307 research outputs found

    Use of the Montreal Cognitive Assessment as an Early Indicator of Tumor Progression in Patient with Stage III and IV Gliomas

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    Patients diagnosed with high grade glioma have a short life expectancy due to rapid progression of disease following and/or during treatment. Magnetic resonance imaging (MRI) is the primary method of surveying tumor progression, but is costly, lengthy in duration and often uncomfortable for the patient. An alternative to MRI that is cost efficient and patient friendly is of great interest to the medical community. If this alternative could also provide advanced notification of disease progression, then this patient population would have the opportunity for earlier treatment and the potential for greater efficacy. To pursue this concept, we assessed whether the Montreal Cognitive Assessment (MoCA) could be that MRI alternative, potentially providing an early identifier of disease progression for the high grade glioma population. We retrospectively assessed a variety of medical and surgical data points, in conjunction with the MoCA scores for individuals with a high grade glioma diagnosis who received surgery and/or biopsy with radiation treatment and had at least one instance of disease progression. Of the 128 subjects intended to fulfill our sample size requirement, only 5 subjects qualified for enrollment. Our statistical tests were greatly impacted by this unfortunate circumstance and because of this we were not able to support the MoCA as hypothesized because the results did not reach the level of statistical significance. We have identified many interesting trends, but without an appropriate sample size these cannot be validated. We hope the study concept and design will provide the basis for future research that can build upon our hypothesis and provide a definite answer

    Spectral pitch distance and microtonal melodies

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    We present an experiment designed to test the effectiveness of spectral pitch distance at modeling the degree of “affinity” or “fit” of pairs of successively played tones or chords (spectral pitch distance is the cosine distance between salience-weighted, Gaussian-smoothed, pitch domain embeddings of spectral pitches—typically the first eight to ten partials of a tone). The results of a previously conducted experiment, which collected ratings of the perceived similarity and fit of root-position major and minor triads, suggest the model works well for pairs of triads in standard 12-tone equal temperament tunings. The new experiment has been designed to test the effectiveness of spectral pitch distance at modeling the affinity of tones in microtonal melodies where the partials of the tones can be variably tempered between being perfectly harmonic and perfectly matched to the underlying microtonal tuning. The use of microtonal tunings helps to disambiguate innate perceptual (psychoacoustical) responses from learned (cultural) responses. Participants are presented with a software synthesizer containing two unlabeled controls: one adjusts the precise tuning of the tones; the other adjusts the extent to which the spectrum is tempered to match the tuning (as set by the first control). A selection of microtonal melodies are played in different tunings, and the participants adjust one, or both, controls until they find a “sweet spot” at which the music sounds most “in-tune” and the notes best “fit” together. The results of these experiments will be presented and discussed

    Materials in Centrifugal Compressor and Steam Turbines: Selection, Processing, and Repair

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    Short CoursesMaterials selection is significant with respect to performance, reliability, and longevity of turbomachinery, particularly given the increasing severity of the process environments. The trends are that the selection is becoming a cooperative effort between the OEM’s and the customers and it is vital that all parties understand the implications of the materials selection and necessary manufacturing processes. This course reviews the material selection for major components for centrifugal compressors and steam turbines coving topics such as materials of construction, heat treatments, properties, fabrication and manufacturing methods, inspection methods, and compliance with industry specifications such as API and NACE along with other special requirements. Going beyond new equipment, the course will touch on the identification of damage mechanisms through root cause analysis and then delve into the procedures and documentation required to restore the components to operating condition. The course will end with a discussion of various coatings and surface treatments that can also be used to enhance the performance and/or longevity of the equipment

    A spectral pitch class model of the probe tone data and scalic tonality

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    In this paper, we introduce a small family of novel bottom-up (sensory) models of the Krumhansl and Kessler (1982) probe tone data. The models are based on the spectral pitch class similarities between all twelve pitch classes and the tonic degree and tonic triad. Cross-validation tests of a wide selection of models show ours to have amongst the highest fits to the data. We then extend one of our models to predict the tonics of a variety of different scales such as the harmonic minor, melodic minor, and harmonic major. The model produces sensible predictions for these scales. Furthermore, we also predict the tonics of a small selection of microtonal scales—scales that do not form part of any musical culture. These latter predictions may be tested when suitable empirical data have been collected

    METS2 Short Course 8

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    Short Cours

    Hex Player—a virtual musical controller

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    In this paper, we describe a playable musical interface for tablets and multi-touch tables. The interface is a generalized keyboard, inspired by the Thummer, and consists of an array of virtual buttons. On a generalized keyboard, any given interval always has the same shape (and therefore fingering); furthermore, the fingering is consistent over a broad range of tunings. Compared to a physical generalized keyboard, a virtual version has some advantages—notably, that the spatial location of the buttons can be transformed by shears and rotations, and their colouring can be changed to reflect their musical function in different scales. We exploit these flexibilities to facilitate the playing not just of conventional Western scales but also a wide variety of microtonal generalized diatonic scales known as moment of symmetry, or well-formed, scales. A user can choose such a scale, and the buttons are automatically arranged so their spatial height corresponds to their pitch, and buttons an octave apart are always vertically above each other. Furthermore, the most numerous scale steps run along rows, while buttons within the scale are light-coloured, and those outside are dark or removed. These features can aid beginners; for example, the chosen scale might be the diatonic, in which case the piano’s familiar white and black colouring of the seven diatonic and five chromatic notes is used, but only one scale fingering need ever be learned (unlike a piano where every key needs a different fingering). Alternatively, it can assist advanced composers and musicians seeking to explore the universe of unfamiliar microtonal scales
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