8 research outputs found
Building a basic membrane computer
In this work, we present the building of two well-known membrane com-
puters (squares generator and divisor test). Although they are very basic machines they
present problems common to every P system (competition, parallel execution of rules,
membrane dissolution, etc.) that have to be solved in order to get real emulations for
them. The presented designs mimic the systems operation in a realistic way, by achieving
both maximum parallelism and non-determinism, and demonstrating for the rst time
that a membrane computer can actually be built in silico. Our architectures fully emu-
late the membranes behaviour yielding to a performance of one transition per clock cycle,
supposing a real physical realization of the mentioned machines
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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
Implementation of a configuration server for a hardware SNTP synchronization platform based on FPGA
This paper presents the implementation of a configuration
server for a SNTP synchronization platform which implements
accurate synchronization solutions for Remote Terminal
Units commonly used in industrial control processes.
The configuration server provides settings to others platform
devices using the BOOTP protocol and an interface
that allow to administer the system. This environment requires
a compact (specific dimensions) and low power and
low cost device. Thus, a general purpose device (e.g. a PC)
is discarded and an embedded one with these features has
been developed. However, in addition to these requirements
it offers a flexibility similar to the PC. Thereby it is able to
update and carry out tasks beyond synchronization platform
easily.Ministerio de Educación y Cultura TEC2007-61802/MICMinisterio de Industria, Turismo y Comercio TSI-020100-2008-25
Evaluation of Fibrin-Agarose Tissue-Like Hydrogels Biocompatibility for Tissue Engineering Applications
Generation of biocompatible and biomimetic tissue-like biomaterials is crucial to ensure
the success of engineered substitutes in tissue repair. Natural biomaterials able to
mimic the structure and composition of native extracellular matrices typically show
better results than synthetic biomaterials. The aim of this study was to perform an
in vivo time-course biocompatibility analysis of fibrin-agarose tissue-like hydrogels
at the histological, imagenological, hematological, and biochemical levels. Tissue-like
hydrogels were produced by a controlled biofabrication process allowing the generation
of biomechanically and structurally stable hydrogels. The hydrogels were implanted
subcutaneously in 25 male Wistar rats and evaluated after 1, 5, 9, and 12 weeks
of in vivo follow-up. At each period of time, animals were analyzed using magnetic
resonance imaging (MRI), hematological analyses, and histology of the local area in
which the biomaterials were implanted, along with major vital organs (liver, kidney,
spleen, and regional lymph nodes). MRI results showed no local or distal alterations
during the whole study period. Hematology and biochemistry showed some fluctuation
in blood cells values and in some biochemical markers over the time. However, these
parameters were progressively normalized in the framework of the homeostasis process.
Histological, histochemical, and ultrastructural analyses showed that implantation of
fibrin-agarose scaffolds was followed by a progressive process of cell invasion, synthesis
of components of the extracellular matrix (mainly, collagen) and neovascularization.
Implanted biomaterials were successfully biodegraded and biointegrated at 12 weeks
without any associated histopathological alteration in the implanted zone or distal vital
organs. In summary, our in vivo study suggests that fibrin-agarose tissue-like hydrogels
could have potential clinical usefulness in engineering applications in terms of biosafety
and biocompatibility.Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+i) from the Spanish Ministerio de Ciencia, Innovacion y Universidades (Instituto de Salud Carlos III) (ERDF-FEDER, European Union)
FIS PI17/0391
PI17/0393
PI18/332ISCIII thorough AES 2017
AC17/00013EuroNanoMed framework
AC17/00013Hispanagar, SA, Burgos, Spain, through CDTI, Ministry of Economy and Competitiveness, Spain
IDI-20180052Junta de Andalucia
CS PI-0257-2017
PE-0395-2019Ministerio de Economia, Industria y Competitividad, MINECO
FIS2017-85954-RAgencia Estatal de Investigacion, AEI, Spain
FIS2017-85954-REuropean Union (EU)
FIS2017-85954-RNational Cordoba University, Argentina
Secyt 266
HCS 659/2018Programa Operativo Pluriregional de Crecimiento Inteligente (CRIN)
IDI-20180052ERDF-FEDER funds, EU
IDI-2018005
HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) mice. Recently, we have shown that before cerebellar degeneration takes place, the tbl mouse suffers from a reduction in the number of vesicles available for release at the neuromuscular junction (NMJ). The aim of the present work was to study to which extent the alteration in HERC1 may affect other cells in the nervous system and how this may influence the motor dysfunction observed in these mice. The functional analysis showed a consistent delay in the propagation of the action potential in mutant mice in comparison with control littermates. Morphological analyses of glial cells in motor axons revealed signs of compact myelin damage as tomacula and local hypermyelination foci. Moreover, we observed an alteration in non-myelinated terminal Schwann cells at the level of the NMJ. Additionally, we found a significant increment of phosphorylated Akt-2 in the sciatic nerve. Based on these findings, we propose a molecular model that could explain how mutated HERC1 in tbl mice affects the myelination process in the peripheral nervous system. Finally, since the myelin abnormalities found in tbl mice are histological hallmarks of neuropathic periphery diseases, tbl mutant mice could be considered as a new mouse model for this type of diseases
Tratamientos Psicológicos Empíricamente Apoyados Para la Infancia y Adolescencia: : Estado de la Cuestión
Background: The empirical
evidence accumulated on the effi cacy, effectiveness, and effi ciency of
psychotherapeutic treatments in children and adolescents calls for an
update. The main goal of this paper objective was to carry out a selective
review of empirically supported psychological treatments for a variety
of common psychological disorders and problems in childhood and
adolescence. Method: A review was carried out of the psychological
treatments for different psychological disorders and problems in socialemotional or behavioral adjustment in the child-adolescent population
according to the Spanish National Health System (Clinical Practice
Guidelines) levels of evidence and degrees of recommendation. Results:
The fi ndings suggest that psychological treatments have empirical
support for addressing a wide range of psychological problems in these
developmental stages. The degree of empirical support ranges from low
to high depending on the phenomenon analyzed. The review suggests
unequal progress in the different fi elds of intervention. Conclusions:
From this update, psychologists will be able to make informed decisions
when implementing those empirically supported treatments to address the
problems that occur in childhood and adolescence.Antecedentes: la evidencia empírica acumulada en los últimos años sobre
la efi cacia, efectividad y efi ciencia de los tratamientos psicológicos en la
infancia y adolescencia reclama una actualización. El principal objetivo
de este artículo es el de llevar a cabo una revisión de los tratamientos
psicológicos empíricamente apoyados para una diversidad de problemas
psicológicos habituales en la infancia y la adolescencia. Método:
se revisan los tratamientos psicológicos para diferentes trastornos
psicológicos y problemas en el ajuste socioemocional o conductual en
población infanto-juvenil en función de los niveles de evidencia y grados
de recomendación del Sistema Nacional de Salud de España (Guías de
Práctica Clínica). Resultados: los hallazgos sugieren que los tratamientos
psicológicos específi camente dirigidos a niños, niñas y adolescentes
disponen de apoyo empírico para el abordaje de un amplio elenco de
problemas psicológicos. Este grado de apoyo empírico oscila de bajo a
alto en función del problema analizado. La revisión muestra un avance
desigual en los diferentes campos de intervención. Conclusiones: a partir
de esta actualización, los profesionales de la psicología podrán tomar
decisiones informadas a la hora de implementar aquellas intervenciones
psicológicas con apoyo empírico para el abordaje de los problemas en la
infancia y la adolescenci
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