasi-Synchronous Block Spread CDMA Based on the Orders of the Times of Arrival", Wang, Bocus, and Coon [1] describe an interference cancellation scheme based on the times of arrival of the signals from different users, and they show that for practical channels this ordering criterion is equivalent to ordering with respect to decreasing average SINR. In "Complexity Reduced MLD Based on QR Decomposition in OFDM MIMO Multiplexing with Frequency Domain Spreading and Code Multiplexing", Nagatomi, Kawai, and Higuchi [2] propose a reduced-complexity maximum likelihood signal detection method for MIMO-OFDM systems with frequency-domain spreading and code multiplexing. They show how to exploit signal orthogonalization based on QR decomposition of the product of the channel and spreading code matrices in the frequency domain to obtain significant complexity reductions. In "Frequency-domain Block Signal detection with QRM-MLD for Training Sequence-aided Single-carrier Transmission", Yamamoto, Takeda and Adachi [3] propose replacement of the cyclic prefix with a known training sequence. The object is to improve BER performance of an equalization scheme which uses QR decomposition with M-algorithm detection, while keeping the number of surviving paths low for reduced complexity. The scheme is especially effective for 16QAM and 64QAM modulation. The paper "Joint Iterative Tx/Rx MMSE-FDE and ISI Cancellation for Single-carrier Hybrid ARQ with Chase Combining" by Takeda and Adachi [4] applies transmitter and receiver equalization and iterative intersymbol interference cancellation to a system with hybrid ARQ transmission, Chase combining and antenna diversity. The equalizer parameters at both transmitter and receiver are optimized for each retransmission. The paper "Novel Techniques of Single Carrier Frequency Domain Equalization for Optical Wireless Communications" by Acolaste, Bar-Ness, and Wilson [5] investigates the application of single-carrier frequency-domain equalization to diffuse optical wireless communications and demonstrates its advantages over OFDM in terms of reduced PAPR and improved error rate in the presence of LED nonlinearity. In the paper "Semi-Blind Channel Estimation for IFDMA in Case of Channels with Large Delay Spreads", Sohl and Klein [6] propose a subspace-based channel estimation algorithm which can cope with large delay spreads. In previous work on IFDMA, the number of channel taps that can be estimated was limited to the number of subcarriers per user. The subspace analysis in this paper relaxes this constraint and increases the number of taps that can be estimated. The paper "Channel Frequency response Estimation for MIMO with Systems with Frequency-Domain Equalization " by Yang, Shi, Chew, and Tjhung [7] suggests a training-based channel frequency response (CFR) estimation scheme which is hardware efficient when integrated with and SC-FDE and space time coding (STC) in MIMO Systems. An MSE analysis of this CFR estimation scheme is provided, which considered linear estimators based on both LS and minimum MSE criteria. Also with a given constraint which effectively limits the transmit power of the training signals, the paper investigates the optimal design of training signals under different a priori knowledge of the channel statistics. For the special case of 2 transmit antennas, it was demonstrated that CFR estimation could be implemented in adaptive manner. The paper by Dang, Ruder, Schober and Gerstacker [8], "MMSE Beamforming for SC-FDMA Transmission over MIMO ISI Channels", derives minimum mean squared error beamforming strategies for multi-antenna reception, as well as further modifications to reduce the transmitted peak to average power ratios. The paper by Nishino, Tanahashi, and Ochiai [9], "A Bit Labeling Design for Trellis-Shaped Single-Carrier PSK with PAPR Reduction", investigates application of trellis shaping to reduce the PAPR of band-limited single-carrier PSK signals. The authors demonstrate that the uncoded bit error rate and PAPR reduction capability of trellis shaping is highly dependent on bit labeling. They propose a bit labeling scheme for high-order PSK constellation that can efficiently reduce PAPR while achieving BER performance comparable to that of Gray labeling

Pedagogical Agents for Fostering Question-Asking Skills in Children

Question asking is an important tool for constructing academic knowledge, and a self-reinforcing driver of curiosity. However, research has found that question asking is infrequent in the classroom and children's questions are often superficial, lacking deep reasoning. In this work, we developed a pedagogical agent that encourages children to ask divergent-thinking questions, a more complex form of questions that is associated with curiosity. We conducted a study with 95 fifth grade students, who interacted with an agent that encourages either convergent-thinking or divergent-thinking questions. Results showed that both interventions increased the number of divergent-thinking questions and the fluency of question asking, while they did not significantly alter children's perception of curiosity despite their high intrinsic motivation scores. In addition, children's curiosity trait has a mediating effect on question asking under the divergent-thinking agent, suggesting that question-asking interventions must be personalized to each student based on their tendency to be curious.Comment: Accepted at CHI 202

Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography

OBJECTIVE: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization. This analysis describes data obtained from chronic ambulatory ECoG in patients with suspected bilateral MTL epilepsy in order to assess the time required to determine the seizure lateralization and whether this information could influence treatment decisions. METHODS: Ambulatory ECoG was reviewed in patients with suspected bilateral MTL epilepsy who were among a larger cohort with intractable epilepsy participating in a randomized controlled trial of responsive neurostimulation. Subjects were implanted with bilateral MTL leads and a cranially implanted neurostimulator programmed to detect abnormal interictal and ictal ECoG activity. ECoG data stored by the neurostimulator were reviewed to determine the lateralization of electrographic seizures and the interval of time until independent bilateral MTL electrographic seizures were recorded. RESULTS: Eighty-two subjects were implanted with bilateral MTL leads and followed for 4.7 years on average (median 4.9 years). Independent bilateral MTL electrographic seizures were recorded in 84%. The average time to record bilateral electrographic seizures in the ambulatory setting was 41.6 days (median 13 days, range 0-376 days). Sixteen percent had only unilateral electrographic seizures after an average of 4.6 years of recording. SIGNIFICANCE: About one third of the subjects implanted with bilateral MTL electrodes required >1 month of chronic ambulatory ECoG before the first contralateral MTL electrographic seizure was recorded. Some patients with suspected bilateral MTL seizures had only unilateral electrographic seizures. Chronic ambulatory ECoG in patients with suspected bilateral MTL seizures provides data in a naturalistic setting, may complement data from inpatient video-EEG monitoring, and can contribute to treatment decisions

Asteroseismology with the Roman Galactic Bulge Time-Domain Survey

Asteroseismology has transformed stellar astrophysics. Red giant asteroseismology is a prime example, with oscillation periods and amplitudes that are readily detectable with time-domain space-based telescopes. These oscillations can be used to infer masses, ages and radii for large numbers of stars, providing unique constraints on stellar populations in our galaxy. The cadence, duration, and spatial resolution of the Roman galactic bulge time-domain survey (GBTDS) are well-suited for asteroseismology and will probe an important population not studied by prior missions. We identify photometric precision as a key requirement for realizing the potential of asteroseismology with Roman. A precision of 1 mmag per 15-min cadence or better for saturated stars will enable detections of the populous red clump star population in the Galactic bulge. If the survey efficiency is better than expected, we argue for repeat observations of the same fields to improve photometric precision, or covering additional fields to expand the stellar population reach if the photometric precision for saturated stars is better than 1 mmag. Asteroseismology is relatively insensitive to the timing of the observations during the mission, and the prime red clump targets can be observed in a single 70 day campaign in any given field. Complementary stellar characterization, particularly astrometry tied to the Gaia system, will also dramatically expand the diagnostic power of asteroseismology. We also highlight synergies to Roman GBTDS exoplanet science using transits and microlensing.Comment: Roman Core Community Survey White Paper, 3 pages, 4 figure