631 research outputs found
Sensor data to measure Hawthorne effects in cookstove evaluation.
This data in brief article includes estimated time cooking based on temperature sensor data taken every 30 min from three stone fires and introduced fuel-efficient Envirofit stoves in approximately 168 households in rural Uganda. These households were part of an impact evaluation study spanning about six months to understand the effects of fuel-efficient cookstoves on fuel use and pollution. Daily particulate matter (pollution) and fuelwood use data are also included. This data in brief file only includes the weeks prior to, during, and after an in-person measurement team visited each home. The data is used to analyze whether households change cooking patterns when in-person measurement teams are present versus when only the temperature sensor is in the home
Further evidence for early lunar magnetism from troctolite 76535
The earliest history of the lunar dynamo is largely unknown and has important implications for the thermal state of the Moon and the physics of dynamo generation. The lunar sample with the oldest known paleomagnetic record is the 4.25 billion year old (Ga) troctolite 76535. Previous studies of unoriented subsamples of 76535 found evidence for a dynamo field with a paleointensity of several tens of microteslas. However, the lack of mutual subsample orientation prevented a demonstration that the magnetization was unidirectional, a key property of thermoremanent magnetization. Here we report further alternating field demagnetization on three mutually oriented subsamples of 76535, as well as new pressure remanent magnetization experiments to help rule out shock magnetization. We also describe new 40Ar/39Ar thermochronometry and cosmogenic neon measurements that better constrain the rock's thermal history. Although the rock is unbrecciated, unshocked, and slowly cooled, its demagnetization behavior is not ideal due to spurious remanence acquisition. Despite this limitation, all three subsamples record a high coercivity magnetization oriented in nearly the same direction, implying that they were magnetized by a unidirectional field on the Moon. We find no evidence for shock remanence, and our thermochronometry calculations show no significant reheating events since 4249 ± 12 million years ago (Ma). We infer a field paleointensity of approximately 20–40 μT, supporting the previous conclusion that a lunar dynamo existed at 4.25 Ga. The timing of this field supports an early dynamo powered by thermal or thermochemical core convection and/or a mechanical dynamo but marginally excludes a dynamo delayed by thermal blanketing from radiogenic element-rich magma ocean cumulates
Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization
Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular response to stress and inflammation, highlighting the potential for cross-talk between these two signaling pathways. We present results from an unbiased in vivo chemical screen in zebrafish that identifies GCs as activators of hypoxia-inducible factors (HIFs) in the liver. GCs activated consensus hypoxia response element (HRE) reporters in a glucocorticoid receptor (GR)-dependent manner. Importantly, GCs activated HIF transcriptional responses in a zebrafish mutant line harboring a point mutation in the GR DNA-binding domain, suggesting a nontranscriptional route for GR to activate HIF signaling. We noted that GCs increase the transcription of several key regulators of glucose metabolism that contain HREs, suggesting a role for GC/HIF cross-talk in regulating glucose homeostasis. Importantly, we show that GCs stabilize HIF protein in intact human liver tissue and isolated hepatocytes. We find that GCs limit the expression of Von Hippel Lindau protein (pVHL), a negative regulator of HIF, and that treatment with the c-src inhibitor PP2 rescued this effect, suggesting a role for GCs in promoting c-src–mediated proteosomal degradation of pVHL. Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL
From the Classroom to the Tip of the Spear – Designing a System to Track USMA’s Intellectual Capital
As the world becomes increasingly interconnected and unstable, the US Army’s mission becomes more complex. This reality, when coupled with a smaller force, is increasing the Army’s reliance on foreign partners and its need for non-traditional skills. Given these challenges, deployed units often offset capability gaps using “reachback,” the act of contacting external organizations for critical expertise. Based on recent support to the 1st Infantry Division in Iraq, the United States Military Academy (USMA) possesses considerable reachback potential; however, to fulfill such requests, USMA must first understand its capability and capacity. With this in mind, our research shows that although USMA’s faculty is quite willing to help deployed units, no formalized process exists to catalogue and leverage its collective intellectual capital. As such, we identify the requirement for an intuitive system to fill this void, and we develop and analyze several alternative
Water security, risk, and economic growth: Insights from a dynamical systems model
Investments in the physical infrastructure, human capital, and institutions needed for water resources management have been noteworthy in the development of most civilisations. These investments affect the economy in two distinct ways: (i) by improving the factor productivity of water in multiple economic sectors, especially those that are water intensive such as agriculture and energy; and (ii) by reducing acute and chronic harmful effects of water-related hazards like floods, droughts, and water-related diseases. The need for capital investment to mitigate risks and promote economic growth is widely acknowledged, but prior conceptual work on the relationship between water-related investments and economic growth has focused on the productive and harmful roles of water in the economy independently. Here the two influences are combined using a simple, dynamical systems model of water-related investment, risk, and growth. In cases where initial water security is low, initial investment in water-related assets enables growth. Without such investment, losses due to water-related hazards exert a drag on economic growth and may create a poverty trap. The presence and location of the poverty trap is context-specific and depends on the exposure of productive water-related assets to water-related risk. Exogenous changes in water-related risk can potentially push an economy away from a growth path towards a poverty trap. Our investigation shows that an inverted-U-shaped investment relation between the level of investment in water security and the current level of water security leads to faster rates of growth than the alternatives that we consider here, and that this relation is responsible for the 'S'-curve that is posited in the literature. These results illustrate the importance of accounting for environmental and health risks in economic models and offer insights for the design of robust policies for investment in water-related productive assets to manage risk, in the face of environmental change
Towards an Airframe Noise Prediction Methodology: Survey of Current Approaches
In this paper, we present a critical survey of the current airframe noise (AFN) prediction methodologies. Four methodologies are recognized. These are the fully analytic method, CFD combined with the acoustic analogy, the semi-empirical method and fully numerical method. It is argued that for the immediate need of the aircraft industry, the semi-empirical method based on recent high quality acoustic database is the best available method. The method based on CFD and the Ffowcs William- Hawkings (FW-H) equation with penetrable data surface (FW-Hpds ) has advanced considerably and much experience has been gained in its use. However, more research is needed in the near future particularly in the area of turbulence simulation. The fully numerical method will take longer to reach maturity. Based on the current trends, it is predicted that this method will eventually develop into the method of choice. Both the turbulence simulation and propagation methods need to develop more for this method to become useful. Nonetheless, the authors propose that the method based on a combination of numerical and analytical techniques, e.g., CFD combined with FW-H equation, should also be worked on. In this effort, the current symbolic algebra software will allow more analytical approaches to be incorporated into AFN prediction methods
Genomic Prediction and QTL Mapping Using Bayesian Methods
Several genomic selection methods were applied to a data set that was simulated for the 2010 QTLMAS workshop to predict the genomic breeding values (GEBV) of the offspring generation and to map the QTL. The GEBV had an accuracy of 0.894 with very small bias. QTL were detected based on the variance of 10 SNP windows. Using a threshold chosen for a 10% chromosome-wise type-I error rate, most of the large QTL were successfully detected with few false positives. Results for both prediction of breeding values and detection of QTL were among the best among all analyses of this data set by groups across the globe. Genomic selection method BayesCπ was identified to be appropriate for the 2010 QTLMAS dataset and also applicable to real cases with similar settings
Breaking Barriers: Strategies for Fostering Inclusivity in The Workplace
This paper focuses on promoting inclusivity in the workplace, particularly addressing equality and inequality issues. Its objective is to provide practical tips and advice to managers on fostering an inclusive workplace culture, recognizing the significance of inclusion for employee well-being and organizational success. The researchers define and discuss various forms of workplace inequality, examine root causes, and then present a comprehensive range of tactics managers can use to encourage diversity. The paper explores creating an inclusive work culture, implementing diversity and inclusion policies, ensuring fair hiring processes, addressing bias and discrimination, promoting diversity training, and providing equal chances for career growth. Furthermore, the paper delves into the obstacles that hinder the attainment of inclusivity, including resistance to change, unintentional prejudices, ignorance, and structural barriers. It supplements these discussions with best practices, illustrating successful examples of organizations that have effectively promoted inclusivity in the workplace. The methodology to be employed involves a qualitative research approach. The paper underscores the importance of promoting inclusivity and urges managers to address equality and inequality issues actively. By implementing these strategies, managers can cultivate a culture of equality where all employees can thrive and contribute to the company's success.This article is published as Garrick, A., Johnson, W. D., & Arendt, S. W. (2024). Breaking Barriers: Strategies for Fostering Inclusivity in The Workplace. International Journal of Academic Research in Business and Social Sciences, 14(2), 128–152. http://dx.doi.org/10.6007/IJARBSS/v14-i2/20799. Copyright: © 2024 The Author(s
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